Kernicterus pp 81-93 | Cite as

Neuropathology of Kernicterus

  • David W. McCandless
Part of the Contemporary Clinical Neuroscience book series (CCNE)


In one early paper (Zuelzer, W., and Mudgett, R. 1950) two groups of a total of 55 kernicteric newborn infants were compared as regards etiology, laboratory data, and neuropathology. One group of patients consisted of 23 cases, all kernicteric and associated with erythroblastosis fetalis, and a second group of 32 cases, not associated with erythroblastosis, but associated with a variety of other suspected causes.


Newborn Infant Hippocampal Slice Auditory Brainstem Response Cochlear Nucleus Dorsal Cochlear Nucleus 
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  1. Ahdab-Barmada, M., and Moossy, J. (1984) Theneuropathology of kernicterus in the premature neonate: diagnostic problems. J. Neuropath. Expt. Neurol. 43:45–56CrossRefGoogle Scholar
  2. Blanc, W., (1961) Kernicterus in Gunn’s strain of rats. In Kernicterus, Sass-Kortsak, A. ed. University of Toronto Press, Toronto, ON, pp 150–152Google Scholar
  3. Burke, B., et al. (2009) Trends in hospitalization for neonatal jaundice and kernicterus in the United States, 1988–2005. Pediatr. 123:524–532CrossRefGoogle Scholar
  4. Claireaux, A. (1961) Pathology of human kernicterus. In Sass-Kortsak, A. ed. Kernicterus. University of Toronto press, Toronto, ONGoogle Scholar
  5. Funato, M., et al. (1994) Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatr. 93:50–53Google Scholar
  6. Gupta, A. and Mann, S. (1998) Is auditory brainstem response a bilirubin toxicity marker? Am. J. Otolaryngol. 19:232–236PubMedCrossRefGoogle Scholar
  7. Hansen, T., and Cashore, W. (1995) Rates of bilirubin clearance from rat brain regions. Biol. Neonate. 68:135–140PubMedCrossRefGoogle Scholar
  8. Jew, J., and Williams, T. (1977) Ultrastructeral aspects of bilirubin encephalopathy in cochlear nuclei of the Gunn rat. J. Anat. 124:599–616PubMedGoogle Scholar
  9. Rozdilsky, B. (1961) Experimental studies on the toxicity of bilirubin. In Kernicterus. Sass-Kortsak, A. ed. University of Toronto press, Toronto, ONGoogle Scholar
  10. Shapiro, S. (2003) Bilirubin toxicity in the developing nervour system. Pediatr. Neurol. 29:410–421PubMedCrossRefGoogle Scholar
  11. Vietti, T. (1961) The in vivo crystallization of bilirubin in hyperbilirubinaemic infants. In Kernicterus. Sass-Kortsak, A. ed. University of Toronto press, Toronto, ONGoogle Scholar
  12. Wennberg, R. (2000) The blood brain barrier and bilirubin encephalopathy. Cell. Mol. Neurobiol. 20:97–109PubMedCrossRefGoogle Scholar
  13. WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50Google Scholar
  14. Zuelzer, W., and Mudgett, R. (1950) Kernicterus: Etiologic study based on an analysis of 55 cases. Pediat. 6:452–474Google Scholar
  15. Schmid, R., et al. (1958) Congenital jaundice in rats due to a defect in glucuronide formation. J. Clin. Invest. 37:1123–1130PubMedCrossRefGoogle Scholar
  16. Lee, C., et al. (1995) Postnatal maturation of the blood brain barrier for unbound bilirubin in newborn piglets. Brain Res. 689:233–238PubMedCrossRefGoogle Scholar
  17. Chang, F.-Y., et al. (2009) Unconjugated bilirubin exposure impairs hippocampal long term synaptic plasticity. PLoS ONE 4(6):e5876PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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