Skip to main content
SpringerLink
Log in

Kernicterus in Older Children and Adults

  • Chapter
  • First Online:
Kernicterus

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

  • 1012 Accesses

Abstract

Kernicterus represents a metabolic encephalopathy afflicting newborns and children with unconjugated hyperbilirubinemia. Also occurring are several types of hyperbilirubinemia with both unconjugated and conjugated present in the serum.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Auclair, C., et al. (1976) Bilirubin and paranitrophenol glucuronyl transferase activities and ultrastructural aspect of the liver in patients with chronic hemolytic anemias. Biomedicine 25:61–72

    PubMed  CAS  Google Scholar 

  • Berk, P. (1970) Constitutional hepatic dysfunction (Gilbert’s syndrome) Am. J. Med. 49:296–305

    Article  PubMed  CAS  Google Scholar 

  • Berk, P., and Blaschke, T. (1972) Detection of Gilbert’s syndrome in patients with hemolysis. Ann. Inter. Med. 77:527–540

    CAS  Google Scholar 

  • Berk, P., Wolkoff, A., and Berlin, N. (1975) Inborn errors of bilirubin metabolism. Med. Clin. North Am. 59(4):803–816

    PubMed  CAS  Google Scholar 

  • Blaschke, T., et al. (1974) Crigler–Najjar syndrome: an unusual case with development of nerve damage at age 18. Ped. Res. 8:573–590

    Article  CAS  Google Scholar 

  • Bloomer, J., et al. (1971) Studies on the mechanism of fasting hyperbilirubinemia. Gastroent. 61:479–486

    CAS  Google Scholar 

  • Delage, Y., et al. (1977) Rotor’s syndrome: evidence for an impairment of hepatic uptake and storage of cholephilic organic anions. Digestion 15:228–234

    Google Scholar 

  • Felsher, B., et al. (1973) Hepatic bilirubin glucuronidation in Gilbert’s syndrome. J. Lab. Clin. Med. 81:829–836

    PubMed  CAS  Google Scholar 

  • Fevery, J., et al. (1977) Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert’s syndrome and Crigler-Najjar disease. J. Clin. Invest. 60:970–982

    Article  PubMed  CAS  Google Scholar 

  • Goresky, C., et al. (1978) Definition of a conjugation dysfunction in Gilbert’s syndrome. Clin. Sci. Mol. Med. 55:63–69

    PubMed  CAS  Google Scholar 

  • Ostrow, J. (1986) Bile pigments and jaundice. Ostrow, J., ed. Marcell Dekker, New York, NY

    Google Scholar 

  • Owens, D., and Sherlock, S. (1973) Diagnosis of Gilbert’s syndrome: role of reduced caloric test. BMJ 3:559–567

    Article  PubMed  CAS  Google Scholar 

  • Powell, L., et al. (1967) The assessment of red cell survival in idiopathic unconjugated hyperbiliruinemia (Gilbert’s syndrome) by the use of radioactive diisopropylfluorophosphate. Aust. Ann. Med. 16:221–232

    PubMed  CAS  Google Scholar 

  • Reyes, H., et al. (1969) Organic anion-binding protein in rat liver: drug induction and its physiologic consequence. Proc. Natl. Acad. Sci. 64:168–173

    Article  PubMed  CAS  Google Scholar 

  • Schoenfield, L., et al. (1963) Studies of chronic idiopathic jaundice (Dubin-Johnson syndrome) Gastroent. 44:101–108

    CAS  Google Scholar 

  • Weiss, J., et al. (1983) Albumin binding and hyperbilirubinemia. N. Engl. J. Med. 309:147–150

    Article  PubMed  CAS  Google Scholar 

  • WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50

    Google Scholar 

  • Gilbert, A. (1907) Les trois cholemies congenitales. Bull. Mem. Soc. Med. Hop. Paris. 24:1203–1208

    Google Scholar 

  • Arias, I., et al. (1969) Chronic non hemolytic unconjugated hyperbilirubinemia with glucuronyl trandferase deficiency. Am. J. Med. 47:395–404

    Article  PubMed  CAS  Google Scholar 

  • Black, M., and Billing, B. (1969) Hepatic bilirubin UDP glucuronyl transferase activity in liver disease and Gilberts syndrome. N. Engl. J. Med. 280:1266–1271

    Article  PubMed  CAS  Google Scholar 

  • Black, M., and Billing, B. (1971) Hepatic bilirubin glucuronyl transferase in liver disease and Gilbert’s syndrome. N. Engl. J. Med. 280:1266–1272

    Article  Google Scholar 

  • Okolicsany, L., et al. (1978) An evaluation of bilirubin kinetics with respect to the diagnosis of Gilbert’s syndrome. Clin. Sci. Mol. Med. 54:539–547

    Google Scholar 

  • Jezequel, A., et al. (1980) In Familial hyperbilirubinemia. Okolicsanyi, L. ed., Wiley, New York, NY, P. 69

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology & Anatomy, Rosalind Franklin University of Medicine & Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL, 60064, USA

    David W. McCandless

Authors
  1. David W. McCandless
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David W. McCandless .

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

McCandless, D.W. (2011). Kernicterus in Older Children and Adults. In: Kernicterus. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4419-6555-4_19

Download citation

Publish with us

Policies and ethics

Search

Navigation