Protein Oxidation

Part of the Protein Reviews book series (PRON, volume 13)


Protein oxidation is a post-translational modification that can have beneficial or detrimental effects on cells. The interaction of reactive oxygen species (ROS) with proteins leads to their oxidation and ROS may be produced by several different enzymes. The first section of this review examines the major intracellular sources of ROS, with special attention paid to mitochondria and NADPH oxidases. It discusses the different oxidation of amino acid residues with a focus on cysteine oxidation as it is involved in many signaling pathways. Carbonylation and nitrosylation are two other protein modifications that are of particular importance in cellular metabolism. The final section is concerned with the role that protein oxidation plays in disease.


Reactive Oxygen Species Parkinson Disease Cystic Fibrosis Patient Protein Carbonyl Protein Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Alzheimer’s disease


Cystic fibrosis




Dual oxidase


Hydroxyl radical


Hydrogen peroxide






Nitric oxide


Nitric oxide synthase


NADPH Oxidase




Parkinson’s disease


Reactive nitrogen species


Reactive oxygen species


Superoxide dismutase




Xanthine dehydrogenase


Xanthine oxidase


Xanthine oxidoreductase



This work was supported by Science Foundation Ireland, Children Leukemia Research Project and the Irish Cancer Society.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • C. Quiney
  • S. Finnegan
  • G. Groeger
  • T. G. Cotter
    • 1
  1. 1.Cell Development and Disease Laboratory, Biochemistry Department, Biosciences InstituteUniversity CollegeCorkIreland

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