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Environmental Factors, Genes, and the Development of Human Cancers pp 223–252Cite as

Gene–Environment Interaction and Susceptibility to Pediatric Brain Tumors

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Abstract

Many pediatric brain tumors (pBTs) may result from the interplay of environmental factors with biological mechanisms at critical developmental periods in a child’s life. While several genetic disorders have been linked to development of pBTs, many pBTs may result from low-penetrant gene alterations in common pathways. Importantly, alterations and pathways that may be important to etiology in certain tumor types may not play a role in other pBT types. It is probable that heterogeneity in alterations, and possibly even pathways, exists within tumor groups as well. Identification of which pathways are most significant in the etiology of each pBT type will be critical in developing therapies for these tumors. While therapies for single gene mutations have been successful in the past for certain cancers, it is possible that therapies based on pathway inhibition will prove to be more successful in the treatment of tumors that have several mutations throughout a pathway such as pBTs. This chapter describes the current state of the research on environmental, genetic, and epigenetic factors possibly involved in the development of pBTs. It covers epidemiological research on environmental factors that have been investigated in relation to pBTs, the involvement of neural stem cells, progenitor cells, and developmental pathways in the etiology of pBTs, the genetic and epigenetic alterations that have been identified in common pBTs, and how these factors may interact with mitochondrial-nuclear signaling to increase individual susceptibility to pBTs.

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Authors and Affiliations

  1. Department of Environmental and Occupational Health, Robert Stempel College of Public Health, Florida International University, Miami, FL, 33199, USA

    Brian Kunkle

  2. Department of Neurological Surgery, School of Medicine, Miami Children’s Hospital, University of Miami, Miami, FL, 33155, USA

    David Sandberg & Prasanna Jayakar

  3. Department of Environmental and Occupational Health, FIU Stempel School of Public Health, Florida International University, Miami, FL, 33199, USA

    Quentin Felty

  4. Department of Environmental and Occupational Health, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, 33199-0001, USA

    Deodutta Roy

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  1. Brian Kunkle
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  2. David Sandberg
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  3. Prasanna Jayakar
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  4. Quentin Felty
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  5. Deodutta Roy
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Correspondence to Deodutta Roy .

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  1. Robert Stempel School of Public Health, Dept. Environmental & Occupational Healt, Florida International University, SW. 8th Street 11200, Miami, 33199-0001, Florida, USA

    Deodutta Roy

  2. Robert Stempel College of Public Health, Department of Environmental and Occupati, Florida International University, Miami, 33199-0001, Florida, USA

    M. Tevfik Dorak

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Kunkle, B., Sandberg, D., Jayakar, P., Felty, Q., Roy, D. (2010). Gene–Environment Interaction and Susceptibility to Pediatric Brain Tumors. In: Roy, D., Dorak, M. (eds) Environmental Factors, Genes, and the Development of Human Cancers. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6752-7_9

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