Breast: Ductal Carcinoma In Situ (DCIS)



Ductal carcinoma in situ (DCIS) of the breast is a proliferation of malignant epithelial cells within parenchymal structures of the breast, which is distinguished from invasive carcinoma by the absence of stromal invasion through the limiting basement membrane. Although the incidence of DCIS has apparently increased over the last 20 years, this is interpreted as a result of the enhanced detection through mammographic breast screening programmes rather than a true increase in frequency of the disease. However, despite the increased numbers of radiologically identified and surgically excised cases, less is understood about the biological and clinical aspects of DCIS than invasive breast cancer. Indeed, research into all aspects, including risk factors, genetics, biology, biomarkers, prognostic factors and the clinical management, of DCIS all lapse behind the significant translational knowledge gained into invasive breast cancer in the last decade.


Invasive Breast Cancer Invasive Carcinoma Atypical Ductal Hyperplasia Flat Epithelial Atypia Architectural Growth Pattern 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Cancer StudiesKing’s College LondonLondonUK

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