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Further Insight into Cognitive and Metacognitive Processes of the Tip-of-the-Tongue State with an Amnesic Drug as Cognitive Tool

  • Elisabeth Bacon
Chapter

Abstract

The tip-of-the-tongue (TOT) state may be viewed as temporary and reversible micro-amnesia. Amnesic drugs, such as benzodiazepines, may be used as tools to reveal functional principles of normal cognitive processes. We investigated the effects of lorazepam on TOT state. With general information questions, Lorazepam participants provided more commission errors and more TOT states following commissions than placebo participants, whereas the resolution of the TOTs was unimpaired. The higher amount of incorrect recalls provided by lorazepam participants may partially result from the fact that they are more frequently in a state of transitory inaccessibility of a known item, identifiable as a commission TOT (participants provide a persistent alternate and experience the phenomenological TOT only after having been informed of the error). This way of resolving the TOT conflict is discussed in light of the anxiolytic effect of the drug. Lorazepam led the participants to generate more persistent alternates when in a TOT while preserving the cognitive process of TOT, that is, the temporary failure to retrieve a known word.

Keywords

Semantic Memory Commission Error Confidence Judgment Retrieval Failure General Knowledge Question 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by Inserm and by a Cognitique “Impairments and recovery of cognitive functions” grant from the French Ministry of Research. The author wishes to thank Marie Izaute, Bennett Schwartz, and Laurence Paire-Ficout for their valuable contribution to the TOT study.

References

  1. Allen, D., Curran, H. V., & Lader, M. (1993). The effects of single doses of CL 284, 846, lorazepam, and placebo on psychomotor and memory function in normal male volunteers. European Journal Clinical Pharmacology, 45, 313–320.Google Scholar
  2. Bacon, E., Danion, J. M., Kauffman-Muller, F., Schelstraete, M. A., Bruant, A., Sellal, F., & Grange, D. (1998). Confidence level and feeling of knowing for episodic and semantic memory: An investigation of lorazepam effects on metamemory. Psychopharmacology, 138, 318–325.CrossRefGoogle Scholar
  3. Bacon E., Schwartz B., Paire-FicoutM., & Izaute M. (2007). Dissociation between the cognitive process and the phenomenological experience of TOT: Effect of the anxiolytic drug lorazepam on TOT states. Conscious Cognition, 16, 360–373.CrossRefGoogle Scholar
  4. Bäckman L., Lipinska B. (1993). Monitoring of general knowledge: Evidence for preservation in early Alzheimer’s disease (1993). Neuropsychologia, 31, 335–345.CrossRefGoogle Scholar
  5. Barker, M. J., Greenwood, K. M., Jackson, M., & Crowe, S. F. (2004). Cognitive effects of long-term benzodiazepine use: A meta-analysis. CNS Drugs, 18, 37–48.CrossRefGoogle Scholar
  6. Beracochea, D. (2006). Anterograde and retrograde effects of benzodiazepines on memory. ScientificWorld Journal, 16, 1460–1465.CrossRefGoogle Scholar
  7. Biedermann, B., Ruh, N., Nickels, L., & Coltheart, M. (2008). Information retrieval in tip of the tongue states: New data and methodological advances. Journal of Psycholinguist Research, 37, 171–198.CrossRefGoogle Scholar
  8. Brennen, T., Vikan, A., & Dybdahl, R. (2007). Are tip-of-the-tongue states universal? Evidence from the speakers of an unwritten language. Memory, 15, 167–176.CrossRefGoogle Scholar
  9. Brown, A. S. (1991). A review of the tip-of-the-tongue experience. Psychological Bulletin,109, 204–223.CrossRefGoogle Scholar
  10. Brown, J., Brown, M. W., & Bowes, J. B. (1983). Effects of lorazepam on rate of forgetting, on retrieval from semantic memory and dexterity. Neuropsychologia, 21, 501–512.CrossRefGoogle Scholar
  11. Brown, R., & McNeill D. (1966). The tip of the tongue experience. Psychological Bulletin, 1090, 339–347.Google Scholar
  12. Burke, D. M., MacKay, D. G., Worthley, J. S., & Wade, E. (1991). On the tip of the tongue: What causes word finding failures in young and older adults? Journal of Memory and Language, 30, 542–579.CrossRefGoogle Scholar
  13. Curran, H. V. (1991). Benzodiazepines, memory and mood: A review. Psychopharmacology, 105, 1–8.CrossRefGoogle Scholar
  14. Curran, H. V. (1999). Effects of anxiolytics on memory. Human Psychopharmacology, 14, 72–79.CrossRefGoogle Scholar
  15. Danion, J. M. (1994). Drugs as tools for investigating memory. European Neuropsycho-pharmacology, 4, 179–180.CrossRefGoogle Scholar
  16. Duka, T., Curran, H. V., Rusted, J. M., & Weingartner, H. J. (1996). Perspectives on cognitive psychopharmacology research. Behavioral Pharmacology, 7, 401–410.CrossRefGoogle Scholar
  17. Erickson, T. D., & Mattson, M. E. (1981). From word to meaning: A semantic illusion. Journal of Verbal Learning and Verbal Behaviour, 20, 540–551.CrossRefGoogle Scholar
  18. File, S. E., Sharma, R., & Shaffer, J. (1992). Is lorazepam-induced amnesia specific to the type of memory or to the task used to assess it? Journal of Psychopharmacology, 61, 76–80.CrossRefGoogle Scholar
  19. Flor, H. (2002). Phantom-limb pain: Characteristics, causes, and treatment. Lancet Neurology, 3, 182–189.CrossRefGoogle Scholar
  20. Fluck, E., File, S. E., Springett, J., Kopelman, M. D., Rees, J., & Orgill, J. (1998). Does the sedation resulting from sleep deprivation and lorazepam cause similar cognitive deficits? Pharmacology Biochemistry Behavior, 59, 909–915.CrossRefGoogle Scholar
  21. Giersch, A., Boucart, M., Elliott, M., & Vidailhet, P. (2010). Atypical behavioural effects of lorazepam: Clues to the design of novel therapies? Pharmacology and therapeutics, 126(1), 94–108.CrossRefGoogle Scholar
  22. Green, J. F., McElholm, A., & King, D. J. (1996). A comparison of the sedative and amnestic effects of chlorpromazine and lorazepam. Psychopharmacology, 128, 67–73.CrossRefGoogle Scholar
  23. Harley, T. A., & Bown, H. E. (1998). What causes a tip-of-the-tongue state? Evidence for lexical neighbourhood effects in speech production. British Journal of Psychology, 89, 151–174.CrossRefGoogle Scholar
  24. Hart, J. T. (1965). Memory and the feeling-of-knowing experience. Journal of Education and Psychology, 56, 208–216.CrossRefGoogle Scholar
  25. Harvey, S. C. (1980). Hypnotics and sedatives. In A. Goodman Gilman, L. S. Goodman, & A. Gilman (Eds.), The pharmacological basis of therapeutics (pp. 339–375). New York: Macmillan.Google Scholar
  26. Izaute, M., & Bacon, E. (2005). Specific effects of an amnesic drug: Effect of lorazepam on study time allocation and on judgment of learning. Neuropsychopharmacology, 30, 196–204.CrossRefGoogle Scholar
  27. Izaute, M., Paire-Ficout, L., & Bacon, E. (2004). Benzodiazepines and semantic memory: Effects of lorazepam on the Moses illusion. Psychopharmacology, 172, 309–315.CrossRefGoogle Scholar
  28. Janowsky, J. S., Shimamura, A. P., & Squire, L. R. (1989a). Memory and metamemory: Comparisons between patients with frontal lobe lesions and amnesic patients. Psychobiology 17, 3–11.Google Scholar
  29. Janowsky, J. S., Shimamura, A. P, & Squire, L. R. (1989b). Source memory impairment in patients with frontal lobe lesions. Neuropsychologia, 27, 1043–1056.CrossRefGoogle Scholar
  30. Jones, G. V., & Langford, S. (1987). Phonological blocking in the tip-of-the tongue state. Cognition, 26, 115–22.CrossRefGoogle Scholar
  31. Kleven, M. S., & Koek, W. (1999). Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans. Psychopharmacology, 141, 206–212.CrossRefGoogle Scholar
  32. Koriat, A. (1993). How do we know that we know? The accessibility model of the feeling of knowing. Psychological Review, 100, 609–639.CrossRefGoogle Scholar
  33. Koriat, A. (1995). Dissociating knowing and the feeling of knowing: Further Evidence for the Accessibility Model. Journal of Experimental Psychology: General, 124, 311–333.CrossRefGoogle Scholar
  34. Koriat, A. (1998). Illusions of knowing: The link between knowledge and metaknowledge. In V. Y. Yzerbyt, G. Lories, & B. Dardenne (Eds.), Metacognition: Cognitive and social dimensions (pp. 16–34). London: SAGE.Google Scholar
  35. Koriat, A., & Goldsmith, M. (1996). Memory in naturalistic and laboratory contexts: Distinguish the accuracy-oriented and quantity-oriented approaches to memory assessment. Journal of Experimental Psychology: General, 123, 297–315.CrossRefGoogle Scholar
  36. Maril, A., Simons, J. S., Weaver, J. J., & Schacter, D. L. (2005). Graded recall success: An event-related fMRI comparison of tip of the tongue and feeling of knowing. NeuroImage, 24, 1130–1138.CrossRefGoogle Scholar
  37. Massin-Krauss, M., Bacon, E., & Danion, J. M. (2002). Effects of the benzodiazepine lorazepam on monitoring and control processes in semantic memory. Consciousness and Cognition, 11, 123–137.CrossRefGoogle Scholar
  38. Matison, R., Mayeux, R., Rosen, J., & Fahn, S. (1982). “Tip-of-the-tongue” phenomenon in Parkinson disease. Neurology, 32, 567–570.CrossRefGoogle Scholar
  39. Melzack, R., Coderre, T. J., Katz, J., & Vaccarino, A. L. (2001). Central neuroplasticity and pathological pain. Annual reports of New York Academy of Sciences, 933, 157–174.CrossRefGoogle Scholar
  40. Mintzer, M., Kleykamp, B., & Griffiths, R. (2010). Dose effects of triazolam and scopolamine on metamemory. Experimental and Clinical Psychopharmacology, 18(1), 17–31CrossRefGoogle Scholar
  41. Miozzo, M., & Caramazza, A. (1997). Retrieval of lexical-syntactic features in tip-of-the-tongue states. Journal of Experimental Psychology: Learning, Memory, and Cognition, 23, 1410–1423.CrossRefGoogle Scholar
  42. Nelson, T. O. (1984). A comparison of current measures of the accuracy of feeling-of-knowing predictions. Psychological Bulletin, 95, 109–133.CrossRefGoogle Scholar
  43. Nelson, T. O., McSpadden, M., Fromme, K., & Marlatt, G. A. (1986). Effects of alcohol intoxication on metamemory and on retrieval from long-term memory. Journal of Experimental Psychology: General, 115, 247–254.CrossRefGoogle Scholar
  44. Nelson, T. O., & Narens, L. (1994). Why investigate metacognition? In J. Metcalfe & A. Shimamura (Eds.), Metacognition: Knowing about knowing (pp. 1–25). Cambridge, MA: MIT Press.Google Scholar
  45. Norris, H. (1971). The action of sedatives on brain stem occulomotor system in man. Neuropharmacology, 10, 181–191.CrossRefGoogle Scholar
  46. Pappas, B. A., Sunderland T., Weingartner, H. M., Vitiello, B., Martinson, H., & Putnam, K. (1992). Alzheimer’s disease and feeling-of-knowing for knowledge and episodic memory. The Journal of Gerontology. Series B: Psychological Sciences, 47, 159–164.Google Scholar
  47. Reason, J., & Lucas, D. (1984). Using cognitive diaries to investigate naturally occuring memory blocks. In J. E. Harris & P. E. Morris (Eds.), Everyday memory, actions, and absentmindedness (pp. 53–70). London: Academic.Google Scholar
  48. Reder, L. M., & Kusbit, G. W. (1991). Locus of the Moses illusion: Imperfect encoding, retrieval, or match? Journal of Memory and Language, 30, 385–406.CrossRefGoogle Scholar
  49. Schacter, D. L. (1999). The seeven sins of memory. Insight from psychology and cognitive neuroscience. American Psychologist, 54, 182–203.Google Scholar
  50. Schwartz, B. L. (1998). Illusory tip-of-the-tongue states. Memory, 6, 623–642.CrossRefGoogle Scholar
  51. Schwartz, B. L. (1999). Sparkling at the end of the tongue: The etiology of tip-of-the-tongue phenomenology. Psychonomic Bulletin Review, 6, 379–93.CrossRefGoogle Scholar
  52. Schwartz, B. L. (2001). The relation of tip-of-the-tongue states and retrieval time. Memory and Cognition, 229, 117–126.Google Scholar
  53. Schwartz, B. L. (2002a). The phenomenology of naturally-occurring tip-of-the-tongue states: A diary study. In S. P. Shohov (Ed.), Advances in Psychology Research (Vol. 8, pp. 71–84). New York: Nova Sciences.Google Scholar
  54. Schwartz, B. L. (2002b). Tip-of-the-tongue states. Phenomenology, mechanism, and lexical retrieval. Mahwah, NJ: Erlbaum.Google Scholar
  55. Schwartz, B. L. (2008). Working memory load differentially affects tip-of-the-tongue states and feeling-of-knowing judgments. Memory Cognition, 36, 9–19.CrossRefGoogle Scholar
  56. Schwartz, B. L., & Smith, S. M. (1997). The retrieval of related information influences tip-of-the-tongue states. Journal of Memory and Language, 36, 68–86.CrossRefGoogle Scholar
  57. Schwartz, B. L., Travis, D. M., Castro, A. M., & Smith, M. S. (2000). The phenomenology of real and illusory tip-of-the-tongue states. Memory and Cognition, 28, 18–27.CrossRefGoogle Scholar
  58. Shimamura, A. P., & Squire, L. R. (1986). Memory and metamemory: A study of the feeling-of-knowing phenomenon in amnesic patients. Journal of Experimental Psychology: Learning, Memory, and Cognition, 12, 452–460.CrossRefGoogle Scholar
  59. Shimamura, A. P., & Squire, L. R. (1988). Long-term memory in amnesia: Cued recall, recognition memory, and confidence ratings. Journal of Experimental Psychology: Learning, Memory, and Cognition, 14, 763–770.CrossRefGoogle Scholar
  60. Shimamura, A. P. (1994). The neuropsychology of metacognition. In: J. Metcalfe & A. P. Shimamura (Eds.), Metacognition: Knowing about knowing (pp. 253–276). Cambridge, MA: MIT Press.Google Scholar
  61. Smith, S. M. (1994). Frustrated feelings of imminent recall: On the tip-of-the tongue. In J. Metcalfe & A. P. Shimamura (Eds.), Metacognition: Knowing about knowing (pp. 27–46). Cambridge, MA: MIT Press.Google Scholar
  62. Stewart, S. A. (2005). The effects of benzodiazepines on cognition. Journal Clinical Psychiatry, 66, 9–13.Google Scholar
  63. Taylor, J. K., & MacKay, D. G. (2003). Tip-of-the-tongue phenomena: Goldmine or can of worms. Review of Tip-of-the-tongue states: Phenomenology, mechanism, and lexical retrieval. American Journal of Psychology, 116, 291–298.CrossRefGoogle Scholar
  64. Vanover, K.E., Robledo, S., Huber, M., & Carter, R. B. (1999). Pharmacological evaluation of a modified conflict procedure: Punished drinking in non-water-deprived rats. Psychopharmacology, 145, 333–341.CrossRefGoogle Scholar
  65. Vermeeren, A., Jackson, J. L., Muntjewerff, N. D., Quint, P. J,. Harrison, E. M., & O’Hanlon, J. F. (1995). Comparison of acute alprazolam (0.25, 0.50 and 1.0 mg) effects versus those of lorazepam 2 mg and placebo on memory in healthy volunteers using laboratory and telephone tests. Psychopharmacology, 118, 1–9.CrossRefGoogle Scholar
  66. Vigliocco, G., Antonini, T., & Garrett, M. F. (1997). Grammatical gender is on the tip of Italian tongues. Psychological Science, 8, 314–317.CrossRefGoogle Scholar
  67. Wechsler, D. (1987). Wechsler memory scale – Revised manual. San Antonio, TX: Psychological Corporation.Google Scholar
  68. Widner, R. L., Smith, S. M., & Graziano, W. G. (1996). The effects of demand characteristics on the reporting of tip-of-the-tongue states and feeling-of-knowing states. American Journal of Psychology, 109, 525–538.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Psychiatry DepartmentNational Institute for Health and Medical Research (U 666 INSERM) and University HospitalStrasbourg CedexFrance

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