The Inflammatory Tissue Microenvironment and the Early Stages of Malignancy

  • Fran Balkwill


The microenvironment has a critical impact on the malignant potential and eventual outcome of a pre-invasive lesion. A tumour-promoting microenvironment contains many of the cells and mediators of chronic inflammation. The origins of this may be extrinsic i.e. inflammatory stimuli cause or exacerbate the evolution of cells with malignant potential, or intrinsic i.e. the oncogenic changes in the initiated cells induce inflammatory pathways.


Papillary Thyroid Carcinoma Malt Lymphoma Chemokine Receptor CXCR4 Inflammatory Microenvironment Human Renal Cell Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Centre for Cancer and Inflammation, Institute of Cancer, Barts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUK

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