Unique Personalities Within the NF-κB Family: Distinct Functions for p65 and RelB in the Osteoclast
The osteoclast (OC) is the resorptive cell of the skeleton responsible for both normal homeostasis and pathological bone loss. NF-κB is a critical signal for OC differentiation downstream of RANKL, and its global disruption protects mice from pathological bone loss. Differently from other TNF family members, RANKL activates both the classical NF-κB pathway, activating both p65 and cRel, and the alternative pathway, inducing expression and activation of RelB. In order to determine whether the classical and alternative NF-κB pathways have distinct roles in OC differentiation, we examined mice lacking p65, RelB, or cRel.
KeywordsResorptive Cell Form Actin Ring Radiation Chimera Murine Tumor Cell Line Inflammatory Osteolysis