Abstract
Hemolytic disease of the newborn (HDN) is a collective phrase which includes several acquired hemolytic anemias, of which erythroblastosis fetalis is one. The term erythroblastosis fetalis, applies to Rh isoimmunization resulting in hemolysis, but the term focuses on aspects of the disease which are not always specific or present in each case. This chapter will therefore refer to HDN to describe red blood cell hemolytic anemias. In a very general and obvious way, hemolytic anemias in the newborn can be deleterious because they represent an increase in bilirubin formation at a time when the newborn liver may not be enzymatically equipped to conjugate the pigment, facilitating its excretion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Altman, K. (1959) Some enzymologic aspects of the human erythrocyte. Am. J. Med. 23:936–951
Beutler, E. (2006) Disorders of red cells resulting from enzyme abnormalities. In Williams hematology. Lichtman, M., et al. eds. McGraw Hill, New York, NY, pp 603–631
Bevis, D. (1953) The composition of liquor amnii in haemolytic disease of the newborn. J. Obstet. Gynaec. Brit. Emp. 60:244–250
Brazie, J., Ibbott, F., and Bowes, W. (1966) Identification of the pigment in amniotic fluid of erythrocytes as bilirubin. J. Pediat. 69:354–358
Claireaux, A., Cole, P., and Lathe, G.(1953) Icterus of the brain in the newborn. Lancet 4:1226–1230
Gardos, G., and Straub, F. (1957) Uber die rolle der ATP in der K-permeabilitat der menschlichen roten blutkorperchen. Acta physiol. Hung. 12:1–12
Hollingsworth, J. (1955) Lifespan of fetal erythrocytes. J. Lab. Clin. Med. 45:469–473
Hyman, C., et al. (1969) CNS abnormalities after neonatal hemolytic disease or hyperbilirubinemia. Am. J. Dis. Child. 117:395–405
Rapoport, S., and Luebering, J. (1950) The formation of 2,3-diphosphoglycerate in rabbit erythrocytes. J. Biol. Chem. 183:507–520
WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50
Jirsova, V., Jirsa, M., and Janovsky, M. (1958) Importance of the quantitative determination of direct and indirect bilirubin in hemolytic diseasr of the newborn. Acta Pediat. 47:179–186
Blackfan, K. Diamond, L., and Leister, C. (1944) Atlas of blood in children. The Commonwealth Fund, Oxford University Press, London
Rapoport, S., and Nieradt, C. (1951) Glycerate-2–3-diphosphatase. J. Biol. Chem. 189:683–691
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
McCandless, D.W. (2011). Erythroblastosis Fetalis. In: Kernicterus. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4419-6555-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4419-6555-4_5
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4419-6554-7
Online ISBN: 978-1-4419-6555-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)