Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum

  • Diego Rojas-Rivera
  • Benjamin Caballero
  • Sebastian Zamorano
  • Fernanda Lisbona
  • Claudio Hetz
Part of the Advances in Experimental Medicine and Biology book series (volume 687)

Abstract

Apoptosis is essential for maintenance of tissue homeostasis and its deregulation results in a variety of disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death that comprises both anti- and pro-apoptotic members, that operate at the mitochondrial membrane to control caspase activation. Different BCL-2-related proteins are also located in the endoplasmic reticulum (ER), where important roles in organelle physiology are proposed. Adaptation to ER stress is mediated by the activation of a complex signal transduction pathway known as the unfolded protein response (UPR). Recent reports indicate that the ER stress sensor IRE1a, signals through the formation of a protein complex platform at the ER membrane, here termed the “UPRosome”. Alternatively, BCL-2 family members are contained in other multiprotein complexes at the ER that are involved in the control of diverse cellular processes including calcium homeostasis, autophagy and ER morphogenesis. Here we describe the emerging concept that BCL-2 family members are important regulators of essential cellular processes beyond apoptosis.

Keywords

Cholesterol Ischemia Leukemia Oligomerization Dition 

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Diego Rojas-Rivera
    • 1
    • 2
  • Benjamin Caballero
    • 1
    • 2
  • Sebastian Zamorano
    • 1
    • 2
  • Fernanda Lisbona
    • 1
    • 2
  • Claudio Hetz
    • 1
    • 2
  1. 1.Program of Cellular and Molecular Biology, The FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of MedicineUniversity of ChileSantiagoChile
  2. 2.Millennium Nucleus for Neural Morphogenesis (NEMO)University of ChileSantiagoChile

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