Kernicterus pp 235-244 | Cite as

Gene Therapy for Hyperbilirubinemia

  • David W. McCandless
Part of the Contemporary Clinical Neuroscience book series (CCNE)


The term “gene therapy” is used to designate a process in which viruses are used to carry specific genetic information into a cell, thereby transducing the cells’ function. In\the case of the Crigler–Najjar syndrome, and the Gunn rat, the absence of the bilirubin-conjugating enzyme glucuronosyl transferase can be corrected in cells infected by the modified viral vectors. Overall the numbers of inborn errors of metabolism susceptible to treatment with gene therapy, as well as the potential treatment of other types of disorders will be highly significant.


Gene Therapy Enzyme Replacement Therapy Partial Hepatectomy Unconjugated Bilirubin Unconjugated Hyperbilirubinemia 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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