Kernicterus pp 245-250 | Cite as

Epilogue: Comments and Future Directions

  • David W. McCandless
Part of the Contemporary Clinical Neuroscience book series (CCNE)


The study of unconjugated hyperbilirubinemia, and resultant kernicterus is a highly interesting and important endeavor. This area of investigation has been an active one for well over a 100 years, and occupied the minds of many outstanding scientists.


Cerebral Palsy Newborn Infant Auditory Brainstem Response Kainic Acid Hydroxy Fatty Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Butcher, R., Stutz, R., and Berry, H. (1971) Behavioral abnormalities in rats with neonatal jaundice. Am. J. Ment. Def. 75:755–759Google Scholar
  2. Chavko, M., and Nemoto, E. (1992) Regional differences in rat brain lipids during global ischemia. Stroke 23:1000–1004PubMedCrossRefGoogle Scholar
  3. Dal-Pizzol, F., et al. (2007) Changes in lipid composition in hippocampus early and late after status epilepticus induced by kainic acid in wister rats. Metab. Brain Dis. 22:25–29PubMedCrossRefGoogle Scholar
  4. Miranda, P., and Bosma, P. (2009) Towards liver-directed gene therapy for Crigler-Najjar syndrome. Curr. Gene ther. 2:72–82CrossRefGoogle Scholar
  5. Nguyen, T., et al. (2007) Critical assessment of lifelong phenotype correction in hyperbilirubinemic Gunn rats after retroviral mediated gene transfer. Gene Ther. 17:1270–1277CrossRefGoogle Scholar
  6. WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50Google Scholar
  7. Winter, S., et al. (2002) Trends in the prevalence of cerebral palsy in a population based study. Pediatr. 110:1220–1225CrossRefGoogle Scholar
  8. Tolmacheva, E., and van Luijtelaar, G. (2007) Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats. Neurosci. Lett. doi: 10.1016/j.neulet.2007.01.038Google Scholar
  9. Nguyen, T., and Ferry, P. (2007) Gene therapy for liver enzyme deficiencies: what have we learned from models for Crigler-Najjar and tyrosinemia? Expert. Rev. Gastroent. Hepatol. 1:155–171CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

Personalised recommendations