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Memory T Cells pp 189-197 | Cite as

Memory T-Cell Homeostasis and Senescence during Aging

  • Sian M. Henson
  • Arne N. Akbar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 684)

Abstract

Evidence is accumulating that old individuals are more susceptible to infection with organisms to which they were previously immune, indicating that there might be a limit to the persistence of immune memory. The prevailing concept is that defects in memory T-cell populations result from inexorable end-stage differentiation as a result of repeated lifelong antigenic challenge. We discuss here mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.

Keywords

Telomere Length Replicative Senescence Telomere Erosion hTERT Protein Immune Risk Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Division of Infection and Immunity, Department of ImmunologyUniversity College LondonLondonUK

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