Clinical Aspects of Juvenile Polyposis

  • Daniel Calva
  • James R. HoweEmail author
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)


Juvenile polyposis (JP) is a hamartomatous polyposis syndrome, characterized by autosomal dominant transmission. Patients with JP have a propensity to develop polyps throughout the large bowel, and some will also develop these in the upper GI tract. The polyps can be numerous or few, and are not adenomas, as seen in familial adenomatous polyposis. The disease can be familial or sporadic (non-familial), and there is an increased risk for cancer of the GI tract. In this chapter, we will review the history, clinical features, histopathology, risk of malignancy, therapeutic options, and genetics of JP.


Hereditary Mixed Polyposis syndrome Multiple Adenoma Patients 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Surgical Oncology and Endocrine SurgeryRoy J. and Lucille A. Carver University of Iowa College of MedicineIowa CityUSA

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