Studies of Therapeutic Strategies for Atrial Fibrillation Based on a Biophysical Model of the Human Atria

  • Laurent Uldry
  • Nathalie Virag
  • Jean-Marc Vesin
  • Lukas Kappenberger


Atrial fibrillation (AF), the most common sustained form of cardiac arrhythmia, is an endemic disease with an increasing prevalence [14, 32]. Its polymorphic dynamical nature severely hampers the development of a single therapy effective in all individual patients [23, 24]. The limited understanding of the AF mechanisms indicates a clear medical need for improving current therapies, adapting them to various AF dynamics that can be found in different patient populations, and selecting the therapy that is optimal for an individual patient.


Atrial Fibrillation Right Atrium Atrial Fibrillation Ablation Biophysical Model Pace Site 



This study was made possible through grants from the Theo-Rossi-Di-Montelera Foundation, Medtronic Europe, and the Swiss Governmental Commission of Innovative Technologies (CTI). The authors wish to thank Ryan Lahm, Drs. Josée Morisette, and Arthur Stillman who kindly furnished the atrial geometry surface model. The authors also would like to thank Prof. Adriaan van Oosterom for helpful discussions and suggestions regarding the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Laurent Uldry
  • Nathalie Virag
    • 1
  • Jean-Marc Vesin
  • Lukas Kappenberger
  1. 1.Medtronic Europe SàrlTolochenazSwitzerland

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