Neurochemical Aspects of Traumatic Brain Injury

  • Akhlaq A. Farooqui


Traumatic brain injury is a silent epidemic and major source of death and disability worldwide in modern society. The Centers for Disease Control and Prevention estimates that approximately 1.4 million US individuals sustain traumatic brain injuries (TBIs) per year of which, approx 50,000 people die from TBI each year and 85,000 people suffer long-term disabilities. In the USA, more than 5.3 million people live with long-term disability with dramatic impacts on their own and their families’ lives. The socioeconomic cost of treating and rehabilitating TBI patients exceeds $56 billion. This economic cost and rate of mortality has generated considerable interest in elucidating the complex molecular mechanism underlying cell death and dysfunction after TBI. Most common causes of TBI are car accidents, bicycle accidents (more than 50%), falls and sport injuries (20–25%), and violence and domestic abuse (including shaken baby syndrome) (20–25%). TBI produces physical, cognitive, emotional, and behavioral effects in the traumatized subject.


Nitric Oxide Nitric Oxide Synthases Traumatic Brain Injury Glial Fibrillary Acidic Protein Neural Cell Adhesion Molecule 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA

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