Unique Personalities Within the NF-κB Family: Distinct Functions for p65 and RelB in the Osteoclast

  • Deborah Veis Novack
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


The osteoclast (OC) is the resorptive cell of the skeleton responsible for both normal homeostasis and pathological bone loss. NF-κB is a critical signal for OC differentiation downstream of RANKL, and its global disruption protects mice from pathological bone loss. Differently from other TNF family members, RANKL activates both the classical NF-κB pathway, activating both p65 and cRel, and the alternative pathway, inducing expression and activation of RelB. In order to determine whether the classical and alternative NF-κB pathways have distinct roles in OC differentiation, we examined mice lacking p65, RelB, or cRel.


Resorptive Cell Form Actin Ring Radiation Chimera Murine Tumor Cell Line Inflammatory Osteolysis 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Bone and Mineral Diseases, Departments of Medicine and PathologyWashington University School of MedicineSt. LouisUSA

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