Biomathematics and Biostatistics



The division of biomathematics and biostatistics was established in 2004 with A. Niemierko as the Head. The intent was to provide an organized program in biomathematics in clinical radiation oncology. The principal function is to collaborate with clinicians in the design of clinical studies, analysis of the resultant data, and development of new model systems and concepts for clinically related biomathematics and statistics. Further, the faculty is to contribute biomath and biostatistics lectures in the educational courses for residents and pre- and post-doctoral fellows.


Tumor Control Probability Isotonic Regression Hewlett Packard Equivalent Uniform Dose Single Radiation Dose 
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  1. 1.
    Ancukiewicz M, Finkelstein DM, Schoenfeld DA. Modeling the relationship between continuous covariates and clinical events using isotonic regression. Stat Med. 2003;57:701–8.Google Scholar
  2. 2.
    Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83–95.CrossRefPubMedGoogle Scholar
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    Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351:327–36.CrossRefPubMedGoogle Scholar
  4. 4.
    Choi NC, Fischman AJ, Niemierko A, et al. Dose-response relationship between probability of pathologic tumor control and glucose metabolic rate measured with FDG PET after preoperative chemoradiotherapy in locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2002;54(4):1024–35.CrossRefPubMedGoogle Scholar
  5. 5.
    Goldberg S, Niemierko A, Turchin A. Analysis of data errors in clinical research databases. AMIA Annu Symp Proc. 2008;32:242–6.Google Scholar
  6. 6.
    Kepka L, Suit HD, Goldberg SI, et al. Results of radiation therapy performed after unplanned surgery(without re-excision) for soft tissue sarcomas. J Surg Oncol. 2005;92(1):39–45.CrossRefPubMedGoogle Scholar
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    Lee CG, Heijn M, di Tomaso E, et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000;60:5565–70.PubMedGoogle Scholar
  8. 8.
    Loeffler JS, Niemierko A, Chapman PH. Second tumors after radiosurgery: tip of the iceberg or a bump in the road? Neurosurgery. 2003;52(6):1436–40.CrossRefPubMedGoogle Scholar
  9. 9.
    Niemierko A. Reporting and analyzing dose distributions: a concept of Equivalent Uniform Dose (EUD). Med Phys. 1997;24(1):17–26.CrossRefGoogle Scholar
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    Suit H, Goldberg S, Niemierko A, et al. Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007;167(1):12–42.CrossRefPubMedGoogle Scholar
  11. 11.
    Terahara A, Niemierko A, Goitein M, et al. Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys. 1999;45(2):351–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Willett CG, Del Castillo CF, Shih HA, et al. Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer. Ann Surg. 2005;241(2):295–9.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Radiation OncologyMassachusetts General HospitalBostonUSA

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