The Role of TNFRSF25:TNFSF15 in Disease… and Health?

  • Taylor H. Schreiber
  • Dietlinde Wolf
  • Eckhard R. Podack
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


TNFRSF25 (DR3) is one of the most recently discovered TNF superfamily receptors and includes an intracellular death domain required to initiate signaling. Over the past decade significant progress has been made in defining the characteristics of this receptor, including the identification of its ligand, TNFSF15 (TL1A). Although TL1A can be provided from a number of sources, signaling through TNFRSF25 is primarily concentrated on T cells. TNFRSF25 signaling can lower the threshold for TCR-induced cell proliferation or cytokine production in an IL-2-dependent manner as well as amplify cytokine production initiated by IL-12 and IL-18. In vivo, TNFRSF25:TL1A signaling has been associated with a number of autoinflammatory conditions including allergic asthma, experimental autoimmune encephalomyelitis, type 1 diabetes, rheumatoid arthritis, and inflammatory bowel disease. Here we discuss the short history of TL1A:TNFRSF25 in health and disease states, including several exciting new observations reported at the 12th international TNF conference, 2009.


Dextran Sodium Sulfate Death Domain Experimental Allergic Encephalomyelitis Germ Line Deletion Ligand Pair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



tumor necrosis factor


tumor necrosis factor superfamily


tumor necrosis factor superfamily receptor


effector T cell


regulatory T cell


bovine serum albumin




rheumatoid factor


dextran sodium sulfate


kilo Dalton


amino acid


peripheral blood lymphocytes


extra-cellular domain


natural killer


natural killer T cell


toll like receptor


TNF receptor associated death domain


Fas associated death domain


receptor interacting protein


nuclear factor kappa beta




T cell receptor


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Taylor H. Schreiber
    • 1
  • Dietlinde Wolf
    • 1
  • Eckhard R. Podack
    • 1
  1. 1.Sheila and David Fuentes Program in Cancer Biology, Department of Microbiology and ImmunologyUniversity of Miami Miller School of MedicinMiamiUSA

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