Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR

  • Tatsushi Igaki
  • Hiroshi Kanda
  • Hideyuki Okano
  • Tian Xu
  • Masayuki Miura
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger’s TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.


Neuronal Cell Death Imaginal Disc Nociceptive Sensitization Hydrophobic Transmembrane Domain Downstream Signaling Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Tatsushi Igaki
    • 1
  • Hiroshi Kanda
    • 2
  • Hideyuki Okano
    • 2
  • Tian Xu
    • 3
  • Masayuki Miura
    • 4
    • 5
  1. 1.Department of Cell Biology, G-COEKobe University Graduation School of MedicineKobeJapan
  2. 2.Department of PhysiologyKeio University School of MedicineTokyoJapan
  3. 3.Department of GeneticsHoward Hughes Medical Institute, Yale University School of MedicineNew HavenUSA
  4. 4.Department of GeneticsGraduate School of Pharmaceutical Sciences, The University of TokyoTokyoJapan
  5. 5.CREST, JSTTokyoJapan

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