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Ceramide-1-Phosphate in Phagocytosis and Calcium Homeostasis

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Sphingolipids as Signaling and Regulatory Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 688))

Abstract

Sphingolipids are well established sources of important signaling molecules. For example, ceramide (Cer) has been described as a potent inhibitor of cell growth and inducer of apoptosis. In contrast, ceramide-1-phosphate (C1P) has been reported to have mitogenic properties and to inhibit apoptosis. Our understanding of the distinct biological roles of C1P in the regulation of DNA synthesis, inflammation, membrane fusion and intracellular Ca2+ increase has rapidly expanded. C1P is a bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). This chapter specifically focuses on the role of C1P in phagocytosis and Ca2+ homeostasis. Studies of the metabolism of C1P during phagocytosis, may lead to a better understanding of its role in signaling. Potentially, the inhibition of CERK and C1P formation may be a therapeutic target for inflammation.

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Author information

Authors and Affiliations

  1. Department of Pediatrics Division of Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Vania Hinkovska-Galcheva

  2. Department of Internal Medicine Nephrology Division, University of Michigan Medical School, Ann Arbor, Michigan, USA

    James A. Shayman

Authors
  1. Vania Hinkovska-Galcheva
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  2. James A. Shayman
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Corresponding author

Correspondence to Vania Hinkovska-Galcheva .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, USA

    Charles Chalfant PhD

  2. Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA

    Maurizio Del Poeta MD

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Hinkovska-Galcheva, V., Shayman, J.A. (2010). Ceramide-1-Phosphate in Phagocytosis and Calcium Homeostasis. In: Chalfant, C., Poeta, M.D. (eds) Sphingolipids as Signaling and Regulatory Molecules. Advances in Experimental Medicine and Biology, vol 688. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6741-1_9

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