Kernicterus pp 65-79 | Cite as

Crigler–Najjar Syndrome

  • David W. McCandless
Part of the Contemporary Clinical Neuroscience book series (CCNE)


In 1952 (Crigler, J., and Najjar, V. 1952), the initial report of a congenital abnormality of the liver-conjugating system was first described by the two investigators whose name the disorder carries. This paper reports seven patients, all descendents of two people, six generations back. Five of the patients were studied directly, one was in another hospital, and one was diagnosed by a careful history, but not examined by the authors. Complete genetic studies were not completed at the time of publication. It was suggested that 15 probable cases existed out of 105 family members over the six generations.


Bilirubin Level Total Serum Bilirubin Serum Bilirubin Level Unconjugated Bilirubin Hepatocyte Transplantation 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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