Involvement of the Cytokine Receptor CD137 in Murine Hematopoiesis

  • Dongsheng Jiang
  • Qianqiao Tang
  • Herbert Schwarz
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


CD137 and CD137 ligand are members of the tumor necrosis factor (TNF) receptor and TNF family, respectively. CD137 is expressed by cells in the bone marrow and CD137 ligand is expressed on hematopoietic progenitor cells. The interaction of CD137 and CD137 ligand induced proliferation and colony formation of hematopoietic progenitor cells and their differentiation to macrophages. Since CD137 is expressed on activated immune cells the CD137-induced myelopoiesis may take place during ongoing immune responses. However, in a steady-state condition the CD137 receptor/ligand system seems to inhibit myelopoiesis. Current data only indicate an involvement of CD137 and its ligand in myelopoiesis while other hematopoietic lineages are not affected.


Bone Marrow Cell CD137 Ligand Hematopoietic Progenitor Cell Osteoclast Progenitor Diacetate Succinimidyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Part of this chapter is based on Jiang et al. [8]. Copyright 2008. The American Association of Immunologists, Inc.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dongsheng Jiang
    • 1
  • Qianqiao Tang
    • 1
  • Herbert Schwarz
    • 1
  1. 1.Department of Physiology and Immunology ProgrammeYong Loo Lin School of Medicine, National University of SingaporeSingaporeSingapore

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