The Role of Inflammation in the Generation and Maintenance of Memory T Cells

  • Noah S. Butler
  • John T. Harty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 684)


Following infection or vaccination, antigen-specific T cells undergo enormous expansion in numbers and differentiate into effector cells that control infection and modulate other aspects of innate and adaptive immunity. The effector T-cell expansion phase is followed by an abrupt period of contraction, during which 90–95% of antigen-specific T cells are eliminated. The surviving pool of T cells subsequently differentiates into long-lived memory populations that can persist for the life of the host and mediate enhanced protective immunity following pathogen re-infection. The generation and maintenance of memory T-cell populations are influenced by a multitude of factors, including inflammatory cytokines that can act on T cells at various points during their differentiation. Herein, we discuss our current understanding of how inflammation shapes not only the quantity and quality of memory T cells, but also the rate at which functional memory T-cell populations develop.


Contraction Phase LCMV Infection Listeria Monocytogenes Infection Proliferative Expansion Follow LCMV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science +Business Media 2010

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity of IowaIowa CityUSA

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