Gangliosides as Regulators of Cell Membrane Organization and Functions

  • Sandro Sonnino
  • Alessandro Prinetti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 688)


Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.


Sialic Acid Prion Protein Membrane Domain Neuro2a Cell Chem Phys Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Center of Excellence on Neurodegenerative Diseases Departments of Medical ChemistryBiochemistry and Biotechnology University of MilanSegrateItaly

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