The Sclera pp 137-171 | Cite as

Pathology in Scleritis

  • Maite Sainz de la MazaEmail author
  • Joseph Tauber
  • C. Stephen Foster


Histopathologically, most cases of episcleritis and diffuse or nodular scleritis show chronic, nongranulomatous inflammation with lymphocytes and plasma cells, vascular dilatation, and edema. By contrast, most cases of necrotizing scleritis show chronic granulomatous inflammation with epithelioid cells, multinucleated giant cells, lymphocytes, plasma cells, and less often neutrophils, along with inflammatory microangiopathy. Mast cells and eosinophils can sometimes be seen in the granuloma and around vessels.

In infectious scleritis, stainings and cultures of scleral scrapings may demonstrate the microorganism implicated. However, when scrapings are negative, analysis of conjunctival and scleral specimens by histopathology (stainings and cultures), tissue homogenization (PCR, culture, or cell culture lines), and indirect immunofluorescence (antimicrobe antibodies) techniques may be important for microbe isolation.


Herpes Simplex Virus Type Multinucleated Giant Cell Epithelioid Cell Fibrinoid Necrosis Necrotizing Vasculitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Maite Sainz de la Maza
    • 1
    Email author
  • Joseph Tauber
    • 2
  • C. Stephen Foster
    • 3
  1. 1.Clinical Institute of OphthalmologyHospital Clinic of BarcelonaBarcelonaSpain
  2. 2.Tauber Eye CenterKansas CityUSA
  3. 3.Massachusetts Eye Research and Surgery InstitutionCambridgeUSA

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