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Kernicterus pp 109-114 | Cite as

Jaundice and Other Biochemical Changes

  • David W. McCandless
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Many other metabolic disturbances have been described besides those involving energy metabolism as described in the preceding chapter. For example (Youngs, J., and Cornatzer, W. 1963), the effects of bilirubin on mitochondrial phospholipids in rat liver have been comparatively studied. Bilirubin, arsenate, dinitrophenol, and oligomycin were all evaluated and compared as regards their ability to alter phospholopid synthesis in rat liver mitochondria. Results showed that bilirubin, arsenate, and oligomycin inhibited synthesis of lecithin, phosphatidyl serine, and phosphatidyl ethanoamine. Dinitrophenol, in addition to the phospholipids above, also inhibited sphingomyelin and phosphatidyl inositol.

Keywords

Bilirubin Concentration Unconjugated Bilirubin Mitochondrial Phospholipid Unconjugated Hyperbilirubinemia Cytochrome P450 Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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