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Chromatin: The Entry to and Exit from DNA Repair

  • Anastas Gospodinov
  • Zdenko Herceg
Chapter
Part of the Protein Reviews book series (PRON, volume 13)

Abstract

All processes of DNA metabolism require a high degree of coordination with the processes that modify chromatin structure. Recent experimental efforts have established that post-translational modifications of histones and chromatin remodeling activities are required for DNA repair. Dynamic changes of chromatin are the means to control accessibility, coordinate binding of repair and signaling proteins and link DNA repair with the cell cycle. In this review, we focus on current understanding of the roles of histone modifications and chromatin remodeling events in repair of different DNA lesions.

Keywords

Histone Modification Chromatin Remodel Histone Acetylation Nucleotide Excision Repair Base Excision Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank to Drs Anupam Paliwal, Stoyno Stoynov, and Boyka Anachkova for critical reading of the manuscript. A.G. is supported by a Special Training Fellowship from the International Agency for Research on Cancer (IARC), Lyon, France. Work in our laboratory is supported by the International Agency for Research on Cancer (IARC), Lyon (France), and grants from National Institute of Health/National Cancer Institute, USA, the Association pour la Recherche sur le Cancer (ARC), France, la Ligue Nationale (Française) contre le Cancer (France), Institut National du Cancer, (France), Swiss Bridge Award, and Agence Nationale de Recherhe Contre le Sida et Hépatites Virales (ANRS, France) (to Z.H.).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Epigenetics GroupInternational Agency for Research on Cancer (IARC)LyonFrance

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