Many other metabolic disturbances have been described besides those involving energy metabolism as described in the preceding chapter. For example (Youngs, J., and Cornatzer, W. 1963), the effects of bilirubin on mitochondrial phospholipids in rat liver have been comparatively studied. Bilirubin, arsenate, dinitrophenol, and oligomycin were all evaluated and compared as regards their ability to alter phospholopid synthesis in rat liver mitochondria. Results showed that bilirubin, arsenate, and oligomycin inhibited synthesis of lecithin, phosphatidyl serine, and phosphatidyl ethanoamine. Dinitrophenol, in addition to the phospholipids above, also inhibited sphingomyelin and phosphatidyl inositol.
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