Surgical Therapy of Disorders of Intrahepatic Cholestasis

  • Peter Mattei


Medical management of patients with certain disorders of intrahepatic cholestasis, including progressive familial intrahepatic cholestasis (PFIC) and Alagille disease, can often delay the need for liver transplantation for many years. Some of these patients, however, develop severe and intractable pruritus, apparently due to excessive serum levels of bile salts. The pruritus can be debilitating, driving some patients to consider suicide.


Bile Salt Internal Hernia Parastomal Hernia Intrahepatic Cholestasis Bile Salt Export Pump 
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Suggested Reading

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.General, Thoracic and Fetal SurgeryThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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