Cytopathology of Myxoid Soft Tissue Lesions

  • Walid E. Khalbuss
  • Anil V. Parwani
Part of the Essentials in Cytopathology book series (EICP, volume 9)


Myxoid soft tissue lesions are a group of lesions that are ­distinguished by their unique and consistent ability to produce an overwhelming abundance of myxoid ground substance along with the proliferating cells that constitute the lesion. The myxoid material is composed of sulfated and nonsulfated glycosaminoglycans. It appears on H&E sections as a thin amorphous semitransparent or grey substance. Special stains such as alcian blue can confirm its presence and only sulfated glycosaminoglycans (chondroid substance) will be positive after treatment by hyaluronidase.


Ancillary Study Myxoid Liposarcoma Nodular Fasciitis Spindle Cell Lipoma Myxoid Change 
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Copyright information

© Springer US 2011

Authors and Affiliations

  • Walid E. Khalbuss
    • 1
  • Anil V. Parwani
    • 1
  1. 1.Shadyside HospitalUniversity of Pittsburgh Medical CenterPittsburghUSA

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