Transcriptional Regulation during CD8 T-Cell Immune Responses

  • Ivana Munitic
  • César Evaristo
  • Hsueh Cheng Sung
  • Benedita Rocha
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 684)


Naïve CD8 T cells differentiate in response to antigen stimulation. They acquire the capacity to express multiple effector molecules and mediate effector functions that contribute to infection control. Once antigen loads are reduced they revert progressively to a less activated status and eventually reach a steady-state referred to as “memory” that is very different from that of naïve cells. Indeed, these “memory” cells are “ready-to-go” populations that acquired the capacity to respond more efficiently to antigen stimulation. They modify their cell cycle machinery in order to divide faster; they likely improve DNA repair and other cell survival mechanisms in order to survive during division and thus to generate much larger clones of effector cells; finally, they also mediate effector functions much faster. 1These modifications are the consequence of changes in the expression of multiple genes i.e., on the utilization of a new transcription program.


Memory Cell Kill Target Cell Transcription Apparatus Tumor Necrosis Factor Alpha Gene NFAT Protein 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Ivana Munitic
    • 1
  • César Evaristo
    • 1
  • Hsueh Cheng Sung
    • 1
  • Benedita Rocha
    • 1
  1. 1.Faculté de Médecine René Descartes Paris 5INSERM, U591ParisFrance

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