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Helicobacter Infection: Infection, Immunity and the Progression of Lesions to Invasive Gastric Cancer

  • Evelyn Kurt-Jones
  • Jean Marie Houghton
Chapter

Abstract

Many malignancies that arise in areas of inflammation progress through a series of architectural changes prior to becoming frankly malignant. These changes are often times linked to the acquisition of distinct genetic defects, and predictably the appearance of distinctive lesions depends upon these changes. Gastric cancer arising from Helicobacter infection is associated with architectural changes similar to those seen in other inflammatory driven malignancies. Tissue progresses from chronic active inflammation to atrophy. Within atrophic mucosa, metaplastic cell types begin to appear, and with long standing disease, adenocarcinoma can result. While temporally associated, it is not clear if the progression of changes from “premalignant” to malignant are causally related. Here we describe the sequence of events leading to the mucosal changes seen, and explore the data which relates these changes to the eventual appearance of gastric adenocarcinoma.

Keywords

Gastric Cancer Gastric Adenocarcinoma Intestinal Metaplasia Parietal Cell Gastric Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cancer BiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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