Fungal Infections Among Patients with AIDS

  • Olivier Lortholary
  • Bertrand Dupont


Fungal infections are the most frequent opportunistic ­diseases occurring during the course of HIV infection. Those mycoses that are usually controlled by cellular immunity are most commonly observed. However, in patients with AIDS, the immune deficit is complex and worsens with time in untreated patients, allowing mycotic diseases to develop [1–3]. Pneumocystis jiroveci and Candida albicans, which are responsible for mucosal candidiasis, and Cryptococcus neoformans, the most frequent cause of meningitis, are the three major fungal pathogens in patients with AIDS [4, 5]. In endemic areas, infections due to dimorphic fungi also ­represent an important group. Histoplasma capsulatum, Coccidioides species, and Penicillium marneffei are the most important endemic pathogens. In some AIDS patients, mycotic disease is often the consequence of reactivation ­several years after a primary infection [6].


Invasive Aspergillosis Minimum Inhibitory Concentration Immune Reconstitution Inflammatory Syndrome Cryptococcal Meningitis Cryptococcal Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Infectious and Tropical Diseases Departement, Centre d’ Infectiologie Necker-PasteurUniversité Paris Descartes, Hôpital Necker Enfants maladesParisFrance

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