Liver Transplantation



Few subspecialties have undergone the dramatic improvements in survival that have occurred in pediatric liver transplantation. In the early 1980s, survival rates of 30% limited the enthusiasm for this costly and work-intense operation. The introduction of more effective immunosuppression along with refine­ments in the operative and postoperative management of infants and children has improved survival rates to greater than 90%. When compared to the universally fatal outcome these patients would experience without transplantation, it is not surprising that liver transplantation has been embraced as the preferred therapy.


Bile Duct Donor Organ Orthotopic Liver Transplantation Biliary Atresia Portal Vein Thrombosis 
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Suggested Reading

  1. Broelsch CE, Whitington PF, Emond JC, et al. Liver transplantation in children from living related donors. Surgical techniques and results. Ann Surg. 1991;214(4):428–37.CrossRefPubMedGoogle Scholar
  2. Reyes JD, Carr B, Dvorchik I, et al. Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence. J Pediatr. 2000;136(6):795–804.CrossRefPubMedGoogle Scholar
  3. Ryckman F, Fisher R, Pedersen S, et al. Improved survival in biliary atresia patients in the present era of liver transplantation. J Pediatr Surg. 1993;28(3):382–5.CrossRefPubMedGoogle Scholar
  4. SPLIT Research Group. Studies of Pediatric Liver Transplantation (SPLIT): year 2000 outcomes. Transplantation. 2001;72(3):463–76.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Pediatric and Thoracic SurgeryCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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