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The Elderly as a Sensitive Population in Environmental Exposures: Making the Case

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Reviews of Environmental Contamination and Toxicology Volume 207

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 207))

Abstract

The population of the United States is aging. A demographic shift of the average age in the United States is occurring rapidly and unavoidably. According to estimates, 20% of all Americans will be 65 or older by the year 2030 (CDC 2004), which is a serious concern for physicians and medical science (Geokas et al. 1990). Further, the average 75-year-old has three chronic medical conditions and uses five prescription drugs (CDC 2004; Qato et al. 2008). It is now recognized that infants and small children are not just miniature adults. Children have many unique anatomic, developmental, physiologic, immunologic, and psychological considerations (Milla 2002; WHO 2005; Williams et al. 2006). They have special nutritional and medical needs because of the immature state of their physiological and anatomical development. Similarly, the elderly are not just older adults with the same needs as healthy young adults. The US Centers for Disease Control and Prevention (CDC) recognizes this difference and states that older adults have unique challenges and different medical needs than younger adults (CDC 2004).

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References

  • Abate N, Haffner SM, Garg A, Peshock RM, Grundy SM (2002) Sex steroid hormones, upper body obesity, and insulin resistance. J Clin Endocrinol Metab 87(10):4522–4527

    Article  CAS  Google Scholar 

  • Abe O, Yamasue H, Aoki S, Suga M, Yamada H, Kasai K, Masutani Y, Kato N, Kato N, Ohtomo K (2008) Aging in the CNS: comparison of gray/white matter volume and diffusion tensor data. Neurobiol Aging 29:102–116

    Article  Google Scholar 

  • Abou-Donia MB, Wilmarth KR, Abdel-Rahman AA, Jensen KF, Oehme FW, Kurt TL (1996) Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. Fund Appl Toxicol 34:201–222

    Article  CAS  Google Scholar 

  • Ackermann MF, Gasiewicz TA, Lamm KR, Germolec DR, Luster MI (1989) Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-doixin. Toxicol Appl Pharmacol 101:470–480

    Article  CAS  Google Scholar 

  • ACOG (2004) American college of obstetricians and gynecologists. Task force on hormone therapy. Obstet Gynecol 104(S4):112S

    Google Scholar 

  • Actis GC, Debernardo-Venon W, Lagget M, Marzano A, Ottobrelli A, Ponzetto A, Rocca G, Boggio-Bertinet D, Balzola F, Bonino F, Verme G (1995) Hepatotoxicity of intravenous cyclosporin A in patients with acute ulcerative colitis on total parenteral nutrition. Liver 15(6):320–323

    CAS  Google Scholar 

  • Agrawal AK, Shapiro B (2003) Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital. Drug Metab Dispos 31:612–619

    Article  CAS  Google Scholar 

  • Agrawal Y, Platz EA, Niparko JK (2008) Prevalence of hearing loss and differences by demographic characteristics among US adults. Arch Intern Med 168(14):1522–1530

    Article  Google Scholar 

  • Albright JW, Albright JF (1998) Impaired natural killer cell function as a consequence of aging. Exp Gerontol 33:13–25

    Article  CAS  Google Scholar 

  • Allard J, Hebert R, Rioux M, Asselin J, Voyer L (2001) Efficacy of a clinical medication review on the number of potentially inappropriate prescriptions prescribed for community-dwelling elderly people. Can Med Assoc J 164(9):1291–1296

    CAS  Google Scholar 

  • Allen JS, Bruss J, Brown CK, Damasio H (2005) Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region. Neurobiol Aging 26:1245–1260

    Article  Google Scholar 

  • Allen JR, Barsotti DA, Van Miller JP, Abrahamson LJ, Lalich JJ (1977) Morphological changes in monkeys consuming a diet containing low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Food Cosmet Toxicol 15:401–410

    Article  CAS  Google Scholar 

  • Allen JR, Carstens LA, Barsotti DA (1974) Residual effects of short-term, low-level exposure of nonhuman primates to polychlorinated biphenyls. Toxicol Appl Pharmacol 30:440–451

    Article  CAS  Google Scholar 

  • Allis JW, Ward TR, Seely JC, Simmons JE (1990) Assessment of hepatic indicators of subchronic carbon tetrachloride injury and recovery in rats. Fundam Appl Toxicol 15:558–570

    Article  CAS  Google Scholar 

  • Aly NM, El-Gendy KS (2000) Effect of dimethoate on the immune system of female mice. J Environ Sci Health Part B 35(1):77–86

    Article  CAS  Google Scholar 

  • Anantharaju A, Feller A, Chedid A (2002) Aging liver: a review. Gerontology 48(6): 343–353

    Article  CAS  Google Scholar 

  • Anderson S, Brenner BM (1986) Effects of aging on the renal glomerulus. Am J Med 80(3): 435–442

    Article  CAS  Google Scholar 

  • Andrews JE (1989) Polychlorinated biphenyl (Aroclor 1254) induced changes in femur morphometry calcium metabolism and nephrotoxicity. Toxicology 57:83–96

    Article  CAS  Google Scholar 

  • Aoyagi M, Fukai N, Ogami K, Yamamoto M, Yamamoto K (1995) Kinetics of 125I-PDGF binding and down-regulation of PDGF receptor in human arterial smooth muscle cell strains during cellular senescence in vitro. J Cell Physiol 164:376–384

    Article  CAS  Google Scholar 

  • Aoyama K (1986) Effects of benzene inhalation on lymphocyte subpopulations and immune response in mice. Toxicol Appl Pharmacol 85:92–101

    Article  CAS  Google Scholar 

  • Aramaki T, Katsuta Y, Sekiyama T, Tsutsui H, Kome-ichi H, Ohsuga M, Satomura K, Yoshimura M (1998) Effects of aging and liver disease upon the pharmacokinetics of nipradilol. Clin Drug Invest 16(3):251–257

    Article  CAS  Google Scholar 

  • Ashcroft GS, Horan MA, Ferguson MW (1997) The effects of aging on wound healing: immunolocalisation of growth factor and their receptors in a murine incisional model. J Anat 190:361–365

    Article  Google Scholar 

  • Ashcroft GS, Horal MA, Ferguson MWJ (1995) The effects of ageing on cutaneous wound healing in mammals. J Anat 187:1–26

    Google Scholar 

  • ATSDR (1999) Toxicological profile for mercury (Update). Department of Health and Human Services, Atlanta, GA

    Google Scholar 

  • ATSDR (1993) Case studies in environmental medicine: cholinesterase-inhibiting pesticide toxicity. Department of Health and Human Services, Atlanta, GA

    Google Scholar 

  • Bach B, Molholm-Hansen J, Kampriann JP, Rasmussen SN, Skorsted Z (1981) Disposition of antipyrine and phenytoin correlated with age and liver volume in man. Clin Pharmacokinet 6:389–396

    Article  CAS  Google Scholar 

  • Bagai A, Thavendiranathan P, Detsky AS (2006) Does this patient have hearing impairment? JAMA 295(4):416–428

    Article  CAS  Google Scholar 

  • Bailey AJ, Knott L (1999) Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly. Exper Gerontol 34(3):337–351

    Article  CAS  Google Scholar 

  • Balin AK, Allen RG (1989) Molecular bases of biologic aging. Clin Geriatr Med 5:1–21

    CAS  Google Scholar 

  • Banks WA, Kastin AJ (1989) Aluminum-induced toxicity: Alterations in membrane function at the blood–brain barrier. Neurosci Biobehav Rev 13:47–53

    Article  CAS  Google Scholar 

  • Banks WA, Farr SA, Morley JE (2000) Permeability of the blood–brain barrier to albumin and insulin in the young and aged SAMP8 mouse. J Gerontol Series A: Biol Sci Med Sci 55: B601–B606

    Article  CAS  Google Scholar 

  • Barnes DG, Dourson M (1988) Reference dose (RfD): description and use in health risk assessments. Regul Toxicol Pharmacol 8:471–486

    Article  CAS  Google Scholar 

  • Barnes R, Jones RC (1967) Carbon tetrachloride poisoning. Am Ind Hyg Assoc J 28:557–560

    Article  CAS  Google Scholar 

  • Barrett JR (2009) Aging. Environmental threats to elders’ neurologic health. Environ Health Perspect 117(1):A17

    Google Scholar 

  • Barsotti DA, Marlar RJ, Allen JR (1976) Reproductive dysfunction in Rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aroclor 1248). Food Cosmet Toxicol 14:99–103

    Article  CAS  Google Scholar 

  • Bauer JH (1993) Age-related changes in the renin–aldosterone system. Physiological effects and clinical implications. Drugs Aging 3(3):238–245

    Article  CAS  Google Scholar 

  • Baylis C (2005) Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system. Exp Gerontol 40(4):271–278

    Article  CAS  Google Scholar 

  • Beauregard S, Gilchrest BA (1987) A survey of skin problems and skin care regimens in the elderly. Arch Dermatol 123(12):1638–1643

    Article  CAS  Google Scholar 

  • Beers MH, Porter RS, Jones TV, Kaplan JL, Berkwits M (eds) (2006) The Merck manual, 18th edn. Merck Research Laboratories, Whitehouse Station, NJ

    Google Scholar 

  • Beers MH, Berkow R (eds) (2000) Merck manual of geriatrics, 10th edn. Merck Research Laboratories, Whitehouse Station, NJ

    Google Scholar 

  • Begin ME, Langlois MF, Lorrain D, Cunnane SC (2008) Thyroid function and cognition during aging. Curr Gerontol Geriatr Res. doi:10.1155/2008/474868

    Google Scholar 

  • Belmin J, Levy BI, Michel JB (1994) Changes in the renin–angiotensin–aldosterone axis in later life. Drugs Aging 5(5):391–400

    Article  CAS  Google Scholar 

  • Benetos A, Laurent S, Hoeks AP, Boutouyrie PH, Safar ME (1993) Arterial alterations with aging and high blood pressure: a non-invasive study of carotid and femoral arteries. Atheroscler Thromb: 13:90–97

    Article  CAS  Google Scholar 

  • Benjamin IL, Jalil JE, Tan L-B, Cho K, Weber KT, Clark WA (1989) Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res 65:657–670

    Article  CAS  Google Scholar 

  • Ben-Yehuda A, Weksler ME (1992) Host resistance and the immune system. Clin Geriatr Med 8:701–711

    CAS  Google Scholar 

  • Beyer WE, Palache AM, Baljet M, Masurel N (1989) Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine 7(5):385–394

    Article  CAS  Google Scholar 

  • Bianchi L, Holt P, James OFW, Butler RN (eds) (1988) Aging in liver and gastrointestinal tract. Kluwer, Hingham, MA

    Google Scholar 

  • Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW, Drezner MK (2007) Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab 92(6):2130–2135

    Article  CAS  Google Scholar 

  • Birnbaum LS (1991) Pharmacokinetic basis of age-related changes in sensitivity to toxicants. Ann Rev Pharmacol 31:101–128

    Article  CAS  Google Scholar 

  • Blair PC, Thompson MB, Wilson RE, Esber HH, Maronpot RR (1991) Correlation of changes in serum analytes and hepatic histopathology in rats exposed to carbon tetrachloride. Toxicol Lett 55:149–159

    Article  CAS  Google Scholar 

  • Blakley BR (1985) The effect of cadmium chloride on the immune response in mice. Can J Comp Med 49:104–108

    CAS  Google Scholar 

  • Blaylock BL, Holladay SD, Comment CE, HeGindel J, Luster MI (1992) Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol Appl Pharmacol 112:207–213

    Article  CAS  Google Scholar 

  • Bogardus ST, Yueh B, Shekelle PG (2003) Screening and management of adult hearing loss in primary care: clinical applications. JAMA 289(15):1986–1990

    Article  Google Scholar 

  • Bonnick SL (1994) The osteoporosis handbook. Taylor, Dallas, TX

    Google Scholar 

  • Born J, Uthgenannt D, Dodt C, Ninninghoff D, Ringvolt E, Wagner T, Fehm HL (1995) Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech Ageing Dev 84:113–126

    Article  CAS  Google Scholar 

  • Boyd E (1932) The weight of the thymus gland in health and disease. Am J Dis Child 43: 1162–1214 (as cited in Francis et al. 1985)

    Google Scholar 

  • Brace H, Latimer M, Winn P (1997) Neurotoxicity, blood–brain barrier breakdown, demyelination and remyelination associated with NMDA-induced lesions of the rat lateral hypothalamus. Brain Res Bull 43:447–455

    Article  CAS  Google Scholar 

  • Branca F (1997) Calcium, micronutrients and physical activity to maximize bone mass during growth. Food Nutr Agric 20:44–48

    Google Scholar 

  • Branchet MC, Boisnic S, Frances C, Robert AM (1990) Skin thickness changes in normal aging. Gerontology 36(1):28–35

    Article  CAS  Google Scholar 

  • Braverman IM (2000) The cutaneous microcirculation. J Invest Dermatol Symp Proc 5: 3–9

    Article  CAS  Google Scholar 

  • Braverman IM, Fonferko E (1982) Studies in cutaneous aging. II. The microvasculature. J Invest Dermatol 78:444–448

    Article  CAS  Google Scholar 

  • Bruckner JV, MacKenzie WF, Muralidhara S, Luthra R, Kyle GM, Acosta D (1986) Oral toxicity of carbon tetrachloride: acute, subacute and subchronic studies in rats. Fundam Appl Toxicol 6:16–34

    Article  CAS  Google Scholar 

  • Bruckner JV, Jiang WD, Brown JM, Putcha CK, Chuand VJ, Stella J (1977) The influence of ingestion of environmentally encountered levels of a commercial polychlorinated biphenyl mixture (Aroclor 1254) on drug metabolism in the rat. J Pharmacol Exp Ther 202:22–31

    CAS  Google Scholar 

  • Bruckner JV, Khanna KL, Cornish HH (1973) Biological responses of the rat to polychlorinated biphenyls. Toxicol Appl Pharmacol 24:434–448

    Article  CAS  Google Scholar 

  • Budnitz DS, Shehab N, Kegler SR, Richards CL (2007) Medication use leading to emergency department visits for adverse drug effects in older adults. Ann Intern Med 147:755–765

    Google Scholar 

  • Burger H, de Laet CEDH, van Daele PLA, Weel AEAM, Witterman JCM, Hofman A, Polsw HAP (1998) Risk factors for increased bone lows in an elderly population: the Rotterdam study. Am J Epidemiol 147:871–879

    Article  CAS  Google Scholar 

  • Buschbacher RM, Koch J (1999) Race effect on nerve conduction studies: Acomparison between 50 blacks and 50 whites. Arch Phys Med Rehabil 80:536–539

    Article  CAS  Google Scholar 

  • Butcher SK, Chahal H, Nayak L, Sinclair A, Henriques NV, Sapey E, O’Mahony D, Lord JM (2001) Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 70:881–886

    CAS  Google Scholar 

  • Campbell VA, Crews JE, Moriarty DG, Zack MM, Blackman DK (1999) Surveillance for sensory impairment, activity limitation, and health-related quality of life among older adults – United States, 1993–1997. Morb Mortal Wkly Rep 48:131–156

    CAS  Google Scholar 

  • Carter JW (1985) Effects of dietary PCBs (Aroclor 1254) on serum levels of lipoprotein cholesterol in Fischer rats. Bull Environ Contam Toxicol 34:427–431

    Article  CAS  Google Scholar 

  • Carter JW, Koo SI (1984) Effects of dietary Aroclor 1254 (PCBs) on serum levels of lipoprotein cholesterol and tissue distribution of zinc, copper and calcium in Fischer rats. Nutr Rep Int 29:223–232

    CAS  Google Scholar 

  • Castle S, Uyemura K, Wong W, Modlin R, Efros R (1997) Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech Ageing Dev 94:7–16

    Article  CAS  Google Scholar 

  • CDC (2004) The state of aging and health in America 2004. Merck Institute of Aging & Health, Washington, DC

    Google Scholar 

  • Cha CW (1987) A study on the effect of garlic to the heavy metal poisoning of rat. J Korean Med Sci 2:213–224

    CAS  Google Scholar 

  • Chahal HS, Drake WM (2007) The endocrine system and aging. J Pathol 211(2):173–180

    Article  CAS  Google Scholar 

  • Chakraborti AK, Saha KC (1987) Arsenical dermatosis from tubewell water in West Bengal. Indian J Med Res 85:326–334

    Google Scholar 

  • Chandra AM, Campbell GA, Reddy G, Qualls CW (1999) Neurotoxicity of 1,3,5-trinitrobenzene (TNB): immunohistochemical study of cerebrovascular permeability. Vet Pathol 36:212–220

    Article  CAS  Google Scholar 

  • Chang E, Yang J, Nagavarapu U, Herron GS (2002) Aging and survival of cutaneous microvasculature. J Invest Dermatol 118:7542–7758

    Article  Google Scholar 

  • Chen C-H, Nakayama M, Nevo E, Fetics BJ, Maughan WL, Kass DA (1998) Coupled systolic-ventricular and vascular stiffening with age. J Am Coll Cardiol 32:1221–1227

    Article  CAS  Google Scholar 

  • Chen HS, Kuo CS (1989) Relationship between respiratory muscle function and age, sex, and other factors. J Appl Physiol 66:943–948

    CAS  Google Scholar 

  • Chertkov JL, Lutton JD, Jiang S, da Silva JL, Abraham NG (1992) Hematopoietic effects of benzene inhalation assessed by murine long-term bone marrow culture. J Clin Lab Med 119:412–419

    CAS  Google Scholar 

  • Chisari C, Bresci M, Licitra R, Stampacchia G, Rossi B (2002) A functional study of oxidative muscle efficiency in older people. Basic Appl Myol 12(5):209–212

    Google Scholar 

  • Chou SJ, Holler J, De Rosa CT (1998) Minimal risk levels for hazardous substances. J Clean Technol Environ Toxicol Occup Med 7(1):1–24

    CAS  Google Scholar 

  • Chutka DS, Flemming KC, Evans MP, Evans JM, Andrews KL (1996) Urinary incontinence in the elderly population. Mayo Clin Proc 71:93–101

    Article  CAS  Google Scholar 

  • Clewell RA, Merrill EA, Narayanan L, Gearhart JM, Robinson PJ (2004) Evidence for competitive inhibition of iodide uptake by perchlorate and translocation of perchlorate in to the thyroid. Int J Toxicol 23(1):17–23

    Article  CAS  Google Scholar 

  • Cody RP, Strawderman WW, Kipen HM (1993) Hematologic effects of benzene. Job-specific trends during the first year of employment among a cohort of benzene-exposed rubber workers. J Occup Med 35(8):776–782

    Article  CAS  Google Scholar 

  • Col N, Fanale JE, Kronholm P (1990) The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med 150:841–845

    Article  CAS  Google Scholar 

  • Colige A, Nusgens B, Lapiere CM (1990) Response to epidermal growth factor of skin fibroblasts from donors of varying age is modulated by the extracellular matrix. J Cell Physiol 145: 450–457

    Article  CAS  Google Scholar 

  • Colonna-Romano G, Aquino A, Bulati M, Di Lorenzo G, Listi F, Vitello S, Lio D, Candore G, Clesi G, Caruso C (2006) Memory B cell subpopulations in the aged. Rejuvenation Res 9: 149–152

    Article  CAS  Google Scholar 

  • Condie LW, Laurie RD, Mills T, Robinson M, Bercz JP (1986) Effect of gavage vehicle on hepatotoxicity of carbon tetrachloride in CD-1 mice: corn oil versus Tween-60 aqueous emulsion. Fundam Appl Toxicol 7:199–206

    Article  CAS  Google Scholar 

  • Cooke GA, AL-Timman JK, Marshal P, Wright DJ, Hainsworth R, TanL-B (1998) Physiological cardiac reserve: development of a non-invasive method and first estimates in man. Heart 79:289–294

    CAS  Google Scholar 

  • Corpas E, Harman SM, Blackburn MR (1993) Human growth hormone and human aging. Endocr Rev 14:20–39

    CAS  Google Scholar 

  • Costa-Bauza A, Ramis M, Montesinos V, Grases F, Conte A, Piza P, Pieras E (2007) Type of renal calculi: variation with age and sex. World J Urol 25(4):415–421

    Article  Google Scholar 

  • Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B, Harwood M, Hinds S, Press GA (2000) Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 216(3):672–682

    CAS  Google Scholar 

  • Cronkite EP, Drew RT, Inoue T, Bullis JE (1989) Hematotoxicity and carcinogenicity of inhaled benzene. Environ Health Perspect 82:97–198

    Article  CAS  Google Scholar 

  • Cronkite EP (1986) Benzene hematotoxicity and leukemogenesis. Blood Cells 12:129–137

    CAS  Google Scholar 

  • Cronkite EP, Drew RT, InoueT, Bullis JE (1985) Benzene hematotoxicity and leukemogenesis. Am J Ind Med 7:447–456

    Article  CAS  Google Scholar 

  • Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, Mottino AD, Sanchez Pozzi EJ (2006) Galactosamine prevents ethinylestradiol-induced cholestasis. Drug Metab Disp DOI: 10.1124/dmd.106.009308

    Google Scholar 

  • David A, Frantik E, Holusa R, Novakova O (1981) Role of time and concentration on carbon tetrachloride in rats. Int Arch Occup Environ Health 48:49–60

    Article  CAS  Google Scholar 

  • Davis BE, Koh HK (1992) Faces going up in smoke: a dermatologic opportunity for cancer prevention. Arch Dermatol 128:1106–1107

    Article  CAS  Google Scholar 

  • De Heer C, Verlaan APJ, Penninks AH, Vos JG, Schuurman HJ, Van Loveren H (1994) Time course of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced thymic atrophy in the Wistar rat. Toxicol Appl Pharmacol 128:97–104

    Article  Google Scholar 

  • De Krey GK, Kerkvliet NI (1995) Suppression of cytotoxic T lymphocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin occurs in vivo, but not in vitro, and is independent of corticosterone elevation. Toxicology 97:105–112

    Article  Google Scholar 

  • De la Cruz Rodriguez LC, Araujo CR, Posleman SE, Del Rosario Rey M (2007) Hepatotoxic effect of cyclosporin A in the mitochondrial respiratory chain. J Appl Toxicol 27:310–317

    Article  CAS  Google Scholar 

  • De la Fuente M, Minano M, Victor VM, Del Rio M, Ferrabdez MD, Diez A, Miguel J (1998) Relation between exploratory activity and immune function in aged mice: a preliminary study. Mech Aging Dev 102:263–277

    Article  Google Scholar 

  • De Wall EJ, Schuurman H-J, Loeber JG, Van Loveren H, Vos JG (1992) Alterations in cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): an (immuno)histological study. Toxicol Appl Pharmacol 115(1): 80–88

    Article  Google Scholar 

  • DeCaprio AP, McMartin DM, O’Keefe PW, Rey R, Silkworth JB, Kaminsky LS (1986) Subchronic oral toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the guinea pig: comparisons with a PCB-containing transformer fluid pyrolysate. Fundam Appl Toxicol 6:454–463

    Article  CAS  Google Scholar 

  • Delarosa O, Pawelec G, Peralbo E, Wikby A, Mariani E, Mocchegiani E, Tarazona R, Solana R (2006) Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 7:471–481

    Article  CAS  Google Scholar 

  • Deng Y, Jing Y, Campbell AE, Gravenstein S (2004) Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol 172(6):3437–3446

    CAS  Google Scholar 

  • Dennison E, Hindmarsh P, Fall C, Kellingray S, Barker D, Phillips D, Cooper C (1999) Profiles of endogenous circulating cortisol and bone mineral density in healthy elderly men. J Clin Endocrinol Metab 84(9):3058–3063

    Article  CAS  Google Scholar 

  • DeVeale B, Brummel T, Seroude L (2004) Immunity and aging: the enemy within? Aging Cell 2004:195–208

    Article  CAS  Google Scholar 

  • Dieter MP, Boorman GA, Jameson CW, Eustis SL, Uriah LC (1992) Development of renal toxicity in F344 rats gavaged with mercuric-chloride for 2 weeks, or 2,4,6, 15, and 24 months. J Toxicol Environ Health 36(4):319–340

    Article  CAS  Google Scholar 

  • Dieter MP, Luster MI, Boorman GA, Jameson GW, Cox JW (1983) Immunological and biochemical responses in mice treated with mercuric chloride. Toxicol Appl Pharmacol 68:218–228

    Article  CAS  Google Scholar 

  • Dilger K, Hofmann U, Klotz U (2000) Enzyme induction in the elderly: effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone. Clin Pharmacol Therapeut 67: 512–520

    Article  CAS  Google Scholar 

  • Diliberto JJ, Akubue PI, Luebke RW, Birnbaum LS (1995) Dose–response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Toxicol Appl Pharmacol 130:197–208

    Article  CAS  Google Scholar 

  • Ding A, Hwang S, Schwab R (1994) Effect of aging on murine macrophages – Diminished response to IFN-gamma for enhanced oxidative metabolism. J Immunol 153:2146–2152

    CAS  Google Scholar 

  • Donnini A, Argentati K, Mancini R, Smoriesi A, Bartozzi B, Benardini G, Provinciali M. (2002) Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp Gerontol 37(8–9):1097–1112

    Article  CAS  Google Scholar 

  • Dorfman LJ, Bosley TM (1979) Age-related changes in peripheral and central nerve conduction in man. Neurology 29:38–44

    Article  CAS  Google Scholar 

  • Dow (1992) Effects of benzene vapor in the pig and rat. I. Pertaining to hematology and immunology with cover letter dated 05/14/92. Submitted to the U.S. Environmental Protection Agency under TSCA section 8E. OTS0539784

    Google Scholar 

  • Edelson GW, Kleerekoper M (1995) Bone mass, bone loss, and fractures. In: Matkovic V (ed) Physical medicine and rehabilitation clinics of North America. WB Saunders, Philadelphia, PA, pp 455–464

    Google Scholar 

  • Ehrsam RE, Perruchaud A, Oberholzer M, Burkart F, Herzog F (1983) Influence of age on pulmonary hemodynamics at rest and during supine exercise. Clin Sci 65:653–660

    CAS  Google Scholar 

  • Einerson TR (1993) Drug-related hospital admissions. Ann Pharmacother 27:832–840

    Google Scholar 

  • El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, Ahmad H, Uitto J (2002) Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol 11:398–405

    Article  CAS  Google Scholar 

  • Emeigh Hart SG, Wyand SD, Khairallah EA, Cohen SD (1996) Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding. Toxicol Appl Pharmacol 136:161–169

    Article  CAS  Google Scholar 

  • Emeigh Hart SG, Beierschmitt WP, Wyand DS, Khairallah EA, Cohen SD (1994) Acetaminophen nephrotoxicity in CD-1 mice. I. Evidence of a role for in situ activation in selective covalent binding and toxicity. Toxicol Appl Pharmacol 126:267–275

    Article  Google Scholar 

  • Emmanuelli G, Lanzio M, Anfossi T, Romano S, Anfossi G, Calamuggi G (1986) Influence of age on polymorphonuclear leukocytes in vitro: phagocytic activity in healthy human subjects. Gerontology 32:308–316

    Article  Google Scholar 

  • Endress DB, Morgan CH, Garry PJ, Omdahl JL (1987) Age related changes in serum immunoreactive parathyroid hormone and its biological activity in healthy men and women. J Clin Endocrinol Metab 65:724–731

    Article  Google Scholar 

  • Engelke M, Jensen JM, Ekanayake-Mudiyanselage S, Proksch E (1997) Effects of xerosis and ageing on epidermal proliferation and differentiation. Br J Dermatol 137:219–225

    Article  CAS  Google Scholar 

  • Enright PL, Kronmal RA, Higgins M, Schenker M, Haponik EF (1993) Spirometry M.L. Reference values for women and men 65–85 years of age. Cardiovascular Health Study. Am Rev Resp Dis 147:125–133

    Article  CAS  Google Scholar 

  • Enright PL, Kronmal RA, Manolio TA, Schenker M, Hyatt RE (1994) Respiratory muscle strength in the elderly: correlates and reference values. Am J Respir Crit Care Med 149:430–438

    CAS  Google Scholar 

  • Erdogan MF (2003) Thiocyanate overload and thyroid disease. Biofactors 19(3–4):107–111

    Article  CAS  Google Scholar 

  • Fan F, Wierda D, Rozman KK (1996) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. Toxicology 106:221–228

    Article  CAS  Google Scholar 

  • Fanelli A, Berlin WK, Grollman EF (1995) Inhibition of iodide transport in rat thyroid cells using n-substituted anthranilic acid derivatives. Thyroid 5(3):223–230

    CAS  Google Scholar 

  • Farber BF, Moellering RC Jr (1983) Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981. Antimicrob Agents Chemother 23:138–141

    Article  CAS  Google Scholar 

  • Farrell SE (2009) Toxicity, acetaminophen: eMedicine in MedScape by WebMD. http://emedicine.medscape.com/article/820200-overview May 24, 2010

  • Feldman ML (1976) Aging changes the morphology of cortical dendrites. In: Terry RD, Gershon S (eds) Neurobiology of aging. Raven Press, New York, NY, p 11

    Google Scholar 

  • Fenske NA, Lober CW (1986) Structural and functional changes of normal aging skin. J Am Acad Dermatol 15:571–585

    Article  CAS  Google Scholar 

  • Fickert P, Zatloukal K (2000) Pathogenesis of alcoholic liver disease. In: Zernig G, Saria A, Kurz M, O’Malley S (eds) Handbook of alcoholism. CRC Press, Boca Raton, FL, pp 317–323

    Chapter  Google Scholar 

  • Fingerle H, Fischer G, Classen HG (1982) Failure to produce hypertension in rats by chronic exposure to cadmium. Food Chem Toxicol 20:301–306

    Article  CAS  Google Scholar 

  • Forbes GB, Halloran E (1965) The adult decline in lean body mass. Hum Biol 48:162–173

    Google Scholar 

  • Fournier M, Chevalier G, Nadeau D, Trotter B, Krzystyniak K (1988) Virus–pesticide interactions with murine cellular immunity after sublethal exposure to dieldrin and aminocarb. J Toxicol Environ Health 25:103–118

    Article  CAS  Google Scholar 

  • Francis IR, Gazer GM, Bookstein FL, Gross BH (1985) The thymus: reexamination of age-related changes in size and shape. Am J Roentgen 145(2):249–254

    CAS  Google Scholar 

  • Franzblau A, Lilis R (1989) Acute arsenic intoxication from environmental arsenic exposure. Arch Environ Health 44(6):385–390

    Article  CAS  Google Scholar 

  • Freinkel N, Ingbar SH (1955) Effect of metabolic inhibitors upon iodide transport in sheep thyroid slices. J Clin Endocrinol Metab 15(5):598–615

    Article  CAS  Google Scholar 

  • Ganjavi H, Herrmann N, Rochon PA, Sharma P, Lee M, Cassel D, Freedman M, Black SE, Lanctot KL (2007) Adverse drug events in cognitively impaired elderly patients. Dement Geriatr Cogn Disord 23(6):395–400

    Article  Google Scholar 

  • Garfinkel S, Hu X, Prudovsky IA, McMahon G, Kapnik EM, McDowell SD, Maciag T (1996a) FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1-substrates. J Cell Biol 134:783–791

    Article  CAS  Google Scholar 

  • Garfinkel S, Wessendorf JH, Hu X, Maciag T (1996b) The human diploid fibroblast senescence pathway is independent of interlukin-1 alpha mRNA. Biochim Biophys Acta 1314:109–119

    Article  CAS  Google Scholar 

  • Geokas MC, Lakatta EG, Makinodan T, Timaras PS (1990) The aging process. Ann Intern Med 113:455–466

    CAS  Google Scholar 

  • George DK, Crawford DH (1996) Antibacterial-induced hepatotoxicity. Incidence, prevention and management. Drug Saf 15:79–85

    Article  CAS  Google Scholar 

  • Germain AM, Carvajal JA, Glasinovic JC, Kato S, Williamson C (2002) Intrahepatic cholestasis of pregnancy: an intriguing pregnancy-specific disorder. Gynecol Invest 9:10–14

    Article  CAS  Google Scholar 

  • Geubel AP, De Galocsy C, Alves N, Rahier J, Dive C (1991) Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 100(6):1701–1709

    CAS  Google Scholar 

  • Ghia P, Melchers F, Rolink AG (2000) Age-dependent changes in B lymphocyte development in man and mouse. Exper Gerontol 35:159–165

    Article  CAS  Google Scholar 

  • Ghia P, ten Boekel E, Sanz E, de la Hera A, Rolink A, Melchers F (1996) Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J Exp Med 184: 2217–2229

    Article  CAS  Google Scholar 

  • Ghorbel H, Fetoui H, Mahjoubi A, Guermazi F, Zeghal N (2008) Thiocyanate effects on thyroid function of weaned mice. C R Biol 331(4):262–271

    Article  CAS  Google Scholar 

  • Gilchrest BA, Murphy GF, Soter NA (1982) Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermis. J Invest Dermatol 79(2):85–88

    Article  CAS  Google Scholar 

  • Gilchrest BA, Blog FB, Szabo G (1979) Effects of aging and chronic sun exposure on melanocytes in human skin. J Invest Dermatol 73:141–143

    Article  CAS  Google Scholar 

  • Gill DP, Jenkins VK, Kempen RR, Ellis S (1980) The importance of pluripotential stem cells in benzene toxicity. Toxicology 16:163–171

    Article  CAS  Google Scholar 

  • Globerson A (1995) T lymphocytes and aging. Int Arch Allergy Immunol 107:491–497

    Article  CAS  Google Scholar 

  • Goldspink DF, Burniston JG, Tan L-B (2003) Cardiomyocyte death and the aging and failing heart. Exp Physiol 88(3):447–458

    Article  CAS  Google Scholar 

  • Goldstein JA, Hickman P, Jue DL (1974) Experimental hepatic porphyria induced by polychlorinated biphenyls. Toxicol Appl Pharmacol 27:437–448

    Article  CAS  Google Scholar 

  • Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21–36

    Article  CAS  Google Scholar 

  • Goodwin K, Viboud C, Simonsen L (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24:1159–1169

    Article  CAS  Google Scholar 

  • Goodwin JS, Messner RP (1979) Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70. J Clin Invest 64(2):434–439

    Article  CAS  Google Scholar 

  • Gopinath B, Rochtchina E, Wang JJ, Schneider J, Leeder SR, Mitchell P (2009) Prevalence of age-related hearing loss in older adults: blue mountains study. Arch Intern Med 169(4):415–416

    Article  Google Scholar 

  • Gordon HL, Hunter JM (1982) Ethylene glycol poisoning: a case report. Anaesthesia 37(3): 332–338

    Article  CAS  Google Scholar 

  • Goukassian D, Ga F, Yarr M, Eller MS, Nehal US, Gilchrist BA (2000) Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J 14:1325–1334

    Article  CAS  Google Scholar 

  • Gourtsoyiannis N, Prassopouolos P, Cavouras D, Pantelidis N (1990) The thickness of the renal parenchyma decreases with age: a CT study of 360 patients. Am J Roentgen 155:541–544

    CAS  Google Scholar 

  • Graham JA, Miller FJ, Daniels MJ, Payne EA, Gardner DE (1978) Influence of cadmium, nickel, and chromium on primary immunity in mice. Environ Res 16:77–87

    Article  CAS  Google Scholar 

  • Gray LE Jr, Ostby J, Marshall R, Andrews J (1993) Reproductive and thyroid effects of low-level polychlorinated biphenyl (Aroclor 1254) exposure. Fundam Appl Toxicol 20(3):288–294

    Article  CAS  Google Scholar 

  • Gray A, Feldman HA, McKinlay JB, Longcope C (1991) Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab 73(5):1016–1025

    Article  CAS  Google Scholar 

  • Gross PA, Hermogenes AW, Sacks HS, Lau J, Levandowski RA (1995) The efficacy of influenza vaccine in elderly persons: a meta-analysis and review of the literature. Ann Intern Med 123:518–527

    CAS  Google Scholar 

  • Greendale GA, Unger JB, Rowe JW, Seeman TE (1999) The relation between cortisol excretion and fractures in healthy older people. J Am Geriatr Soc 47(7):799–803

    CAS  Google Scholar 

  • Grimley Evans J (2000) Ageing and medicine. J Intern Med 247:159–167

    Article  CAS  Google Scholar 

  • Grove GL, Kligman AM (1983) Age-associated changes in human epidermal cell renewal. J Gerontol 38:137–142

    Article  CAS  Google Scholar 

  • Graugaard-Jensen C, Schmidt F, Thomsen HF, Djurhuus JC (2008) Normal voiding patterns assessed by means of a frequency–volume chart. Scand J Urol Nephrol 42:269–273

    Article  Google Scholar 

  • Grubeck-Loebenstein B (1997) Changes in the aging immune system. Biologicals 25(2):205–208

    Article  CAS  Google Scholar 

  • Guha Mazumder DN, Chakraborty AK, Ghose A, Gupta JD, Chakraborty DP, Dey SB, Chattopadhyay N (1988) Chronic arsenic toxicity from drinking tubewell water in rural West Bengal. Bull WHO 66(4):499–506

    CAS  Google Scholar 

  • Gurnell EM, Chatterjee VK (2001) Dehydroepiandrosterone replacement therapy. Eur J Endocrinol 145(2):103–106

    Article  CAS  Google Scholar 

  • Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA (2002) Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab 87(8):3632–3639

    Article  CAS  Google Scholar 

  • Hamilton HJ, Gallagher PF, O’Mahony D (2009) Inappropriate prescribing and adverse drug events in older people. BMC Geriatr 9:5. doi: 10.1186/1471-2318-9-5

    Article  Google Scholar 

  • Hanberg A, Hakansson H, Ahlborg UG (1989) “ED50” for TCDD-induction of body weight gain, liver enlargement, and thymic atrophy in Hartley guinea pigs, Sprague-Dawley rats, C57BL/6 mice, and golden Syrian hamsters. Chemosphere 9:813–816

    Article  Google Scholar 

  • Hanlon JT, Schmader KE, Koronkowski MJ, Weinberger M, Landsman PB, Samsa GP, Lewis IK (1997) Adverse drug events in high risk older outpatients. J Am Geriatr Soc 45:945–948

    CAS  Google Scholar 

  • Hannan MT, Felson DT, Anderson JJ (1992) Bone mineral density in elderly men and women: results from the Framingham osteoporosis study. J Bone Miner Res 7:547–553

    Article  CAS  Google Scholar 

  • Hardman JG, Limbird LE (2001) Goodman & Gilman’s the pharmacological basis of therapeutics, 10th edn. McGraw-Hill Medical Publishing Division, New York, NY

    Google Scholar 

  • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab 86(2):724–731

    Article  CAS  Google Scholar 

  • Harman SM, Tsitouras PD (1980) Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 51(1):35–40

    Article  CAS  Google Scholar 

  • Harman D (1981) The aging process. Proc Natl Acad Sci USA 78(11):7124–7128

    Article  CAS  Google Scholar 

  • Hawkley LC, Cacioppo JT (2004) Stress and the aging immune system. Brain Behav Immun 18:114–119

    Article  CAS  Google Scholar 

  • Hayes JR, Condie LW Jr, Egle JL Jr, Borzelleca JF (1987) The acute and subchronic toxicity in rats of trans-1,2-dichloroethylene in drinking water. J Am Coll Toxicol 6:471–478

    Article  CAS  Google Scholar 

  • Hazzard WR, Blass JP, Ettinger WH, Jr, Halter JB, Ouslander JG (1999) Principles of geriatric medicine and gerontology, 4th edn. McGraw-Hill, Health Professions Division, New York, NY, pp 104–116

    Google Scholar 

  • Heaton PC, Fenwick SR, Brewer DE (2007) Association between tetracycline or doxycycline and hepatotoxicity: a population I case–control study. J Clin Pharm Ther 32(5):483–487

    Article  CAS  Google Scholar 

  • Helzer EP, Cauley JA, Pratt SR, Wisniewski SR, Zmuda JM, Talbott EO, de Rekeneire N, Harris TB, Rubin SM, Simonsick EM, Tylavsky FA, Newman Anne B (2005) Race and sex differences in age-related hearing loss: the health, aging and body composition study. J Am Geriatr Soc 53(12):2119–2127

    Article  Google Scholar 

  • Henck JW, Quast JF, Rampy LW (1979) A comparison of four mouse strains exposed to subchronically inhaled vinylidene chloride (VDC). Toxicology Research Laboratory, Health and Environmental Science, Dow Chemical USA, Midland, MI

    Google Scholar 

  • Hernandez-Zavala A, Del Razo LM, Aguilar C, Garcia-Vargas GG, Borja VH, Cebrian ME (1998) Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico. Toxicol Lett 99:79–84

    Article  CAS  Google Scholar 

  • Hodgson E, Rose RL (2007) Human metabolic interactions of environmental chemicals. J Biochem Mol Toxicol 21(4):182–186

    Article  CAS  Google Scholar 

  • Holick MF, Matsuoka LY, Wortsman J (1989) Age, vitamin D, and solar ultraviolet. Lancet 2: 1104–1105

    Article  CAS  Google Scholar 

  • Holmes KL, Schnitzlein CT, Perkins EH, Tew JC (1984) The effect of age on antigen retention in lymphoid follicles and collagenous tissue of mice. Mech Ageing Dev 25:243–249

    Article  CAS  Google Scholar 

  • Holsapple MP, Dooley RK, McNerney PJ, McCay JA (1986) Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured spleen cells from (C57BL/6 × C3H)F1 and DBA/2 mice. Immunopharmacology 12:175–186

    Article  CAS  Google Scholar 

  • Homma Y, Imajo C, Takahashi S, Kawabe K, Aso Y (1994) Urinary symptoms and urodynamics in a normal elderly population. Scand J Urol Nephrol Suppl 157:27–30

    CAS  Google Scholar 

  • Horan MA, Ashcroft GS (1997) Ageing, defence mechanisms and the immune system. Age Aging 26(S4):15–19

    Article  Google Scholar 

  • Hui-Ling L, Chen J-T, Ma T-C, Chang Y-S (2008) Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan. Arch Gerontol Geriatr 47:99–107

    Article  Google Scholar 

  • Hultman P, Enestrom S (1992) Dose–response studies in murine mercury-induced autoimmunity and immune-complex disease. Toxicol Appl Pharmacol 113(2):199–208

    Article  CAS  Google Scholar 

  • Hunt CM, Westerkarn SR, Stave M, Wilson J (1992a) Hepatic cytochrome p-4503A (CYP3A) activity in the elderly. Mech Ageing Dev 64:189–199

    Article  CAS  Google Scholar 

  • Hunt CM, Westerkam WR, Stave GM (1992b) Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 44:275–283

    Article  CAS  Google Scholar 

  • Hutterer F, Schaffner F, Klion FM, Popper H (1968) Hypertrophic, hypoactive smooth endoplasmic reticulum: a sensitive indicator of hepatotoxicity exemplified by dieldrin. Science 161(3845):1017–1019

    Article  CAS  Google Scholar 

  • Institoris L, Siroke O, Desi I, Undeger U (1999) Immunotoxicological examination of repeated dose combined exposure by dimethoate and two heavy metals in rats. Hum Exp Toxicol 18(2):88–94

    Article  CAS  Google Scholar 

  • IOM (1997) Institute of Medicine. DRI Dietary Reference Intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. Standing Committee on the scientific evaluation of dietary reference intakes. Food and Nutrition Board, Institute of Medicine, National Academies Press, Washington, DC

    Google Scholar 

  • Ishimaru T, Pages L, Horton R (1977) Altered metabolism of androgens in elderly men with benign prostatic hyperplasia. J Clin Endocrinol Metab 45(4):695–701

    Article  CAS  Google Scholar 

  • Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ (2002) Mechanisms of hepatotoxicity. Toxicol Sci 65:166–176

    Article  CAS  Google Scholar 

  • Jernigan TL, Archibald SL, Fennema-Notestine C, Gamsi AC, Stout JC, Bonner J, Hesselink J (2001) Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol Aging 22:581–594

    Article  CAS  Google Scholar 

  • Johnson SR (1998) Menopause and hormone replacement therapy. Med Clin North Am 82(2): 297–320

    Article  CAS  Google Scholar 

  • Jones A, Morton I, Hobson L, Evans GS, Everard ML (2006) Differentiation and immune function of human dendritic cells following infection by respiratory syncytial virus. Clin Exp Immunol 143(3):513–522

    Article  CAS  Google Scholar 

  • Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA (1994) Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 309:691–695

    Article  CAS  Google Scholar 

  • Jonker D, Woutersen RA, van Bladeren PJ, Til HP, Feron VJ (1993) Subacute (4-week) oral toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. Food Chem Toxicol 31(2):125–136

    Article  CAS  Google Scholar 

  • Jourdan M, Vaubourdolle M, Cynober L, Aussel C (2004) Effect of aging on liver functions – an experimental study in a perfused rat liver model. Exp Gerontol 39(9):1341–1446

    Article  CAS  Google Scholar 

  • Junius-Walker U, Theile G, Hummers-Pradier E (2006) Prevalence and predictors of polypharmacy among older primary care patients in Germany. Fam Pract. doi:10,1903/fampra/ cm1067

    Google Scholar 

  • Juurlink DN, Mamdani M, Kopp A, Laupacis A, Redeimeier DA (2003) Drug–drug interactions among elderly patients hospitalized for drug toxicity. JAMA 289(13):1599–1600

    Article  Google Scholar 

  • Jyrkka J, Enlund H, Korhonen MJ, Sulkava R, Hartikainen S (2009) Patterns of drug use and factors associated with polypharmacy and excessive polypharmacy in elderly persons. Drugs Aging 26(6):493–503

    Article  Google Scholar 

  • Kalaria RN, Mitchell MJ, Harik SI (1987) Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood–brain barrier monoamine oxidase activity. Proc Natl Acad Sci USA 84:3521–3525

    Article  CAS  Google Scholar 

  • Kamijo Y, Soma K, Asari Y, Ohwada T (1998) Survival after massive arsenic poisoning self-treated by high fluid intake. Clin Toxicol 36(1–2):27–29

    Article  CAS  Google Scholar 

  • Kampmann JP, Sinding J, Moller-Jorgensen I (1975) Effect of age on liver function. Geriatrics 30:19–95

    Google Scholar 

  • Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J (2004) Age-associated change in the frequency of memory CD4+ T cell responses to influenza vaccine. J Immunol 173:673–681

    CAS  Google Scholar 

  • Kaplan C, Pasternack B, Shah H, Gallo G (1975) Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 80:227–234

    CAS  Google Scholar 

  • Kaplowitz N, Aw TY, Simon FR, Stolz A (1986) Drug-induced hepatotoxicity. Ann Inter Med 104(6):5A6

    Google Scholar 

  • Kappel B, Olsen S (1980) Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex: a quantitative study. Virchows Arch A Pathol Anat Histol 387(3):271–277

    Article  CAS  Google Scholar 

  • Kareskay L, Tjernlunel UM, Forsum U, Peterson PA (1977) Epidermal Langerhans cells express Ia antigens. Nature 268:248–250

    Article  Google Scholar 

  • Kasiske B (1987) Relationship between vascular disease and age-associated changes in the human kidney. Kidney Int 31:1153–1159

    Article  CAS  Google Scholar 

  • Kassianides C, Nussenblatt R, Palestine AG, Mellow SD, Hoofnagle JH (1990) Liver injury from cyclosporine A. Digest Dis Sci 35(6):693–697

    Article  CAS  Google Scholar 

  • Kato N, Yoshida A (1980) Effect of dietary PCB on hepatic cholesterogenesis in rats. Nutr Rep Int 21:107–112

    CAS  Google Scholar 

  • Kelly RI, Pearse R, Bull RH, Leveque JL, de Rigal J, Mortimer PS (1995) The effects of aging on the cutaneous microvasculature. J Am Acad Dermatol 33:749–756

    Article  CAS  Google Scholar 

  • Kinirons MT, O’Mahony MS (2004) Drug metabolism and aging. Br J Clin Pharmacol 57(5): 540–544

    Article  CAS  Google Scholar 

  • Kipen HM, Cody RP, Goldstein BD (1989) Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure. Environ Health Perspect 82:199–206

    Article  CAS  Google Scholar 

  • Kirschmann DA, Murasko DM (1992) Splenic and inguinal lymph node T-cells of aged mice respond differently to polyclonal and antigen-specific stimuli. Cell Immunol 139:426–437

    Article  CAS  Google Scholar 

  • Klaassen CD (2001) Casarett & Doull’s toxicology, the basic science of poisons. McGraw-Hill, New York, NY, pp 417–438

    Google Scholar 

  • Kline GH, Hayden TA, Klinman NR (1999) B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol 162:3342–3349

    CAS  Google Scholar 

  • Kochi S, Takanaga H, Matsuo H, Ohtani H, Naito M, Tsuruo T, Sawada Y (2000) Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and Tacrolimus. Life Sci 66:2255–2260

    Article  CAS  Google Scholar 

  • Koller LD (1977) Enhanced polychlorinated biphenyl lesions in Moloney leukemia virus-infected mice. Clin Toxicol 11:107–116

    Article  CAS  Google Scholar 

  • Kotsonis FN, Klaassen CD (1978) The relationship of metallothionein to the toxicity of cadmium after prolonged administration to rats. Toxicol Appl Pharmacol 46:39–54

    Article  CAS  Google Scholar 

  • Kowalski TE, Falestiny M, Furthe E, Malet PF (1994) Vitamin A hepatotoxicity: a cautionary note regarding 25,000 IU supplements. Am J Med 97(6):523–528

    Article  CAS  Google Scholar 

  • Kradjan WA, Driesner NK, Abuan TH, Emmick G, Schoene RB (1992) Effect of age on bronchodilator response. Chest 101:1545–1551

    Article  CAS  Google Scholar 

  • Kronenberg RS, Drage CW (1973) Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 53:1812–1819

    Article  Google Scholar 

  • Kreutler PA, Varbanov V, Goodman W, Olaya G, Stanbury JB (1978) Interactions of protein deficiency, cyanide, and thiocyanate on thyroid function in neonatal and adult rats. Am J Clin Nutr 31:282–289

    CAS  Google Scholar 

  • Krzystyniak K, Hugo P, Flipo D, Fournier M (1985) Increased susceptibility to mouse hepatitis virus 3 of peritoneal macrophages exposed to dieldrin. Toxicol Appl Pharmacol 80:397–408

    Article  CAS  Google Scholar 

  • Kumar V, Abbas AK, Fausto N (eds) (2005) Robins and Cotran pathologic basis of disease, 7th edn. Elsevier, Philadelphia, PA, p 706

    Google Scholar 

  • Labat-Robert J, Kern P, Robert L (1992) Biomarkers of connective tissue aging: biosynthesis of fibronectin, collagen type II and elastase. Ann NY Acad Sci 673:116–122

    Article  Google Scholar 

  • Lakatta EG (1993) Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73:413

    CAS  Google Scholar 

  • Lam CSP, Borlaug BA, Kane GC, Enders FT, Rodeheffer RJ, Redfield MM (2009) Age-associated increases in pulmonary artery systolic pressure in the general population. Circulation 119:2663–2670

    Article  Google Scholar 

  • Lange P, Schnohr P (2007) The relationship between facial wrinkling and airway obstruction. Int J Dermatol 33(2):123–126

    Article  Google Scholar 

  • Leape LL, Begrnnan TA, Laird N (1991) The nature of adverse events in hospitalized patients: results of the Harvard Medical Practice Study II. N Engl J Med 324:377–384

    Article  CAS  Google Scholar 

  • Lee CC, Bhandari JC, Winston JM, House WB (1977) Inhalation toxicity of vinyl chloride and vinylidene chloride. Environ Health Perspect 21:25–32

    CAS  Google Scholar 

  • Leitolf H, Behrends J, Braband G (2002) The thyroid axis in aging. In: Chadwick DJ, Goode JA (eds) Novartis foundation symposium 242 – endocrine facets of aging. John Wiley and Sons, Chichester, UK ISBN 9780471486367

    Google Scholar 

  • Lemaoult J, Szabo P, Weksler ME (1997) Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev 160:115–126

    Article  CAS  Google Scholar 

  • Le Page C, Noirez P, Courty J, Riou B, Swynghedauw B, Besse S (2009) Exercise training improves functional post-ischemic recovery in senescent heart. Exp Gerontol 44:177–182

    Article  Google Scholar 

  • Lesser PB, Vietti MM, Clark WD (1985) Lethal enhancement of therapeutic doses of acetaminophen by alcohol. Digest Dis Sci 32(1):193–195

    Google Scholar 

  • Leuenberger N, Pradervand S, Wahli W (2009) Sumolyated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest. doi: 10.1172/JCI39019

    Google Scholar 

  • Levin-Scherz JK, Patrick JD, Weber FH, Garabeedian C Jr (1987) Acute arsenic ingestion. Ann Emerg Med 16(6):702–704

    Article  CAS  Google Scholar 

  • Lewis J, Zimmerman H (1999) Drug- and chemical-induced cholestasis. Clin Liver Dis 3(3): 433–464

    Article  CAS  Google Scholar 

  • Li L, Mac-Mary S, Marsaut D, Sainthiller JM, Nouveau S, Gharbi J, de Lacharriere O, Humbert P (2006) Age-related changes in skin topography and microcirculation. Arch Dermatol Res 297:412–416

    Article  Google Scholar 

  • Li RW, Edwards MH, Brown B (2001) Variation in vernier evoked cortical potential with age. Invest Ophthalmol Vis Sci 42:1119–1124

    CAS  Google Scholar 

  • Li GL , Yin SN, Watanabe T, Nakatsuka H, Kasahara M, Abe H, Ikeda M (1986) Benzene-specific increase in leukocyte alkaline phosphatase activity in rats exposed to vapors of various organic solvents. J Toxicol Environ Health 19:581–589

    Article  CAS  Google Scholar 

  • Licht H, Seeff LB, Zimmerman HJ (1980) Apparent potentiation of acetaminophen hepatotoxicity by alcohol. Ann Inter Med 92(4):511

    CAS  Google Scholar 

  • Lieber CS, DeCarli LM (1976) Animal models of ethanol dependence and liver injury in rats and baboons. Fed Proc 35:1232–1236

    CAS  Google Scholar 

  • Lieber CS, Jones DP, DeCarli LM (1965) Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 44:1009–1021

    Article  CAS  Google Scholar 

  • Lin W-Q, White, KL (1993) Production of complement component C3 in vivo following 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. J Toxicol Environ Health 39:273–285

    Article  CAS  Google Scholar 

  • Lindeman RD (1993) Renal physiology and pathophysiology of aging. Contrib Nephrol 105: 1–12

    CAS  Google Scholar 

  • Lindeman RD, Preuss HG (1994) Renal physiology and pathophysiology of aging. Geriatr Nephrol Urol 4:113–120

    Article  Google Scholar 

  • Lindeman RD, Tobin JD, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33:278–285

    CAS  Google Scholar 

  • Linjakumpu, T, Hartikainen S, Klaukka T, Veijola J, Kivela S-L, Isoaho R (2002) Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol 55(8):809–817

    Article  Google Scholar 

  • Linton PJ, Haynes L, Klinman NR, Swain SL (1996) Antigen-independent changes in naïve CD4 T cells with aging. J Exp Med 184:1891–1900

    Article  CAS  Google Scholar 

  • Lipschitz DA, Udupa KB, Milton KY, Thompson CO (1984) Effect of age on hematopoiesis in man. Blood 63:502–509

    CAS  Google Scholar 

  • Litterst CL, Rarber TM, Baker AM, Van Loon EJ (1972) Effects of polychlorinated biphenyls on hepatic microsomal enzymes in the rat. Toxicol Appl Pharmacol 23:112–122

    Article  CAS  Google Scholar 

  • Longcope C, Jaffee W, Griffing G (1980) Metabolic clearance rates of androgens and oestrogens in aging women. Maturity 2(4):283–290

    Article  CAS  Google Scholar 

  • Loose LD, Silkworth JB, Charbonneau T, Blumenstock F (1981) Environmental chemical-induced macrophage dysfunction. Environ Health Perspect 39:79–92

    Article  CAS  Google Scholar 

  • Lopez-Novoa JM (2008) The mechanisms of age-associated glomerular sclerosis. In: Machas JF, Cameron JS, Oreopoulos DG (eds) The aging kidney in health and disease. Springer, New York, NY, pp 113–126

    Chapter  Google Scholar 

  • Lord JM, Butcher S, Killampali V, Lascelles D, Salmon M (2001) Neutrophil ageing and immunosenescence. Mech Ageing Dev 122:1521–1535

    Article  CAS  Google Scholar 

  • Macefield G, Gandevia SC, Burke D (1989) Conduction velocities of muscle and cutaneous afferents in the upper and lower limbs of human subjects. Brain 112(6):1519–1532

    Article  Google Scholar 

  • Mahler DA, Rosiella RA, Loke J (1986) The aging ling. Geriatr Clin North Am 2:215–225

    CAS  Google Scholar 

  • Makrantonaki E, Zouboulis CC (2007) The skin as a mirror of the aging process in the human organism – State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2). Exper Gerontol 42(9):879–886

    Article  CAS  Google Scholar 

  • Malave I, de Ruffino DT (1984) Altered immune response during cadmium administration in mice. Toxicol Appl Pharmacol 74:46–56

    Article  CAS  Google Scholar 

  • Mallya KB, Mendis T, Guberman A (1986) Bilateral facial paralysis following ethylene glycol ingestion. Can J Neurol Sci 13(4):340–341

    CAS  Google Scholar 

  • Maltoni C, Lefemine P, Cotti G, Patella V (eds) (1985) Experimental research on vinylidine chloride carcinogenesis: archives of research on industrial carcinogenesis, vol 3. Princeton Scientific, Princeton, NJ, p 229

    Google Scholar 

  • Marchesini G, Bua V, Brunori A, Bianchi G, Ppisi P, Fabbri A, Zoli M, Pisi E (1988) Galactose elimination capacity and liver volume in ageing man. Hepatology 8:1079–1083

    Article  CAS  Google Scholar 

  • Mariotti S, Franceschi C, Cossarizza A, Pinchera A (1995) The aging thyroid. Endocr Rev 16(6):686–715

    CAS  Google Scholar 

  • Marley SB, Lewis JL, Davidson RJ, Roberts IAG, Dokal I, Goldman JM, Gordon MY (1999) Evidence for a continuous decline in haemopoietic cell function from birth: application to evaluating bone marrow failure in children. Br J Haematol 106:162–166

    Article  CAS  Google Scholar 

  • Massey LK. (1998) Caffeine and the elderly. Drug Aging 13:45–50

    Article  Google Scholar 

  • Massey LK, Whiting SJ (1993) Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 123:1611–1614

    CAS  Google Scholar 

  • McCauley PT, Robinson M, Condie LW, Parvell M (1990) The effect of subacute and subchronic oral exposure to cis-1,2-dichloroethylene in rats. Environmental Protection Agency, Health Effects Research Laboratory, Cincinnati, OH, and Air Force Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH

    Google Scholar 

  • McConnel EE, Moore JA, Dalgard DW (1978) Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rhesus monkeys (Macaca mulatta) following a single oral dose. Toxicol Appl Pharmacol 43:175–187

    Article  Google Scholar 

  • McCullough JL, Kelly KM (2006) Prevention and treatment of skin aging. Ann NY Acad Sci 1067:323–331

    Article  Google Scholar 

  • McKenna MJ, Zempel JA, Madrid EO, Gehring PJ (1978) The pharmacokinetics of [14C] vinylidine chloride in rats following inhalation exposure. Toxicol Appl Pharmacol 45:599–610

    Article  CAS  Google Scholar 

  • McLean AJ, Le Couteur DG (2004) Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56:163–184

    Article  CAS  Google Scholar 

  • Mege JL, Capo C, Michel B, Gastaut JL, Bongrand P (1988) Phagocytic cell function in aged subjects. Neurobiol Aging 9:217–220

    Article  CAS  Google Scholar 

  • Meier-Ruge W, Ulrich J, Bruhlmann N, Meier E (1992) Age-related white matter atrophy in the human brain. Ann NY Acad Sci 673:260–269

    Article  CAS  Google Scholar 

  • Milberg JA, Davis DR, Steinberg KP, Hudson LD (1995) Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983–1993. JAMA 273:306–309

    Article  CAS  Google Scholar 

  • Milla P (2002) Children are not just little adults. Clin Nutr 21(Suppl 1):1370139

    Google Scholar 

  • Miller RA (1996) The aging immune system: primer and prospectus. Science 273:70–74

    Article  CAS  Google Scholar 

  • Miller C, Kelsoe G, Han S (1994) Lack of B7-2 expression in the germinal centers of aged mice. Aging Immunol Infect Dis 5:249–257

    Google Scholar 

  • Minuk GY, Kelly JK, Hwang W-S (1987) Vitamin A hepatotoxicity in multiple family members. Hepatology 8(2):272–275

    Article  Google Scholar 

  • Mittman C, Edelman NH, Norris AH, Shuck NW (1965) Relationship between chest wall and pulmonary compliance and age. J Appl Physiol 20:1211–1216

    Google Scholar 

  • Mocchegiani E, Malavolta M (2004) NK and NKT cell functions in immunosenescence. Aging Cell 2004:177–184

    Article  CAS  Google Scholar 

  • Monette J, Gurwitz JH, Avorn J (1995) Epidemiology of adverse drug events in the nursing home setting. Drugs Aging 7(3):203–211

    Article  CAS  Google Scholar 

  • Montagna W, Carlisle K (1979) Structural damages in aging human skin. J Invest Dermatol 73:74

    Article  Google Scholar 

  • Mooradian AD (1992) Geriatric Neuroendocrinology. In: Nemeroff CB( ed) Neuroendocrinology. CRC Press, Boca Raton, FL, pp 541–562

    Google Scholar 

  • Moore FA, Sauaia A, Moore EE, Haenel JB, Burch JM, Lezotte DC (1996) Postinjury multiple organ failure: bimodal phenomenon. J Trauma 0:5011–510

    Google Scholar 

  • Morely JE, Reece SS (1989) Clinical implications of the aging heart. Am J Med 86:77–86

    Article  Google Scholar 

  • Moragas A, Castells C, Sans M (1993) Mathematical morphologic analysis of aging-related epidermal changes. Anal Quant Cytol Histol 15:75–82

    CAS  Google Scholar 

  • Morely JE, Kaiser FE, Merry HMI, Patrick P, Morely PM, Stauber PM, Vellas B, Baumgartner RN, Garry PJ (1997) Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 46(4):410–413

    Article  Google Scholar 

  • Morris JS, Schmidt M, Newman S, Schever PG, Sherlock S (1974) Arsenic and noncirrhotic portal hypertension. Gastroenterology 66(1):86–94

    CAS  Google Scholar 

  • Moscicki EK, Elkins HM, McNamara PM (1985) Hearing loss in the elderly: an epidemiologic study of the Framingham Heart Study Cohort. Ear Hear 6(4):184–190

    Article  CAS  Google Scholar 

  • Muravchick S (1996) Anesthesia for the geriatric patient. In: Barfash PG (ed) Clinical anesthesia. Lippincott-Raven, Philadelphia, PA, pp 1131–1133

    Google Scholar 

  • Mulligen T, Iranmanesh A, Johnson ML, Straume MJD (1997) Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men. Am J Physiol 273(4. pt. 2):R1407–1413

    Google Scholar 

  • Murakami S, Nasu M, Fukayama H, Krishnam L, Sugawara M (2004) Propranolol has direct antithyroid activity: Inhibition of iodide transport in cultured thyroid follicles. Cell Biochem Funct 11(3):159–165

    Article  Google Scholar 

  • Murasko DM, Dernstein ED, Gardner EM, Gross P, Munk G, Dran S, Abrutyn E (2002) Role of humoral and cell-mediated immunity in protection from influenza 33 disease after immunization of healthy elderly. Exp Gerontol 37(2–3):427–439

    Article  CAS  Google Scholar 

  • Murray MD, Brater DC (1993) Renal toxicity of the nonsteroidal anti-inflammatory drugs. Ann Rev Pharmacol Toxicol 32:435–465

    Google Scholar 

  • Murray FJ, Smith FA, Nitschke KD, Humiston CG, Kociba RJ, Schwetz BA (1979) Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol Appl Pharmacol 50:241–251

    Article  CAS  Google Scholar 

  • Nagahiro S, Yamamoto YL, Diksic M, Mitsuka S, Sugimoto S, Feindel W (1991) Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography. Neurosurgery 29:19–25

    Article  CAS  Google Scholar 

  • Nagaratnam N, Ip J, Bou-Haidar P (2005) The vestibular dysfunction and anxiety disorder interface: a descriptive study with special reference to the elderly. Arch Geront Geriatr 40:253–264

    Article  Google Scholar 

  • NAS (2005) National Academies of Science. Health implications of perchlorate ingestion. Board on environmental studies and toxicology (BEST). Appendix D – Sensitivity of perchlorate induced iodide uptake inhibition to serum iodide concentrations. The National Academies Press, pp 216–220

    Google Scholar 

  • Naylor K, Li G, Vallejo AN, Won-Woo L, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ (2005) The influence of age on T cell generation and TCR diversity. J Immunol 174:7446–7452

    CAS  Google Scholar 

  • Neugarten J, Gallo G, Silbiger S, Kasiske B (1999) Glomerulosclerosis in aging humans is not influenced by gender. Am J Kidney Dis 34(5):884–888

    Article  CAS  Google Scholar 

  • Ng Y, Goldspink DF, Burniston JG, Clark WA, Colyer J, Tan L-B (2002) Characterization of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle. Int J Cardiol 86: 299–309

    Article  Google Scholar 

  • Nichols WW, O’Rourke MF (1998) Aging. In: Nichols WWW, O’Rourke MF (eds) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles. Oxford University Press, New York, NY, pp 355–358

    Google Scholar 

  • Nordin BEC, Need AG, Morris HA, O’Loughlin PD, Horowitz M (2004) Effect of age on calcium absorption in post-menopausal women. Am J Clin Nutr 80:998–1002

    CAS  Google Scholar 

  • NRC (1987) Work, aging, and vision. Report of a Conference. National Research Council, National Academy Press, Washington, DC

    Google Scholar 

  • NTP (1993) Toxicology and carcinogenesis studies of mercuric chloride (CAS no. 7487-94-7) in F344/N rats and B6C3F1 mice (gavage studies). ational Toxicology Program, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC. NTP TR 408. NIH publication no. 91-3139

    Google Scholar 

  • NTP (1985a) Toxicology and carcinogenesis studies of chlorobenzene (CAS No. 108-90-70) in F344/N rats and B6C3F mice (gavage studies). Technical report series no. 261. Research Triangle Park, NC. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Toxicology Program. NIH publication no. 86-2517

    Google Scholar 

  • NTP (1985b) Toxicology and carcinogenesis studies of 1,2-dichlorobenzene (o-dichlorobenzene) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC. National Toxicology Program. NTP TR255. NIH publication no. 86-2511

    Google Scholar 

  • Nunez C, Nishimoto N, Grland GL, Billips LG, Burrows PD, Kubagawa H, Cooper MD (1996) B cells are generated throughout life in humans. J Immunol 156:866–872

    CAS  Google Scholar 

  • Oddie TH, Meade JH Jr, Fisher DA (1966) An analysis of published data on thyroxine turnover in human subjects. J Clin Endocrinol Metab 26(4):425–436

    Article  CAS  Google Scholar 

  • Ogawa T, Kitagawa M, Hirokawa K (2000) Age-related changes of human bone marrow: a histometric estimation of proliferative dells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev 117:57–68

    Article  CAS  Google Scholar 

  • Ohsawa M, Takahashi K, Otsuka F (1988) Induction of anti-nuclear antibodies in mice orally exposed to cadmium at low concentrations. Clin Exp Immunol 73:98–102

    CAS  Google Scholar 

  • Oliver P, Bertrand L, Tubery M, Lauque D, Montastruc J-L, Layeyre-Mestre M (2009) Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department. Drugs Aging 26(6):475–482

    Article  Google Scholar 

  • Olivetti G, Melissari M, Capasso JM, Anversa P (1991) Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res 68:1560–1568

    Article  CAS  Google Scholar 

  • Orentreich N, Brind JL, Rizer RL, Vogelman JH (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59(3):551–555

    Article  CAS  Google Scholar 

  • Orwoll E, Nielson CM, Marshall LM, Lambert L, Holton KF, Hoffman AR, Barrett-Connor E, Shikany JM, Dam T, Cauley JA (2009) Vitamin D deficiency in older men. J Clin Endocrinol Metab 94:1214–1222

    Article  CAS  Google Scholar 

  • O’Shea J (1997) Jaks, STATs, cytokine signal review, transduction, and immunoregulation: are we there yet? Immunity 7:1–11

    Article  Google Scholar 

  • Oskvig RM (1999) Special problems in the elderly. Chest 115:158S–164S

    Article  CAS  Google Scholar 

  • Park SK, Prolla TA (2005) Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res Rev 4:55–65

    Article  CAS  Google Scholar 

  • Parker BM, Cusack BJ, Vestal RE (1995) Pharmacokinetic optimisation of drug therapy in elderly patients. Drugs Aging 7:10–18

    Article  Google Scholar 

  • Partridge L, Mangel M (1999) Messages from mortality: the evolution of death rates in the old. Trends Ecol Evol 14(11):438–442

    Article  Google Scholar 

  • Pawelec G, Rehbein A, Haehnel K, Meri A. Adibzadeh M (1997) Human T cell clones as a model of immunosenescence. Immunol Rev 160:31–43

    Article  CAS  Google Scholar 

  • Pawelec G, Solana R, Remarque E, Mariani E (1998) Impact of aging on innate immunity. J Leuko Biol 6:703–712

    Google Scholar 

  • PDR (Physicians’ Desk Reference) (2007) Physicians’ desk reference, 61st edn. Medical Economics, Montvale, NJ, p 3153

    Google Scholar 

  • Pearce D, Bonnet D (2009) Ageing within the hematopoietic stem cell compartment. Mech Ageing Dev 130:54–57

    Article  CAS  Google Scholar 

  • Penumarthy L, Oehme FW (1975) Treatment of ethylene glycol toxicosis in cats. Am J Vet Res 36(2):209–212

    CAS  Google Scholar 

  • Perl DP, Gajdusek DC, Garruto RM, Yanagihara RY, Gibbs CJ (1980) Intraneuronal aluminum encephalopathy. Acta Neuropathol 50:19–24

    Article  Google Scholar 

  • Perry HM III (1999) The endocrinology of aging. Clin Chem 45(8B):1369–1376

    CAS  Google Scholar 

  • Pfefferbaum A, Mathalson DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO (1994) A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 51(9):874–887

    Article  CAS  Google Scholar 

  • Pochi JS, Strauss JS, Downing DT (1979) Age-related changes in sebaceous gland activity. J Invest Dermatol 73:106–111

    Article  Google Scholar 

  • Poligano A, Tortorella C, Venezia A, Jirillo E, Antonaci S (1994) Age-associated changes of neutrophil responsiveness in a human healthy elderly population. Cytobios 80:145–153

    Google Scholar 

  • Pontoppidan H, Beecher HK (1960) Progressive loss of protective reflexes in the airway with advanced age. JAMA 2209–2213

    Google Scholar 

  • Price SC, Ozalp S, Weaver R, Chescoe D, Mullervy J, Hinton RH (1988) The thyroid hyperactivity caused by hypolipodaemic compounds and polychlorinated biphenyls: the effect of coadministration in the liver and thyroid. Arch Toxicol Suppl 12:85–92

    Article  CAS  Google Scholar 

  • Prigge E (1978) Early signs of oral and inhalative cadmium uptake in rats. Arch Toxicol 40: 231–247

    Article  CAS  Google Scholar 

  • Priox J, Romonatxo M, Hayot M, Mucci P, Prefaut C (2000) Effect of aging on the ventilatory response and lactate kinetics during incremental exercise in man. Eur J Appl Physiol 81(1–2):100–107

    Article  Google Scholar 

  • Proudlock FA, Shekhar H, Gottlob I (2004) Age-related changes in head and eye coordination. Neurobiol Aging 25:1377–1385

    Article  Google Scholar 

  • Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, Lindau ST (2008) Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 300(24):2867–2878

    Article  CAS  Google Scholar 

  • Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL, Sauder DN (2006) Photoaging: mechanisms and repair. J Am Acad Dermatol 55:1–19

    Article  Google Scholar 

  • Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL (2001) Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 74:694–700

    CAS  Google Scholar 

  • Ravelojaona V, Robert L, Robert A-M (2008) Effect of cellular aging on collagen biosynthesis II. Collagen synthesis and deposition by a human skin fibroblast strain over 25 passages. Arch Gerontol Geriatr 47:368–376

    Article  CAS  Google Scholar 

  • Raz N, Gunning FM, Head D, Dupuis, JH, McQuain J, Briggs SD, Thornton AE, Loken WJ, Acker JD (1997) Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 7:268–282

    Article  CAS  Google Scholar 

  • Reenstra WR, Yaar M, Gilchrest BA (1996) Aging affects epidermal growth factor receptor phosphorylation and traffic kinetics. Exp Cell Res 227:252–255

    Article  CAS  Google Scholar 

  • Rego EM, Garcia AB, Viana SR, Falcao RP (1998) Age-related changes of lymphocyte subsets in normal bone marrow biopsies. Cytometry 34:22–29

    Article  CAS  Google Scholar 

  • Reidenberg MM (1982) Drug interactions and the elderly. J Am Geriatr Soc 30:567–568

    Google Scholar 

  • Riachi NJ, Behmand RA, Harik SI (1991) Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood–brain barrier in vitro in five rat strains. Rain Res 555:19–24

    Article  CAS  Google Scholar 

  • Rieser C, Papesh C, Herold M, Bock G, Ramoner R, Klocker JH, Bartsch G, Thurnher M (1998) Differential deactivation of human dendritic cells by endotoxin desensitization: role of tumor necrosis factor-alpha and prostaglandin E2. Blood 91:3112–3117

    CAS  Google Scholar 

  • Riggs BL, Melton LJI (1986) Involutional osteoporosis. N Engl J Med 314(26):1676–1686

    Article  CAS  Google Scholar 

  • Risher JF, De Rosa CT (1997) The precision and limitations of health guidance values. Hum Ecol Risk Assess 3(5):681–700

    Article  Google Scholar 

  • Roberts-Thompson IC, Yuonscaiyud V, Whittingham S (1974) Aging, immune response and mortality. Lancet II:368–370

    Article  Google Scholar 

  • Robinson SN, Shah R, Wong BA, Wong VA, Farris GM (1997) Immunotoxicological effects of benzene inhalation in male Sprague-Dawley rats. Toxicology 119(3):227–237

    Article  CAS  Google Scholar 

  • Rodriguez GL, Larbarthe DR, Huang B, Lopez-Gomez J (1994) Rise in blood pressure with age: new evidence of population differences. Hypertension 24:779–785

    Article  CAS  Google Scholar 

  • Romero IA, Ray DE, Chan MW, Abbott NJ (1996) An in vitro study of m-dinitrobenzene toxicity on the cellular components of the blood–brain barrier, astrocytes and endothelial cells. Toxicol Appl Pharmacol 139:94–101

    Article  CAS  Google Scholar 

  • Rothschild JM, Bates DW, Leape LL (2000) Preventable medical injuries in older patients. Arch Intern Med 160:2717–2728

    Article  CAS  Google Scholar 

  • Rowden G, Lewis MG, Sullivan AK (1977) Ia antigen expression on human epidermal Langerhans cells. Nature 268:247–248

    Article  CAS  Google Scholar 

  • Ruby CM, Hanlon JT, Fillenbaum GG, Pieper CF, Branch LG, Bump RC (2005) Medication use and control of urination among community-dwelling older adults. J Aging Health 17(5): 661–674

    Article  Google Scholar 

  • Ruscetti FW, Keller JR, Longo DL (1998) Chapter 105: Hematopoiesis. In Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL (eds) Harrison’s principles of internal medicine, 14th edn. McGraw-Hill Medical, New York, NY, p 624

    Google Scholar 

  • Russel-Aulet M, Jaffe CA, Mott-Friberg R, Barkan AL (1999) In vivo semiquantification of hypothalamic growth-hormone-releasing hormone (GHRH) output in humans: evidence for relative GNRH deficiency in aging. J Clin Endocrinol Metab 84(10):3490–3497

    Article  Google Scholar 

  • Sabbieti MG, Agas D, Sontoni G, Materazzi S, Menghi G, Marchetti L (2009) Involvement of p53 in phthalate effects on mouse and rat osteoblasts. J Cell Biochem 107:316–327

    Article  CAS  Google Scholar 

  • Salat DH, Tuch DS, Greve DN, vaan derr Kouwe AJ, Hevelone ND, Zelata AK, Rosen BR, Fischl B, Corkin S, Rosas HD, Dale AM (2005) Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging 26:1215–1227

    Article  CAS  Google Scholar 

  • Sampson HW (2002) Alcohol and other factors affecting osteoporosis risk in women. Alcohol Res Health 26(4):292–298

    Google Scholar 

  • Sauder DN (1986) Effect of age on epidermal immune function. Dermatol Clin 4:447

    CAS  Google Scholar 

  • Saurwein-Teissl M, Lung TL, Marx F, Gschosser C, Asch E, Blasko I, Parson W, Bock G, Schonitzer D, Trannoy E, Grubeck-Loebenstein B (2002) Lack of antibody production following immunization in old age: association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 168(11):5893–5899

    CAS  Google Scholar 

  • Schiffman SS (2007) Critical illness and changes in sensory perception. Proc Nutr Soc 66:331–345

    Article  Google Scholar 

  • Schiffman SS, Rogers MO, Zervakis J (2003) Loss of taste, smell, and other senses with age: effects of medication. In: Bales CW, Ritchie CS (ed) Handbook of clinical nutrition and aging. Humana Press, Totowa, NG, pp 211–289

    Google Scholar 

  • Seeman TE, McEwen BS, Singer BH, Albert MS, Rowe JW (1997) Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J Clin Endocrinol Metab 82(8):2458–2465

    Article  CAS  Google Scholar 

  • Serot JM, Christmann D, Dubost T, Couturier M (1997) Cerebrospinal fluid transthyretin: aging and late onset Alzheimer’s disease. J Neurol Neurosurg Policy 63:506–508

    Article  CAS  Google Scholar 

  • Shah GN, Mooradian AD (1997) Age-related changes in the blood–brain barrier. Exper Gerontol 32(4, 5):501–519

    Article  CAS  Google Scholar 

  • Sharkey JR, Browne B, Ory MG, Wang S (2005) Patterns of therapeutic prescription medication category use among community-dwelling homebound older adults. Pharmacoepidemiol Drug Saf 14(10):715–723

    Article  Google Scholar 

  • Shiraha H, Gupta K, Drabik K, Wells A (2000) Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. J Biol Chem 275(25):19343–19351

    Article  CAS  Google Scholar 

  • Shiwin C, Lin Y, Zhineng H, Xianzu, Zhaolu Y, Huidong X (1990) Cadmium exposure and health effects among residents in an irrigation area with ore dressing wastewater. Sci Total Environ 90:67–73

    Article  Google Scholar 

  • Sherman BM, West JH, Korenman SG (1976) The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab 42(4):629–636

    Article  CAS  Google Scholar 

  • Siew S, Matta RK, Johnson M (1975) Investigation of “crystallosis” in ethylene glycol. Toxicity. Scan Electron Microsc 8:555–562

    CAS  Google Scholar 

  • Silkworth JB, Cutler DS, Sack GG (1989) Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a complex environmental mixture from the Love Canal. Fundam Appl Toxicol 12:303–312

    Article  CAS  Google Scholar 

  • Sinclair J, Jeffery E, Wrighton S, Kostrubsky V, Szakacs J, Wood S (1998) Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Biochem Pharmacol 55(10):1557–1565

    Article  CAS  Google Scholar 

  • Slikker W, Vore M, Bailey JR, Meyers M, Montgomery C (1983) Hepatotoxic effects of estradiol-17 beta-D-glucuronide in the rat and monkey. Pharmacol Exp Ther 225(1):138–143

    CAS  Google Scholar 

  • Smialowicz RJ, Andrews JE, Riddle MM, Rogers RR, Luebke RW, Copeland CB (1989) Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology 56:197–211

    Article  CAS  Google Scholar 

  • Smith JB, Fenske NA (1996) Cutaneous manifestations and consequences of smoking. J Am Acad Dermatol 34(5 Pt 1):717–732

    CAS  Google Scholar 

  • Snyder Ca, Sellakumar AR, James DJ, Albert RE (1988) The carcinogenicity of discontinuous inhaled benzene exposures in CD-1 and C57BL/6 mice. Arch Toxicol 62:331–335

    Article  CAS  Google Scholar 

  • Snyder CA, Bernstein BD, Sellakumar A (1984) Evidence for hematotoxicity and tumorigenesis in rats exposed to 100 ppm benzene. Am J Ind Med 5:429–434

    Article  CAS  Google Scholar 

  • Snyder CA, Goldstein BD, Sellakumar AR, Bromberg I, Laskin S, Albert RE (1980) The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57BL/6 J mice. Toxicol Appl Pharmacol 54:323–331

    Article  CAS  Google Scholar 

  • Snyder CA, Goldstein BD, Sellakamur A, Wolman S, Bromberg I, Erlichman MN, Laskin S (1978) Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 ppm. J Toxicol Environ Health 4:605–618

    Article  Google Scholar 

  • Spearman ME, Leibman KG (1984) Effects of aging on hepatic and pulmonary glutathione S-transferase activities in male and females Fischer 344 rats. Biochem Pharmacol 33(8):1309–1313

    Article  CAS  Google Scholar 

  • Speroff L, Glass RH, Kase NG (eds) (1999) Clinical gynecologic endocrinology and infertility, 6th edn. Lippincott Williams and Wilkins, Baltimore, MD

    Google Scholar 

  • Steele AC, Kohli N, Mallipeddi P, Karram M (1999) Pharmacologic causes of female incontinence. Intern J Urogynocol 10:106–110

    Article  CAS  Google Scholar 

  • Steger M, Maczek C, Grubeckloebenstein B (1997) Peripheral blood dendritic cells reinduce proliferation in in vitro aged T-cell populations. Mech Ageing Dev 93:125–130

    Article  CAS  Google Scholar 

  • Steinmaus C, Miller MD, Howd R (2007) Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001–2002 National health and nutrition examination survey. Environ Health Perspect 1151(9):1333–1338

    Article  CAS  Google Scholar 

  • Stowe HD, Wilson M, Goyer RA (1972) Clinical and morphological effects of oral cadmium toxicity in rabbits. Arch Pathol 94:389–405

    CAS  Google Scholar 

  • Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 121:2005–2013

    CAS  Google Scholar 

  • Stratton JR, Levy WC, Cerqueira MD, Schwartz RS, Abrass IB (1994) Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men. Circulation 89:1648–1655

    Article  CAS  Google Scholar 

  • Strazielle N, Ghersi-Egea JF (1999) Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J Neurosci 19(15): 6275–6289

    CAS  Google Scholar 

  • Street JC, Sharma RP (1975) Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, Aroclor 1254, carbaryl, carbofuran, and methyl parathion. Toxicol Appl Pharmacol 32:587–602

    Article  CAS  Google Scholar 

  • Swift ME, Burns AL, Gray KL, DiPietro LA (2001) Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 117:1027–1035

    Article  CAS  Google Scholar 

  • Swift CG, Homeida M, Halliwell M, Roberts CJC (1984) Antipyrine disposition and liver size in elderly. Eur J Clin Pharmacol 14:149–151

    Article  Google Scholar 

  • Syntichaki P, Tavernarakis N (2006) Signaling pathways regulating protein synthesis during ageing. Exp Gerontol 41:1020–1025

    Article  CAS  Google Scholar 

  • Szakal AK, Taylor JK, Smith JP, Kosco MK, Burton GF, Tew JG (1988) Morphometry and kinetics of antigen transport and developing antigen retaining reticulum of follicular dendritic cells in lymph nodes of aging immune mice. Aging Immunol Infect Dis 1:7–22

    Google Scholar 

  • Szumanska G, Gadamski R, Albrecht J (1993) Changes of the Na/K ATPase activity in the cerebral cortical microvessels of rat after single intraperitoneal administration of mercuric chloride: histochemical demonstration with light and electron microscopy. Acta Neuropathol 86: 65–70

    Article  CAS  Google Scholar 

  • Takafumi O, Kitagawa M, Hirokawa K (2000) Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev 117:57–68

    Article  Google Scholar 

  • Tan L-B, Littler WA (1990) Measurement of cardiac reserve in cardiogenic shock: implications for prognosis and management. Br Heart J 64:121–128

    Article  CAS  Google Scholar 

  • Tauchi H, Tsubol L, Okutomi J (1971) Age changes in the human kidney of the different races. Gerontologia 17:87–97

    Article  CAS  Google Scholar 

  • Tavernarakis N, Driscoll M (2002) Caloric restriction and lifespan: a role for protein turnover? Mech Ageing Dev 123:215–229

    Article  CAS  Google Scholar 

  • Thomas PT, Hinsdill RD (1978) Effect of polychlorinated biphenyls on the immune responses of Rhesus monkeys and mice. Toxicol Appl Pharmacol 44:41–51

    Article  CAS  Google Scholar 

  • Tiefenbach B, Lange P (1980) Studies on the action of dimethoate on the immune system. Arch Toxicol Suppl 4:167–170

    Article  CAS  Google Scholar 

  • Timaffy M (1962) A comparative study of bone marrow function in young and old individuals. Gerontol Clin 4:13–18

    Article  CAS  Google Scholar 

  • Toft K, Olofsson T, Tunek A, Berlin M (1982) Toxic effects on mouse bone marrow caused by inhalation of benzene. Arch Toxicol 51:295–302

    Article  CAS  Google Scholar 

  • Tolep K, Higgins N, Muza S, Criner G, Kelsen SG (1995) Comparison of diaphragm strength between healthy adult elderly. Am J Resp Crit Care Med 152(2):677–682

    CAS  Google Scholar 

  • Tolep K, Kelsen SG (1993) Effect of aging on respiratory skeletal muscles. Clin Chest Med 14(3):363–378

    CAS  Google Scholar 

  • Tonn T, Esser C, Schneider EM, Steinmann-Steiner-Haldenstätt W, Gleichmann E (1996) Persistence of decreased T-helper cell function in industrial workers 20 years after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 104:422–426

    Article  CAS  Google Scholar 

  • Truelove J, Grant D, Mes J, Trypnonas H, Tryphonas L, Zawidzka ZZ (1982) Polychlorinated biphenyl toxicity in the pregnant cynomolgus monkey: a pilot study. Arch Environ Contam Toxicol 11:583–588

    Article  CAS  Google Scholar 

  • Tryphonas H, Hayward S, O’Grady L, Loo JCK, Arnold DL, Bryce F, Zawidzka ZZ (1989) Immunotoxicity studies of PCB (Aroclor 1254) in adult Rhesus (Macaca mullata) monkey – Preliminary report. Int J Immunopharmacol 11:199–206

    Article  CAS  Google Scholar 

  • Turnheim K (1998) Drug dosage in the elderly: is it rational? Drugs Aging 13:357–379

    Article  CAS  Google Scholar 

  • Umbreit TH, Patel D, Gallo MA (1985) Acute toxicity of TCDD contaminated soil from an industrial site. Chemosphere 14:945–947

    Article  CAS  Google Scholar 

  • Van CE, Leproult R, Kupfer DJ (1996) Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 81(7):2468–2473

    Article  Google Scholar 

  • Van Birgelen APJM, Van der Kolk, J, Fase KM, Bol I, Polger H, Brouwer A, Vandenberg M (1995) Subchronic dose–response study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicol Appl Pharmacol 132:1–13

    Article  Google Scholar 

  • Van Sande J, Deneubourg F, Beauwens R, Braekman JC, Daloze D, Dumont JE (1990) Inhibition of iodide transport in thyroid cells by dysidenin, a marine toxin, and some of its analogs. Mol Pharmacol 37(4):583–589

    Google Scholar 

  • Varani J, Dame MK, Rittie L, Fligiel SEG, Kang S, Fisher GJ, Vorhees JJ (2006) Decreased collagen production in chronically aged skin. Am J Pathol 168(6):1861–1868

    Article  CAS  Google Scholar 

  • Vecchi AS, Sironi M, Canegrati MA, Recchia M, Garatini S (1983) Comparison of the immunosuppressive effects in mice of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran. In: Choudhary G, Keith LH, Rappe C (eds) Chlorinated dioxins and dibenzofurans in the total environment. Butterworth, Boston, MA, pp 397–402

    Google Scholar 

  • Veldhuis JD, Iranmanesh A, Bowers CY (2005) Joint mechanisms of impaired growth-hormone pulse renewal in aging men. J Clin Endocrinol Metab 9(7):4177–4183

    Article  CAS  Google Scholar 

  • Vermeulen A (2001) Androgen replacement therapy in the aging male – a critical evaluation. J Clin Endocrinol Metab 86(6):2380–2390

    Article  CAS  Google Scholar 

  • Vermeulen A (1995) Dehydroepiandrosterone sulfate and aging. Ann NY Acad Sci 774:121–127

    Article  CAS  Google Scholar 

  • Vetricka V, Tlaskolova-Hogenova H, Pospisil M (1985) Impaired antigen-presenting function of macrophages form aged mice. Immunol Invest 14:105–114

    Article  Google Scholar 

  • Viluksela M, Stahl BU, Rozman KK (1994) Subchronic (13-week) toxicity of heptachlorodibenzo-p-dioxin in male Sprague-Dawley rats. Chemosphere 29:2381–2393

    Article  CAS  Google Scholar 

  • Vos JG, Moore JA, Zinkl JG (1973) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ Health Perspect 5:149–162

    Article  CAS  Google Scholar 

  • Vos JG, de Roij T (1972) Immunosuppressive activity of a polychlorinated biphenyl preparation on the humoral immune response tin guinea pigs. Toxicol Appl Pharmacol 12:549–555

    Article  Google Scholar 

  • Vos JG, Van Dreil-Grootenhuis D (1972) PCBV-induced suppression of the humoral and cell-mediated immunity in guinea pigs. Sci Total Environ 1:289–302

    Article  CAS  Google Scholar 

  • Wagner W, Horn P, Bork S, Ho AD (2008) Aging of hematopoietic stem cells is regulated by the stem cell niche. Exp Gerontol 43:974–980

    Article  CAS  Google Scholar 

  • Waldmann TA (2006) The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immun 6(8):595–601

    Article  CAS  Google Scholar 

  • Waldmann TA, Tagaya Y (1999) The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Ann Rev Immunol 17:19–49

    Article  CAS  Google Scholar 

  • Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Dale AM, Eilertsen DE, DE, Quinn BT, Salat D (2005) Effects of age on volumes of cortex, white matter, and subcortical structures. Neurobiol Aging 26:1261–1270

    Article  Google Scholar 

  • Walker J, Wynne H (1994) Review: the frequency and severity of adverse drug interactions in elderly people. Age Aging 23(3):255

    Article  CAS  Google Scholar 

  • Walker RM, Racz WJ, McElligott TF (1983) Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice. Am J Pathol 113:321–330

    CAS  Google Scholar 

  • Ward CO, Kuna RA, Snyder NK, Alsaker RD, Coate WB, Craig PH (1985) Subchronic inhalation toxicity of benzene in rats and mice. Am J Ind Med 7:457–473

    Article  CAS  Google Scholar 

  • Ware JH, Dockery DW, Louis TA, Xu X, Ferris BG Jr, Speizer FE (1990) Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol 132:685–700

    CAS  Google Scholar 

  • Warfvinge K, Hansson H, Hultman P (1995) Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose–response studies. Toxicol Appl Pharmacol 132:299–309

    Article  CAS  Google Scholar 

  • Weksler ME, Hutteroth TH (1974) Impaired lymphocyte function in aged humans. J Clin Invest 53:99–104

    Article  CAS  Google Scholar 

  • Wells MS, Nerland DE (1991) Hematotoxicity and concentration-dependent conjugation of phenol in mice following inhalation exposure to benzene. Toxicol Lett 56(1–2):159–166

    Article  CAS  Google Scholar 

  • Westerhof N, O’RourkeMF (1995) Haemodynamic basis for development of left ventricular failure in systolic hypertension and for it logical therapy. J Hyperten 13:943–952

    Article  CAS  Google Scholar 

  • Westphal JF, Vetter D, Brogard JM (1994) Hepatic side-effects of antibiotics. J Antimibrob Chemother 33:387–401

    Article  CAS  Google Scholar 

  • White KL Jr, Lysy HH, McCay JA, Anderson AC (1986) Modulation of serum complement levels following exposure to polychlorinated dibenzo-p-dioxins. Toxicol Appl Pharmacol 84:209–219

    Article  CAS  Google Scholar 

  • WHO (2005) Children are not little adults. World Health Organization. Children’s Health and the Environment, WHO Training Package for the Health Sector. Geneva, Switzerland. Accessed 28/06/2005. http://www.who.int/ceh

  • Wicherts IS, van Schoor NM, Boeke AJP, Visser M, Deeg DJH, Smit J, Knol DL, Lips P (2007) Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 92(6):2058–2065

    Article  CAS  Google Scholar 

  • Wick G, Grubeck-Loebenstein B (1997) The aging immune system: primary and secondary alterations of immune reactivity in the elderly. Exp Gerontol 32(4–5):401–413

    Article  CAS  Google Scholar 

  • Wilcox SM, Himmelstein DU, Woolhandler S (1994) Inappropriate drug prescribing for the community-dwelling elderly. JAMA 272(4):292–296

    Article  Google Scholar 

  • Williamson J, Chopin JM (1980) Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Aging 9:73–80

    Article  CAS  Google Scholar 

  • Williams SG, Cooke GA, Wright DJ, Parsons WJ, Riley RL, Marshal P, Taqn L-B (2001) Peak exercise cardiac power outcome: a direct indicator of cardiac function strongly predictive of prognosis in chronic heart failure. Eur Heart J 22:1496–1503

    Article  CAS  Google Scholar 

  • Williams DA, Xu H, Cancelas JA (2006) Children are not little adults: just ask their hematopoietic stem cells. J Clin Invest 116(10):2593–2596

    Article  CAS  Google Scholar 

  • Wolf OT, Dziobek I, McHugh P, Sweat V, de Leon MJ, Javier E, Convit A (2005) Subjective memory complaints in aging are associated with elevated cortisol levels. Neurobiol Aging 26:1357–1363

    Article  CAS  Google Scholar 

  • Wolf MA, Rowe VK, McCollister DD, Hollingsworth RL, Oyen F (1956) Toxicological studies of certain alkylated benzenes and benzene. Arch Ind Health 14:387–398

    CAS  Google Scholar 

  • Wolfson L (2001) Gait and balance dysfunction: a model of the interaction of age and disease. Neuroscientist 7(2):178–183

    Article  CAS  Google Scholar 

  • Woodhouse KW, Wynne HA (1988) Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly. Clin Pharmacokinet 15:287–294

    Article  CAS  Google Scholar 

  • Woodhouse KW, Mutch E, Williams FM, Rawlins MD, James OFW (1984) The effect of aging on pathways of drug metabolism in human liver. Age Aging 13:328–344

    Article  CAS  Google Scholar 

  • Worner TM, Lieber CS (1985) Perivenular fibrosis as precursor lesion of cirrhosis. JAMA 254:627–630

    Article  CAS  Google Scholar 

  • Wu AW (2000) Adverse drug events and near misses: who’s counting? Am J Med 109(2):166–168

    Article  CAS  Google Scholar 

  • Wynne HA (2002) Age-related changes in liver, gall bladder and pancreas. Rev Clin Gerontol 12:12–20

    Google Scholar 

  • Wynne HA, Cope LH, Mutch E, Rawlins MD (1989a) The effect of age upon liver volume and apparent blood flow in health man. Hepatology 9:297–301

    Article  CAS  Google Scholar 

  • Wynne HA, Cope LH, James OFW, Rawlins MD, Woodhouse KW (1989b) The effect of age and frailty upon acetanilide clearance in man. Age Aging 18(6):415–418

    Article  CAS  Google Scholar 

  • Wynne HA, Dope LH, Mutch E, Rawlins MD, Woodhouse KW, James OFW (1989c) The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 9(2):297–301

    Google Scholar 

  • Xia X-L, Xi-Peng J, Pei-Lian L, Gu XQ, LaPorte RE, Tajima N (1995) Ascertainment corrected prevalence rate (ACPR) of leucopenia in workers exposed to benzene in small-scale industries calculated with capture-recapture methods. Biomed Environ Sci 8:30–34

    CAS  Google Scholar 

  • Yaar M, Gilchrest BA (2001) Skin aging. Postulated mechanisms and consequent changes in structure and function. Geriatr Dermatol 17(4):617–630

    CAS  Google Scholar 

  • Yamaguchi M, Ozaki K (1990) Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats. Res Exp Med 190:295–300

    Article  CAS  Google Scholar 

  • Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzales FJ, Korach KS, Maronpot RR, Negishi M (2006) Estrogen receptor α mediates 17α-ethynylestradiol causing hepatotoxicity. J Biol Chem 281(24):16625–16631

    Article  CAS  Google Scholar 

  • Yueh B, Shapiro N, MacLean CH, Shekelle PG (2003) Screening and management of adult hearing loss in primary care: scientific review. JAMA 289(15):11976–1985

    Article  Google Scholar 

  • Yoon P, Keylock KT, Hartman ME, Freund GG, Woods JA (2004) Macrophage hypo-responsiveness to interferon-G in aged mice is associated with impaired signaling through Jak-STAT. Mech Ageing Dev 125:137–143

    Article  CAS  Google Scholar 

  • Zeeh J, Platt D (2002) The aging liver: structural and functional changes and their consequences for drug treatment in old age. Gerontology 48(3):121–127

    Article  CAS  Google Scholar 

  • Zhan C, Sangl J, Bierman AS, Miller MR, Friedman B, Wickizer SW, Meyer GS (2001) Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA 286(22):2823–2829

    Article  CAS  Google Scholar 

  • Zharhary D (1988) Age-related changes in the capability of the bone marrow to generate B cells. J Immunol 141:1863–1869

    CAS  Google Scholar 

  • Zheng, W (2001) Neurotoxicology of the brain barrier system: new implications. Clin Toxicol 39(7):711–719

    Article  CAS  Google Scholar 

  • Zheng W, Blaner WS, Zhao Q (1999) Inhibition by Pb of production and secretion of transthyretin in the choroid plexus: its relationship to thyroxine transport at the blood–CSF barrier. Toxicol Appl Pharmacol 155:24–31

    Article  CAS  Google Scholar 

  • Zheng W, Shen H, Blaner SB, Zhao Q, Ren X, Graziano JH (1996) Chronic lead exposure alters transthyertin concentration in rat cerebrospinal fluid: the role of the choroid plexus. Toxicol Appl Pharmacol 139:445–450

    Article  CAS  Google Scholar 

  • Zimmerman HJ, Maddrey WC (1995) Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 22(3):767–773

    Article  CAS  Google Scholar 

  • Zouboulis CC, Boschnakow A (2001) Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol 26:600–607

    Article  CAS  Google Scholar 

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Risher, J.F., Todd, G.D., Meyer, D., Zunker, C.L. (2010). The Elderly as a Sensitive Population in Environmental Exposures: Making the Case. In: Whitacre, D. (eds) Reviews of Environmental Contamination and Toxicology Volume 207. Reviews of Environmental Contamination and Toxicology, vol 207. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6406-9_2

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