Potential Neuroprotective Strategies for Experimental Spinal Cord Injury



Spinal cord injury (SCI) is a complex and devastating clinical condition that produces loss of motor and sensory functions below the injury site, often affecting young and healthy individuals throughout the world (Beattie et al., 2000). Functional recovery is very limited because injured axons within the brain and spinal cord are unable to regenerate spontaneously and therapeutic strategies to reestablish lost neuronal connections in spinal cord injury patients are currently unavailable (Schwab et al., 2006; Fouad and Pearson, 2004; Fouad and Tse, 2008). Several factors, including myelin-associated neurite growth inhibitors3, myelin-associated glycoprotein (MAG), myelin-associated glycoprotein (Nogo), and oligodendrocyte-myelin glycoprotein (OMgp), block the regeneration of injured neurons (McKerracher and Winton, 2002; Watkins and Barres, 2002; Filbin, 2003; Watkins and Barres, 2002).


Spinal Cord Spinal Cord Injury Glucocorticoid Receptor Axonal Regeneration Injured Spinal Cord 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA

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