The Contribution of TNFα to Synaptic Plasticity and Nervous System Function

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)

Abstract

The immune and nervous systems are generally thought to operate independently; however, evidence is accumulating proving that they interact in a variety of important ways. Recently, it has become clear that many immune molecules are used constitutively by the nervous system as signaling molecules, and disruption of this signaling through immunological challenge can contribute to neuronal dysfunction [1, 2]. One such example would be the pro-inflammatory cytokine tumor necrosis factor α (TNFα), principally known for its role in the inflammatory signaling cascade of immune cells.

Keywords

Depression Retina Neuropathy NMDA Fluoxetine 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Centre for Research in Neuroscience, McGill UniversityMontrealCanada

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