Chromatin: The Entry to and Exit from DNA Repair
All processes of DNA metabolism require a high degree of coordination with the processes that modify chromatin structure. Recent experimental efforts have established that post-translational modifications of histones and chromatin remodeling activities are required for DNA repair. Dynamic changes of chromatin are the means to control accessibility, coordinate binding of repair and signaling proteins and link DNA repair with the cell cycle. In this review, we focus on current understanding of the roles of histone modifications and chromatin remodeling events in repair of different DNA lesions.
KeywordsHistone Modification Chromatin Remodel Histone Acetylation Nucleotide Excision Repair Base Excision Repair
We thank to Drs Anupam Paliwal, Stoyno Stoynov, and Boyka Anachkova for critical reading of the manuscript. A.G. is supported by a Special Training Fellowship from the International Agency for Research on Cancer (IARC), Lyon, France. Work in our laboratory is supported by the International Agency for Research on Cancer (IARC), Lyon (France), and grants from National Institute of Health/National Cancer Institute, USA, the Association pour la Recherche sur le Cancer (ARC), France, la Ligue Nationale (Française) contre le Cancer (France), Institut National du Cancer, (France), Swiss Bridge Award, and Agence Nationale de Recherhe Contre le Sida et Hépatites Virales (ANRS, France) (to Z.H.).
- Bostelman, L.J., Keller, A.M., Albrecht A.M., et al. (2007). Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae. DNA Repair (Amst) 6:383–395.Google Scholar
- Burma, S., and Chen, D.J. (2004). Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) 3:909–918.Google Scholar
- Escargueil, A.E., Soares, D.G, Salvador, M., et al. (2008). What histone code for DNA repair? Mutat. Res. 658:259–270.Google Scholar
- Fortini, P., and Dogliotti, E. (2007). Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways. DNA Repair (Amst) 6:398–409.Google Scholar
- Stucki, M., and Jackson, S.P. (2006). gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 5:534–543.Google Scholar
- Toh, G.W., O’Shaughnessy, A.M., Jimeno, S.J., et al. (2006). Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair (Amst) 5:693–703.Google Scholar