British Experience

  • Evangelos Kalaitzakis
  • Robert Sutton
  • George Webster


Case reports over the last 30 years from Britain have been related to autoimmune pancreatitis (AIP) and/or (IgG4-SC), but the first series of patients was published in 2007, adding to the body of evidence that it is a global disease. Following the introduction of generally accepted terminology and the recognition that they both constitute manifestations of a multiorgan disorder, AIP and IgG4-SC have been increasingly diagnosed in the UK. As in other parts of the world, AIP is usually diagnosed in middle-aged males, who present with obstructive jaundice. With the clinical presentation of AIP/IgG4-SC often mimicking pancreaticobiliary malignancy and the recent centralization of pancreatic cancer services in the UK, it is likely that the diagnosis and management of AIP/IgG4-SC will be enhanced within specialized hepatopancreaticobiliary centers. Although IgG4-SC can occur in patients without AIP, 71 % of patients with AIP in the UK are also diagnosed with extrapancreatic biliary involvement. Despite the lack of prospective randomized placebo-controlled data related to steroid use in AIP/IgG4-SC, oral prednisolone is commonly used to induce remission but also to treat relapse. Azathioprine appears to have a role in maintaining remission in patients who relapse after a course of steroids.


Pancreatic Cancer Obstructive Jaundice Sclerosing Cholangitis Serum IgG4 Level Lymphoplasmacytic Infiltrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Autoimmune pancreatitis


IgG4-related sclerosing cholangitis


National Health Service


University College Hospital


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Evangelos Kalaitzakis
    • 1
  • Robert Sutton
    • 2
  • George Webster
    • 3
  1. 1.Department of GastroenterologySkåne University HospitalLundSweden
  2. 2.NIHR Pancreas Biomedical Research UnitRoyal Liverpool University HospitalLiverpoolUK
  3. 3.GI ServicesUniversity College London HospitalsLondonUK

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