Kernicterus pp 203-208 | Cite as

Kernicterus in Older Children and Adults

Part of the Contemporary Clinical Neuroscience book series (CCNE)


Kernicterus represents a metabolic encephalopathy afflicting newborns and children with unconjugated hyperbilirubinemia. Also occurring are several types of hyperbilirubinemia with both unconjugated and conjugated present in the serum.


Bilirubin Level Unconjugated Bilirubin Glucuronyl Transferase Unconjugated Hyperbilirubinemia Bilirubin Conjugate 
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  1. Auclair, C., et al. (1976) Bilirubin and paranitrophenol glucuronyl transferase activities and ultrastructural aspect of the liver in patients with chronic hemolytic anemias. Biomedicine 25:61–72PubMedGoogle Scholar
  2. Berk, P. (1970) Constitutional hepatic dysfunction (Gilbert’s syndrome) Am. J. Med. 49:296–305PubMedCrossRefGoogle Scholar
  3. Berk, P., and Blaschke, T. (1972) Detection of Gilbert’s syndrome in patients with hemolysis. Ann. Inter. Med. 77:527–540Google Scholar
  4. Berk, P., Wolkoff, A., and Berlin, N. (1975) Inborn errors of bilirubin metabolism. Med. Clin. North Am. 59(4):803–816PubMedGoogle Scholar
  5. Blaschke, T., et al. (1974) Crigler–Najjar syndrome: an unusual case with development of nerve damage at age 18. Ped. Res. 8:573–590CrossRefGoogle Scholar
  6. Bloomer, J., et al. (1971) Studies on the mechanism of fasting hyperbilirubinemia. Gastroent. 61:479–486Google Scholar
  7. Delage, Y., et al. (1977) Rotor’s syndrome: evidence for an impairment of hepatic uptake and storage of cholephilic organic anions. Digestion 15:228–234Google Scholar
  8. Felsher, B., et al. (1973) Hepatic bilirubin glucuronidation in Gilbert’s syndrome. J. Lab. Clin. Med. 81:829–836PubMedGoogle Scholar
  9. Fevery, J., et al. (1977) Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert’s syndrome and Crigler-Najjar disease. J. Clin. Invest. 60:970–982PubMedCrossRefGoogle Scholar
  10. Goresky, C., et al. (1978) Definition of a conjugation dysfunction in Gilbert’s syndrome. Clin. Sci. Mol. Med. 55:63–69PubMedGoogle Scholar
  11. Ostrow, J. (1986) Bile pigments and jaundice. Ostrow, J., ed. Marcell Dekker, New York, NYGoogle Scholar
  12. Owens, D., and Sherlock, S. (1973) Diagnosis of Gilbert’s syndrome: role of reduced caloric test. BMJ 3:559–567PubMedCrossRefGoogle Scholar
  13. Powell, L., et al. (1967) The assessment of red cell survival in idiopathic unconjugated hyperbiliruinemia (Gilbert’s syndrome) by the use of radioactive diisopropylfluorophosphate. Aust. Ann. Med. 16:221–232PubMedGoogle Scholar
  14. Reyes, H., et al. (1969) Organic anion-binding protein in rat liver: drug induction and its physiologic consequence. Proc. Natl. Acad. Sci. 64:168–173PubMedCrossRefGoogle Scholar
  15. Schoenfield, L., et al. (1963) Studies of chronic idiopathic jaundice (Dubin-Johnson syndrome) Gastroent. 44:101–108Google Scholar
  16. Weiss, J., et al. (1983) Albumin binding and hyperbilirubinemia. N. Engl. J. Med. 309:147–150PubMedCrossRefGoogle Scholar
  17. WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50Google Scholar
  18. Gilbert, A. (1907) Les trois cholemies congenitales. Bull. Mem. Soc. Med. Hop. Paris. 24:1203–1208Google Scholar
  19. Arias, I., et al. (1969) Chronic non hemolytic unconjugated hyperbilirubinemia with glucuronyl trandferase deficiency. Am. J. Med. 47:395–404PubMedCrossRefGoogle Scholar
  20. Black, M., and Billing, B. (1969) Hepatic bilirubin UDP glucuronyl transferase activity in liver disease and Gilberts syndrome. N. Engl. J. Med. 280:1266–1271PubMedCrossRefGoogle Scholar
  21. Black, M., and Billing, B. (1971) Hepatic bilirubin glucuronyl transferase in liver disease and Gilbert’s syndrome. N. Engl. J. Med. 280:1266–1272CrossRefGoogle Scholar
  22. Okolicsany, L., et al. (1978) An evaluation of bilirubin kinetics with respect to the diagnosis of Gilbert’s syndrome. Clin. Sci. Mol. Med. 54:539–547Google Scholar
  23. Jezequel, A., et al. (1980) In Familial hyperbilirubinemia. Okolicsanyi, L. ed., Wiley, New York, NY, P. 69Google Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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