Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

  • Joost C. M. Holthuis
  • Chiara LubertoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 688)


In the last five years tremendous progress has been made toward the understanding of the mechanisms that govern sphingomyelin (SM) synthesis in animal cells. In line with the complexity of most biological processes, also in the case of SM biosynthesis, the more we learn the more enigmatic and finely tuned the system appears. Therefore with this review we aim first, at highlighting the most significant discoveries that advanced our knowledge and understanding of SM biosynthesis, starting from the discovery of SM to the identification of the enzymes responsible for its production; and second, at discussing old and new riddles that such discoveries pose to current investigators.


Ulatory Molecule Putative Active Site Residue FFAT Motif Liver Nuclear Membrane Synaptic Plasma Membrane Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Membrane Enzymology Bijvoet Center and Institute of BiomembranesUtrecht UniversityUtrechtThe Netherlands
  2. 2.Departments of Biochemistry and Molecular BiologyMedical University of South CarolinaCharlestonUSA

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