Intracellular and Intercellular Cross Talk Between NGF and TNF

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


It is well established that tumour necrosis factor α (TNFα) is a pro-inflammatory cytokine that can induce apoptosis in neuronal cells through TNFα receptor (TNFR) 1. However, there is substantial, but controversial evidence that TNFα can promote survival of neuronal cells through another receptor TNFR2. We recently reported that TNFα expression can be induced in neuronal cells by nerve growth factor (NGF), a neurotrophin that can promote neural cell survival, differentiation and maturation. The endogenous TNFα induced by NGF makes a positive loop of Akt activation through TNFR2, promoting survival of normal neural cells. Simultaneously, this loop suppresses Erk activation by NGF, blocking NGF-induced differentiation of neuroblastoma cells. In this chapter, we explain this new cross talk between NGF and TNFα and propose a positive loop of TNFα and NGF expression between glial and neuronal cells.


Nerve Growth Factor Neuroblastoma Cell Line Nerve Growth Factor Expression Positive Loop Nerve Growth Factor Signalling 
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This work was supported by the Alzheimer’s Research Trust, the Medical Research Council and Cancer Research UK.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.MRC Cancer Cell UnitHutchison/MRC Research CentreCambridgeUK
  2. 2.Department of Genomic Drug Discovery ScienceGraduate School of Pharmaceutical Sciences, Kyoto UniversityKyotoJapan

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