Cytopathology of Spindle Cell Lesions of Soft Tissue and Bone

  • Walid E. Khalbuss
  • Anil V. Parwani
Part of the Essentials in Cytopathology book series (EICP, volume 9)


Spindle cell lesions of soft tissue and bone encompass a wide ­spectrum of benign and malignant conditions. They include ­reactive lesions such as granulomatous inflammation, pseudosarcomas such as nodular fasciitis, benign mesenchymal tumors such as neuro­fibroma and schwannoma, low and high-grade sarcomas, spindle cell carcinoma, and spindle cell melanoma. The sarcomas that can be presented as spindle cells include fibrosarcoma (FS), leiomyosarcoma (LMS), synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), Kaposi sarcoma, low-grade fibromyxoid sarcoma, gastrointestinal stromal tumor (GIST), and some ­angiosarcomas1,2 (Table 3.1).


Spindle Cell Synovial Sarcoma Malignant Peripheral Nerve Sheath Tumor Solitary Fibrous Tumor Ancillary Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer US 2011

Authors and Affiliations

  • Walid E. Khalbuss
    • 1
  • Anil V. Parwani
    • 1
  1. 1.Shadyside HospitalUniversity of Pittsburgh Medical CenterPittsburghUSA

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