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Collagen in Cancer

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The Tumor Microenvironment

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Collagen is a key structural component of the extracellular matrix (ECM), and also serves as a modular of diverse signaling pathways. Intact collagens may be upregulated in cancer to provide a rigid matrix that facilitates tumor growth. In turn, collagen catabolism by matrix metalloproteinases (MMPs) and other proteases reveals previously hidden binding sites that promote angiogenesis and tumor invasion. A variety of cell surface biomolecules (integrins, CD44, DDRs) and other ECM proteins and proteoglycans [fibronectin (FN), laminin (LNs), decorin] interact with collagen, and these interactions, along with the structural state of collagen, provide the foundation for tumorigenesis and metastasis.

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Acknowledgments

We gratefully acknowledge the National Institutes of Health (CA98799, EB000289, and MH078948), the Robert A. Welch Foundation, and the Texas Higher Education Science and Technology Acquisition and Retention (STAR) Award (all to GBF) for support of our research on collagen and metalloproteases and the National Institutes of Health NIDCR (DE14318) COSTAR Program (to JL).

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  1. Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA

    Gregg B. Fields

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  1. Janelle L. Lauer
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    Rebecca G. Bagley

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Lauer, J.L., Fields, G.B. (2010). Collagen in Cancer. In: Bagley, R. (eds) The Tumor Microenvironment. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6615-5_23

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