History: Familial Adenomatous Polyposis

  • Susan K. Clark
  • Kay F. Neale
  • Robin K. S. PhillipsEmail author
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)


This chapter sets out to describe the developments leading to our current knowledge of familial adenomatous polyposis. An appreciation of historical context allows an enhanced understanding of contemporary paradigms and management of this condition.


Familial Adenomatous Polyposis History Colorectal Cancer 


  1. 1.
    Chargelaigue. Des Polypes du Rectum. Thesis. Paris; 1859.Google Scholar
  2. 2.
    Cripps H. Two cases of disseminated polypus of rectum. Trans Pathol Soc Lond. 1882;33:165.Google Scholar
  3. 3.
    Whitehead W. Multiple adenomas of the rectum and colon. Br Med J 1884;1;410.CrossRefGoogle Scholar
  4. 4.
    Dalton N. Multiple papillomata of the colon and rectum. Lancet. 1893;1:146.Google Scholar
  5. 5.
    Curling TB. Observations on the diseases of the rectum. Philadelphia; Lindsay and Blakiston; 1876.Google Scholar
  6. 6.
    Allingham W. Diagnosis and treatment of diseases of the rectum. London; 1888.Google Scholar
  7. 7.
    Boas I. Diagnostik und Therapie der Darmkrankheiten. Leipzig; 1901.Google Scholar
  8. 8.
    Erdmann JF, Morris JH. Polyposis of the colon. Surg Gynecol Obstet. 1925;40:460.Google Scholar
  9. 9.
    Lockhart-Mummery JP. Diseases of the rectum and colon. London; 1923.Google Scholar
  10. 10.
    Dukes C. The hereditary factor in polyposis intestine, or multiple adenomata. Cancer Rev. 1930;5:241–51.Google Scholar
  11. 11.
    Smith T. Three cases of multiple polypi of the lower bowel occurring in one family. St Bartholomew’s Hosp Rep. 1887;23:225.Google Scholar
  12. 12.
    Bickersteth RA. Multiple polypi of the rectum occurring in a mother and child. St Bartholomew’s Hosp Rep. 1890;26:299.Google Scholar
  13. 13.
    Cockayne EA. Heredity in relation to cancer. Cancer Rev. 1927;2:337–47.Google Scholar
  14. 14.
    Handford H. Disseminated polypi of the large intestine becoming malignant. Trans Pathol Soc Lond. 1890;41:133.Google Scholar
  15. 15.
    Lockhart-Mummery P. Cancer and heredity. Lancet. 1925;1:427–9.CrossRefGoogle Scholar
  16. 16.
    Bussey HJR. Historical developments in familial adenomatous polyposis. In: Herrera L, editor. familial adenomatous polyposis. New York, NY: Alan Liss; 1990. p. 1–7.Google Scholar
  17. 17.
    Alm T. Surgical treatment of hereditary adenomatosis of the colon and rectum in Sweden during the last 20 years. Acta Chir Scand. 1975;141:218–37.PubMedGoogle Scholar
  18. 18.
    Macrae FA, St John DJ, Muir EP, et al. Impact of a hospital-based register on the management of familial adenomatous polyposis. Med J Aust. 1989;151:549–57.Google Scholar
  19. 19.
    Nugent KP, Spigelman AD, Phillips RKS. Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Dis colon Rectum. 1993;36:1059–62.PubMedCrossRefGoogle Scholar
  20. 20.
    Bulow S. Results of national registration of familial adenomatous polyposis. Gut. 2003;52:742–6.PubMedCrossRefGoogle Scholar
  21. 21.
    Northover JMA. Activities of the Leeds Castle Polyposis Group. Semin Surg Oncol. 1987;3:118–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Cabot RC, editor. Case records of the Massachusetts General Hospital: case 21061. N Engl J Med. 1935;212:2637.Google Scholar
  23. 23.
    Nichols RW. Desmoid tumours. Arch Surg. 1923;7:227–36.CrossRefGoogle Scholar
  24. 24.
    Gardner EJ, Richards RC. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet. 1953;5:139–47.PubMedGoogle Scholar
  25. 25.
    Kingston JE, Herbert A, Draper GJ, et al. Association between hepatoblastoma and polyposis coli. Arch Dis Child. 1983;58:959–62.PubMedCrossRefGoogle Scholar
  26. 26.
    Plail RO, Glazer G, Thomson JPS, et al. Adenomatous polyposis: An association with carcinoma of the thyroid? Br J Surg. 1985;72 (Suppl.):138.Google Scholar
  27. 27.
    Wallace MH, Phillips RKS. Upper gastrointestinal disease in patients with familial adenomatous polyposis. Br J Surg. 1998;85:742–50.PubMedCrossRefGoogle Scholar
  28. 28.
    Johnson Smith TGP, Clark SK, Katz DE, et al. Adrenal masses are associated with familial adenomatous polyposis. Dis Colon Rectum. 2000;43:1739–42.CrossRefGoogle Scholar
  29. 29.
    Belchez LA, Berk T, Bapat BV, et al. Changing causes of mortality in patients with familial adenomatous polyposis. Dis Colon Rectum. 1996;39:384–7.CrossRefGoogle Scholar
  30. 30.
    Bussey HJR. Familial polyposis coli. Family studies, histopathology, differential diagnosis, and results of treatment. Baltimore, MD: The Johns Hopkins University Press; 1975.Google Scholar
  31. 31.
    Dukes C. Simple tumours of the large intestine and their relation to cancer. Br J Surg. 1925;13:720–33.CrossRefGoogle Scholar
  32. 32.
    Muto T, Bussey HJR, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36:2251–70.PubMedCrossRefGoogle Scholar
  33. 33.
    Smith WG. Familial multiple polyposis: research tool for investigating the etiology of carcinoma of the colon. Dis Colon Rectum. 1968;11:17–31.PubMedCrossRefGoogle Scholar
  34. 34.
    Fearon ER, Vogelstein B. A model for colorectal tumourigenesis. Cell. 1990;61:759–67.PubMedCrossRefGoogle Scholar
  35. 35.
    Steinbach G, Lynch P, Phillips RKS, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000;342(26):1946–58.PubMedCrossRefGoogle Scholar
  36. 36.
    Lockhart-Mummery JP. The causation and treatment of multiple adenomatosis of the colon. Ann Surg. 1943;99:178–84.CrossRefGoogle Scholar
  37. 37.
    Thomson JPS. Familial adenomatous polyposis: the large bowel. Ann R Coll Surg Engl. 1990;72:177–80.PubMedGoogle Scholar
  38. 38.
    Rankin FW. Total colectomy: Its indication and technic. Ann Surg. 1931;94:677–704.PubMedCrossRefGoogle Scholar
  39. 39.
    Mayo CW, Wakefield EG. Disseminated polyposis of the colon: A new surgical treatment in selected cases. JAMA. 1936;107:342–8.CrossRefGoogle Scholar
  40. 40.
    McKenney DC. Multiple polyposis: Congenital, heredofamilial, malignant. Am J Surg. 1939;46:204–6.CrossRefGoogle Scholar
  41. 41.
    Dukes CE. Familial intestinal polyposis. Ann R Coll Surg Engl. 1952;10:293–304.PubMedGoogle Scholar
  42. 42.
    Lockhart-Mummery H. Intestinal polyposis: the present position. Proc R Soc Med. 1967;60:381–8.PubMedGoogle Scholar
  43. 43.
    Moertel CG, Hill JR, Adson MA. Surgical management of multiple polyposis. Arch Surg. 1970;100:521–6.PubMedCrossRefGoogle Scholar
  44. 44.
    Nugent KP, Phillips RKS. Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: A cause for concern. Br J Surg. 1992;79:1204–6.PubMedCrossRefGoogle Scholar
  45. 45.
    Parks AG, Nicholls RJ. Proctocolectomy without ileostomy for ulcerative colitis. Br Med J. 1978;2:85–8.PubMedCrossRefGoogle Scholar
  46. 46.
    Madden MV, Neale KF, Nicholls RJ, et al. Comparison of morbidity and function after colectomy with ileorectal anastomosis or restorative proctocolectomy for familial adenomatous polyposis. Br J Surg. 1991;78:789–92.PubMedCrossRefGoogle Scholar
  47. 47.
    Olsen KØ, Juul S, Bülow S, et al. Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg. 2003;90:227–31.PubMedCrossRefGoogle Scholar
  48. 48.
    Heuschen UA, Heuschen G, Autscbach F, et al. Adenocarcinoma in the ileal pouch: Late risk after restorative proctocolectomy. Int J Colorectal Dis. 2001;16:126–30.PubMedCrossRefGoogle Scholar
  49. 49.
    Church J, Burke C, McGannon E, et al. Risk of rectal cancer after colectomy and ileorectal anastomosis for familial adenomatous polyposis: A function of available options. Dis Colon Rectum. 2003;46:1175–81.PubMedCrossRefGoogle Scholar
  50. 50.
    Wexner SD, Johansen OB, Nogueras JJ, et al. Laparoscopic total abdominal colectomy: A prospective trial. Dis Colon Rectum. 1992;35:651–5.PubMedCrossRefGoogle Scholar
  51. 51.
    Herrera L, Kakati S, Gibas L, et al. Gardner’s Syndrome in a man with an interstitial deletion of 5q. Am J Med Genet. 1986;25:473–6.PubMedCrossRefGoogle Scholar
  52. 52.
    Bodmer WF, Bailey CJ, Bodmer J, et al. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature. 1987;328(6131):614–6.PubMedCrossRefGoogle Scholar
  53. 53.
    Kinzler KV, Nilbert MC, Su LK, et al. Identification of FAP locus genes from Chromosome 5q21. Science. 1991;253(5020):661–5.PubMedCrossRefGoogle Scholar
  54. 54.
    Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classic adenomatous polyposis and germ-line mutations in MYH. N Engl J Med. 2003;348:791–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Susan K. Clark
  • Kay F. Neale
  • Robin K. S. Phillips
    • 1
    Email author
  1. 1.The Polyposis RegistrySt Mark’s HospitalHarrowUK

Personalised recommendations