Clinical Features

  • Timothy B. Gardner
  • Chris E. Forsmark


Increasingly, the clinical spectrum of autoimmune pancreatitis has been found to be quite variable. While the classic description of an elderly male with painless jaundice is still valid, further study has revealed a wide variety of clinical presentations. This is most likely due to the refined understanding of the two variants of autoimmune pancreatitis—lymphoplasmacytic sclerosing pancreatitis (LPSP—type 1) and idiopathic duct-centric chronic pancreatitis (IDCP) or AIP with granulocytic epithelial lesions (GELs—type 2). These two entities have distinct clinical profiles. This chapter focuses on the prevalence, natural history, and demographic features of autoimmune pancreatitis. Serologic and clinical features are reviewed. Finally, means by which to distinguish autoimmune pancreatitis from malignancy are highlighted. Eventually, with more robust experience with the two AIP subtypes, refinement of the clinical spectrum will allow for more optimal treatment recommendations in this disease.


Acute Pancreatitis Chronic Pancreatitis Celiac Disease Obstructive Jaundice Autoimmune Pancreatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Gastroenterology and HepatologyDartmouth Medical SchoolLebanonUSA
  2. 2.Division of Gastroenterology, Hepatology, and NutritionUniversity of FloridaGainesvilleUSA

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