Poxviral TNFRs: Properties and Role in Viral Pathogenesis

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


Tumor necrosis factor (TNF) is the prototypical member of a large superfamily of structurally related cytokines that are involved in a wide range of activities involved in the regulation of the immune response and developmental processes and that signal mainly through an equally diverse array of receptors included in the TNF receptor superfamily (TNFRSF). TNF has an essential role in the activation of the antiviral immune response, where it acts both directly on virus-infected cells as a cell death-inducing cytokine and indirectly in the activation of the innate and adaptive immune responses against the invading pathogen. Consequently, viruses from different families have devised strategies to evade or modulate these TNF-driven responses. Most strategies involve the expression of virus-encoded intracellular proteins that are able to bind to different proteins of the TNFR signal transduction pathways. Uniquely, poxviruses express secreted TNFR homologues that can bind to soluble TNF, inhibiting its activity by preventing it from binding to the cellular receptors. In the recent years, we have been interested in studying the activity and function of these viral TNFRs (vTNFRs) both in vitro and during infection. We describe recent advances in this field.


Tumor Necrosis Factor Antiviral Immune Response Molluscum Contagiosum Myxoma Virus Main Target Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Alí Alejo
    • 1
  • Sergio M. Pontejo
    • 2
  • Antonio Alcami
    • 3
  1. 1.Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaMadridSpain
  2. 2.Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid)MadridSpain
  3. 3.Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid)MadridSpain

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