Kernicterus pp 109-114 | Cite as

Jaundice and Other Biochemical Changes

  • David W. McCandless
Part of the Contemporary Clinical Neuroscience book series (CCNE)


Many other metabolic disturbances have been described besides those involving energy metabolism as described in the preceding chapter. For example (Youngs, J., and Cornatzer, W. 1963), the effects of bilirubin on mitochondrial phospholipids in rat liver have been comparatively studied. Bilirubin, arsenate, dinitrophenol, and oligomycin were all evaluated and compared as regards their ability to alter phospholopid synthesis in rat liver mitochondria. Results showed that bilirubin, arsenate, and oligomycin inhibited synthesis of lecithin, phosphatidyl serine, and phosphatidyl ethanoamine. Dinitrophenol, in addition to the phospholipids above, also inhibited sphingomyelin and phosphatidyl inositol.


Bilirubin Concentration Unconjugated Bilirubin Mitochondrial Phospholipid Unconjugated Hyperbilirubinemia Cytochrome P450 Oxidase 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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