Abstract
In Chapter 1, the criteria used to describe the shape and size of beads are explained. In particular, sections on roundness, sphericity, measurement of axial dimensions, and resemblance to geometric bodies are included. A special section is devoted to the methods used to estimate average projected area, volume, and density, including specific gravity balance and pycnometric methods. Other sections are devoted to bead surface area and specific surface in porous media, i.e., dried beads. Also covered are image processing and its utilization for hydrocolloid beads. Finally, the chapter discusses the structure of hydrocolloid beads, their density, and their porosity.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Abramoff, M. D., Magelhaes, P. J., and Ram, S. J. 2004. Image processing with image. J. Biophotonics Int. 11:36–42.
Agnihotri, S. A., Jawalkar, S. S., and Aminabhavi, T. M. 2004. Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. Eur. J. Pharm. Biopharm. 63:249–261.
Agrawal, A. M., Howard, M. A., and Neau, S. H. 2004. Extruded and spheronized beads containing no microcrystalline cellulose: influence of formulation and process variables. Pharm. Dev. Technol. 9:197–217.
Bai, Y. X., and Li, Y. F. 2006. Preparation and characterization of crosslinked porous cellulose beads. Carbohyd. Polym. 64:402–407.
Bajpai, S. K., and Sharma, S. 2004. Investigation of swelling/degradation behavior of alginate beads cross-linked with Ca2+ and Ba2+ ions. React. Funct. Polym. 59:129–140.
Baldyga, J., Bourne, J. R., Pacek, A. W., Amanullah, A., and Nienow, A. W. 2000. Effects of agitation and scale-up on drop size in turbulent dispersions: allowance for intermittency. Chem. Eng. Sci. 56:3377–3387.
Bégin, F., Castaigne, F., and Goulet, J. 1991. Production of alginate beads by a rotative atomizer. Biotechnol. Tech. 5:459–464.
Brandenberger, H., Nüssli, D., Piëch, V., and Widmer, F. 1997. Monodisperse particle production: a new method to prevent drop coalescence using electrostatic forces. J. Electrostat. 45:227–238.
Brandenberger, H., and Widmer, F. 1998. A new multinozzle encapsulation immobilisation system to produce uniform beads of alginate. J. Biotechnol. 63:73–80.
Bugarski, B., Li, Q. L., Goosen, M. F. A., Poncelet, D., Neufeld, R. J., and Vunja, G. 1994. Electrostatic droplet generation: mechanism of polymer droplet formation. AIChE J. 40:1026–1031.
Buitelaar, R. M., Hulst, A. C., and Tamper, J. 1988. Immobilization of biocatalysts in thermogels using the resonance nozzle for rapid drop formation and organic solvents for gelling. Biotechnol. Technol. 2:109–114.
Buthe, A., Hartmeier, W., and Ansorge-Schumacher, A. B. 2004. Novel solvent-based method for preparation of alginate beads with improved roundness and predictable size. J. Microencapsul. 21:865–876.
Cantarella, M., Cantarella, L., and Alfani, F. 1988. Entrapping of acid phosphatase in polyhydroxyethyl methacrylate matrices. Preparation and kinetic properties. Br. Polym. J. 20:477–485.
Curray, J. K. 1951. Analysis of sphericity and roundness of quartz grains. M.Sc. thesis in mineralogy. The Pennsylvania State University, University Park, PA.
Das, S., and Ng, K.-Y. 2010. Resveratrol-loaded calcium-pectinate beads: effects of formulation parameters on drug release and bead characteristics. J. Pharm. Sci. 99:840–860.
Davidson, R. L. 1980. Handbook of Water-Soluble Gums and Resins. New York: McGraw-Hill.
Ghosal, S. K., Talukdar, P., and Pal, T. K. 1993. Standardization of a newly designed vibrating capillary apparatus for the preparation of microcapsulses. Chem. Eng. Technol. 16: 395–398.
Goulden, C. H. 1952. Methods of Statistical Analysis. New York: John Wiley and Sons, Inc.
Green, K. D., Gill, I. S., Khan, J. A., and Vulfson, E. N. 1996. Microencapsulation of yeast cells and their use as a biocatalyst in organic solvents. Biotechnol. Bioeng. 49:535–543.
Griffiths, J. C., and Smith, C. M. 1964. Relationship between volume and axes of some quartzite pebbles from the olean conglomerate Rock City, New York. Am. J. Sci. 262:497–512.
Halle, J. P., Leblond, F. A., Pariseau, J. F., Jutras, P., Brabant, M. J., and Lepage, Y. 1994. Studies on small (less than 300 ?m) microcapsules. II. Parameters governing the production of alginate beads by high-voltage electrostatic pulses. Cell Transplant. 3:365–372.
Houston, R. K. 1957. New criterion of size for agricultural products. Agric. Eng. 39:856–858.
Karathanos, V. T., and Saravacos, G. D. 1993. Porosity and pore size distribution of starch materials. J. Food Eng. 18:259–279.
Kaye, B. 1993. Chaos and Complexity: Discovering the Surprising Patterns of Science and Technology. Weinheim, New York: VCH.
Keppeler, S., Ellis, A., and Jacquier, J. C. 2009. Cross-linked carrageenan beads for controlled release delivery systems. Carbohydr. Polym. 78:973–977.
Kim, S. N., Moritugu, M., Ogata, T., Nonaka, T., and Kurihara, S. 2005. Synthesis and characterization of photochromic liquid crystalline polymer beads. Mol. Cryst. Liq. Cryst. 443:127–135.
Klein, J., Stock, J., and Vorlop, K. D. 1983. Pore size and properties of spherical Ca-alginate biocatalysts. Eur. J. Appl. Microbiol. Biotechnol. 18:86–91.
Kotha, A., Rajan, C. R., Ponrathnam, S., and Shewale, J. G. 1996a. Beaded reactive polymers .1. Effect of synthesis variables on pore size and its distribution in beaded glycidyl methacrylate divinyl benzene copolymers. React. Funct. Polym. 28:227–233.
Kotha, A., Rajan, C. R., Ponrathnam, S., Kumar, K. K., and Shewale, J. G. 1996b. Beaded reactive polymers. 2. Immobilisation of penicillin G acylase on glycidyl methacrylate divinyl benzene copolymers of differing pore size and its distribution. React. Funct. Polym. 28:235–242.
Kotha, A., Raman, R. C., Ponrathnam, S., Kumar, K. K., and Shewale, J. G. 1998. Beaded reactive polymers. 3. Effect of triacrylates as crosslinkers on the physical properties of glycidyl methacrylate copolymers and immobilization of penicillin G acylase. Appl. Biochem. Biotechnol. 74:191–203.
Lai, F., Loy, G., Manconi, M., Manca, M. L., and Fadda, A. M. 2007. Artemisia arborescens L. essential oil loaded beads: preparation and characterization. AAPS PharmaSciTech 8:67.
Levee, M. G., Lee, G. M., Paek, S. H., and Palsson, B. O. 1994. Microencapsulated human bone-marrow cultures: a potential culture system for the clonal outgrowth of hematopoietic progenitor cells. Biotechnol. Bioeng. 43:734–739.
Liu, X. D., Yu, W. Y., Zhang, Y., Xue, W. M., Tu, W. T., Xiong, Y., Ma, X. J., Chen, Y., and Yuan, Q. 2002. Characterization of structure and diffusion behavior of Ca-alginate beads prepared with external or internal calcium sources. J. Microencapsul. 19:775–782.
Lukas, J., Bleha, M., Svec, F., and Kalal, J. 1981. Reactive polymers. XXXVII. An investigation of the internal structure of polymeric sorbents based on poly(2,3epoxypropylmethacrylate-co-ethylene dimethacrylate). Angew. Makromol. Chem. 95:129–137.
Mohsenin, N. N. 1970. Physical Properties of Food and Agricultural Materials. New York: Gordon and Breach.
Mu, Y., Lyddiatt, A., and Pacek, A. W. 2005. Manufacture by water/oil emulsification of porous agarose beads: effect of processing conditions on mean particle size, size distribution and mechanical properties. Chem. Eng. Process. 44:1157–1166.
Musser, G. L., and Burger, W. F. 1997. In Mathematics for Elementary Teachers, a Contemporary Approach, 4th ed., pp. 507–641. Upper Saddle River, NJ: Prentice Hall.
Ni, C. H., Wang, Z., and Zhu, X. X. 2004. Preparation and characterization of thermosensitive beads with macroporous structures. J. Appl. Polym. Sci. 91:1792–1797.
Nussinovitch, A. 1997. Hydrocolloid Applications: Gum Technology in the Food and Other Industries. London and Weinheim: Blackie Academic & Professional.
Nussinovitch, A., and Gershon, Z. 1996. A rapid method for determining sphericity of hydrocolloid beads. Food Hydrocolloids 10:263–266.
O’Connor, S. M., and Gehrke, S. H. 1997. Synthesis and characterization of thermally-responsive hydroxypropyl methylcellulose gel beads. J. Appl. Polym. Sci. 66:1279–1290.
Ogbonna, J. C., Matsumura, M., and Kataoka, H. 1991. Effective oxygenation of immobilized cells through reduction in bead diameter: a review. Process Biochem. 26:109–121.
Okushima, S., Nisisako, T., Torii, T., and Higuchi, T. 2004. Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices Langmuir 20:9905.
Ostberg, T., Lund, E. M., and Graffner, C. 1994. Calcium alginate matrices for oral multiple unit administration: IV. Release characteristics in different media. Int. J. Pharm. 112:241–248.
Perry, R. H., and Chilton, C. H. 1973. Chemical Engineer’s Handbook. New York: McGraw-Hill.
Phillips, G. O., and Williams, P. A. 2000. Handbook of Hydrocolloids. Cambridge, UK: CRC Woodhead Publishing Limited.
Poncelet, D., Bugarski, B., Amsden, B. G., Zhu, J., Neufeld, R., and Goosen, M. F. A. 1994. A parallel-plate electrostatic droplet generator: parameters affecting microbead size. Appl. Microbiol. Biotechnol. 42:251–255.
Poncelet, D., Leung, R., Centomo, L., and Neufeld, R. J. 1993. Microencapsulation of silicone oils within polyamide polyethylenimine membranes as oxygen carriers for bioreactor oxygenation. J. Chem. Technol. Biotechnol. 57:253–263.
Prüsse, U., Fox, B., Kirchhof, M., Bruske, F., Breford, J., and Vorlop, K. D. 1998. New process (jet cutting method) for the production of spherical beads from highly viscous polymer solutions. Chem. Eng. Technol. 21:29–33.
Quenouille, M. H. 1952. Associated Measurements. London: Butterwort-Sprinter, Ltd.
Rayleigh, F. R. S. 1879. On the capillary phenomena of jets. Proc. Lond. Math. Soc. 10:4–13.
Romo, S., and Perez-Martinez, C. 1997. The use of immobilization in alginate beads for long-term storage of Pseudanabaena galeata (Cyanobacteria) in the laboratory. J. Phycol. 33:1073–1076.
Sahin, S. S., and Sumnu, S. G. 2006. Physical Properties of Foods. New York: Springer.
Sankalia, M. G., Mashru, R. C., Sankalia, J. M., and Sutariya V. B. 2006a. Physicochemical characterization of papain entrapped in ionotropically cross-linked kappa-carrageenan gel reads for stability improvement using Doehlert shell design. J. Pharm. Sci. 95:1994–2013.
Sankalia, M. G., Mashru, R. C., Sankalia, J. M., and Sutariya, V. B. 2006b. Stability improvement of alpha-amylase entrapped in kappa-carrageenan beads: physicochemical characterization and optimization using composite index. Int. J. Pharm. 312:1–14.
Seifert, D. B., and Phillips, J. A. 1997. Production of small, monodispersed alginate beads for cell immobilization. Biotechnol. Progr. 13:562–568.
Serp, D., Cantana, E., Heinzen, C., von Stockar, U., and Marison, I. W. 2000. Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol. Bioeng. 70:41–53.
Setoh, M., Hiraoka, K., Nakamura, A. M., Hirata, N., and Arakawa, M. 2007. Collisional disruption of porous sintered glass beads at low impact velocities. Adv. Space Res. 40:252–257.
Shafiur, R. 1995. In Food Properties Handbook, pp. 179–224. Boca Raton, FL: CRC Press.
Siemann, M., Müller-Hurtig, R., and Wagner, F. 1990. Characterization of the rotating nozzle-ring technique for the production of small spherical biocatalysts. Physiology of immobilized cells. In Proc. Int. Symp of Physiology of immobilized cells / edited by J.A.M. de Bont et al., pp. 275–282. Wageningen, The Netherlands: Elsevier Science.
Sipahigil, O., and Dortunc, B. 2001. Preparation and in vitro evaluation of verapamil HCl and ibuprofen containing carrageenan beads. Int. J. Pharm. 228:119–128.
Smidsrod, O., and Skjak-Braek, G. 1990. Alginate as immobilization matrix for cells. Trends Biotechnol. 8:71–78.
Sughi, H., Esumi, K., Honda, H., and Oda, H. 1995. Characterization of carbonaceous gel beads prepared in presence of polymer using water-in-oil emulsion. Carbon 33:821–825.
Takeuchi, S., Garstecki, P., Weibel, D. B., and Whitesides, G. M. 2005. An axisymmetric flow-focusing microfluidic device. Adv. Mater. 17:1067.
Tan, W. H., and Takeuchi, S. 2007. Monodisperse alginate hydrogel microbeads for cell encapsulation. Adv. Mater. 19:2696.
Tosa, T., Sato, T., Mori, T., Yamamoto, K., Takata, I., Nishida, Y., and Chibata, I. 1979. Immobilization of enzymes and microbial-cells using carrageenan as matrix. Biotechnol. Bioeng. 21:1697–1709.
Walsh, P. K., Isdell, F. V., Noone, S. M., Odonovan, M. G., and Malone, D. M. 1996. Growth patterns of Saccharomyces cerevisiae microcolonies in alginate and carrageenan gel particles: effect of physical and chemical properties of gels. Enzyme Microb. Tech. 18:366–372.
Wang, D. M., Hao, G., Shi, Q. H., and Sun, Y. 2007. Fabrication and characterization of superporous cellulose bead for high-speed protein chromatography. J. Chromatogr. A 1146:32–40.
Weber, C. 1931. Zum Zerfall eines Flu¨ssigkeitstahles. Z. Angew. Math Mech. 11:136–155.
Weisstein, E. W. 2003. CRC Concise Encyclopedia of Mathematics, 2nd ed. Boca Raton, FL: CRC Press.
Wolf, B., and Finke, I. 1992. The use of bead celluloses as carrier for controlled liberation of drugs. 5. Binding of benzocanie as a model-drug to dialdehyde bead cellulose and its in vitro liberation. Pharmazie 47:121–125.
Wong, T. W., and Nurjaya, S. 2008. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave. Eur. J. Pharm. Biopharm. 69:176–188.
Woo, J. W., Roh, H. J., Park, H. D., Ji, C. I., Lee, Y. B., and Kim, S. B. 2007. Sphericity optimization of calcium alginate gel beads and the effects of processing conditions on their physical properties. Food Sci. Biotechnol. 16:715–721.
Yilmaz, E., and Bengisu, M. 2003. Preparation and characterization of physical gels and beads from chitin solutions. Carbohyd. Polym. 54:479–488.
Zhang, J., Wang, W. Q., Wang, Y. P., Zeng, J. Y., Zhang, S. T., Lei, Z. Q., and Zhao, X. T. 2007. Preparation and characterization of montmorillonnite/carrageen/guar gum gel spherical beads. Polym. Polym. Compos. 15:131–136.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Nussinovitch, A. (2010). Physical Properties of Beads and Their Estimation. In: Polymer Macro- and Micro-Gel Beads: Fundamentals and Applications. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6618-6_1
Download citation
DOI: https://doi.org/10.1007/978-1-4419-6618-6_1
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-6617-9
Online ISBN: 978-1-4419-6618-6
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)