In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts

  • Jonathan F. Wenk
  • Zhihong Zhang
  • Guangming Cheng
  • Kay Sun
  • Joseph C. Walker
  • David A. SalonerSaloner
  • Mark B. Ratcliffe
  • Julius M. Guccione


A noninvasive method for estimating myocardial material properties in vivo would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent heart failure. Once the material properties for the myocardium are established, the effect of therapeutic changes on regional geometry (i.e., surgical remodeling) and/or material properties (i.e., medicine, gene therapy, and cell therapy) can be evaluated and the success or failure of a proposed therapy predicted. With clinical experience, such a method could be used as a diagnostic modality to risk stratify patients early after a myocardial infarction (MI) who are at risk for adverse remodeling and the development of heart failure.


Left Ventricle Right Ventricle Diastolic Heart Failure Systolic Strain Normal Human Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by National Institutes of Health grants R01 HL077921 and HL086400 (Dr. Guccione).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jonathan F. Wenk
    • 1
  • Zhihong Zhang
  • Guangming Cheng
  • Kay Sun
  • Joseph C. Walker
  • David A. SalonerSaloner
  • Mark B. Ratcliffe
  • Julius M. Guccione
  1. 1.Department of Veterans Affairs Medical CenterSan FranciscoUSA

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