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Neurodegeneration in Neural Trauma, Neurodegenerative Diseases, and Neuropsychiatric Disorders

  • Akhlaq A. Farooqui
Chapter

Abstract

Neurodegeneration is a complex, progressive, and multifaceted process that results in neural cell dysfunction and death in brain and spinal cord. Adult brain and spinal cord contain terminally differentiated postmitotic neurons with downregulated cell division controlling mechanisms (silencing of cyclin-dependent kinases) and upregulated anti-apoptotic mechanisms such as neurotrophic factor signaling, antioxidant enzymes, protein chaperones, anti-apoptotic proteins, and ionostatic systems (Nguyen et al., 2002).

Keywords

Spinal Cord Injury Neurodegenerative Disease Ischemic Injury Traumatic Injury Spinal Muscular Atrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA

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