Neuroimaging of Fatigue

  • Helen M. Genova
  • Glenn R. Wylie
  • John DeLuca


Fatigue is a common and debilitating symptom experienced in both clinical and healthy populations. In particular, individuals with Multiple Sclerosis (MS) and Chronic Fatigue Syndrome (CFS) frequently report high levels of fatigue which negatively affects their quality of life, including their ability to maintain a career. Even though fatigue is rated the most debilitating symptom of multiple clinical disorders and has therefore been the subject of scientific inquiry, scientists have been unsuccessful at finding an objective measure of fatigue using behavioral measures, and have had to rely on “self-reported fatigue.” This chapter focuses on the utilization of neuroimaging techniques to investigate fatigue in clinical samples (including CFS, MS, Traumatic Brain Injury, and Parkinson’s Disease) and how these techniques could potentially be used to uncover a more objective measure of fatigue.


Multiple Sclerosis Diffusion Tensor Imaging Chronic Fatigue Syndrome Functional Imaging Study Multiple Sclerosis Group 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Kessler Foundation Research CenterWest OrangeUSAand
  2. 2.Department of Physical Medicine and RehabilitationUniversity of Medicine and Dentistry of New Jersey – New Jersey Medical SchoolNewarkUSA

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