Skip to main content

Brain Imaging in Behavioral Medicine and Clinical Neuroscience: An Introduction

  • Chapter
  • First Online:
Brain Imaging in Behavioral Medicine and Clinical Neuroscience

Abstract

We are living in a remarkable time in the history of neuroscience. A little over a century ago, neuropsychology had not yet emerged as a formal area of scientific inquiry, and knowledge regarding brain function was largely limited to pioneering studies of the effects of brain damage on cognitive functions. Demonstration by Broca and Wernicke of expressive and receptive aphasia associated with focal brain lesions resulted in an initial understanding of the functional neuroanatomy of language (Broca, Rev Prat 49(16):1725–1727, 1999; Geschwind, Wernicke’s Contribution to the Study of Aphasia, 1997), while observation of effects of frontal lobe damage in the famous case of Phineus Gage spurred initial speculation about the role of the frontal lobes in behavior and emotional control (Harlow, J Neuropsychiatry Clin Neurosci 11(2):281–283, 1999). This led to a steady increase in scientific research in the clinic and laboratory over the first half of the twentieth century to understand brain function, providing a foundation of knowledge for the field of Neuropsychology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Broca PM. The discovery of cerebral localization. Rev Prat. 1999;49(16):1725–1727.

    PubMed  Google Scholar 

  2. Geschwind N. Wernicke’s Contribution to the Study of Aphasia. New York: Butterworth-Heinemann; 1997.

    Google Scholar 

  3. Harlow JM. Passage of an iron rod through the head. J Neuropsychiatry Clin Neurosci. 1999;11(2):281–283.

    PubMed  Google Scholar 

  4. Milner B. The medial temporal-lobe amnesic syndrome. Psychiatr Clin North Am. 2005;28(3):599–611. 609.

    Article  PubMed  Google Scholar 

  5. Heilman KM, Valenstein E. Mechanisms underlying hemispatial neglect. Ann Neurol. 1979;5(2):166–170.

    Article  PubMed  Google Scholar 

  6. Bradshaw FL. Pupil size and problem solving. Q J Exp Psychol. 1968;20:116–122.

    Article  PubMed  Google Scholar 

  7. Cohen RA, Waters W. Psychophysiological correlates of levels and states of cognitive processing. Neuropsychologia. 1985;23(2):243–256.

    Article  PubMed  Google Scholar 

  8. Jennings J, Hall SW. Recall, recognition, and rate: memory and the heart. Psychophysiology. 1980;17:37–46.

    Article  PubMed  Google Scholar 

  9. Wilkinson RT, Seales DM. EEG event-related potentials and signal detection. Biol Psychol. 1978;7(1–2):13–28.

    Article  PubMed  Google Scholar 

  10. Ciganek L. A comparative study of visual and auditory EEG responses in man. Electroencephalogr Clin Neurophysiol. 1965;18:625–629.

    Article  PubMed  Google Scholar 

  11. Mirsky AF, Tecce JJ. The analysis of visual evoked potentials during spike and wave EEG activity. Epilepsia. 1968;9(3):211–220.

    Article  PubMed  Google Scholar 

  12. Humphrey NK. Responses to visual stimuli of units in the superior colliculus of rats and monkeys. Exp Neurol. 1968;20(3):312–340.

    Article  PubMed  Google Scholar 

  13. Penfield W, Perot P. The brain’s record of auditory and visual experience. A final summary and discussion. Brain. 1963;86:595–696.

    Article  PubMed  Google Scholar 

  14. Mishkin M, Ungerleider LG. Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res. 1982;6(1):57–77.

    Article  PubMed  Google Scholar 

  15. Jagadeesh B, Chelazzi L, Mishkin M, Desimone R. Learning increases stimulus salience in anterior inferior temporal cortex of the macaque. J Neurophysiol. 2001;86(1):290–303.

    PubMed  Google Scholar 

  16. Morrell F, Engel JP Jr, Bouris W. The effect of experience on the firing pattern of visual cortical neurons. Electroencephalogr Clin Neurophysiol. 1967;23(1):89.

    PubMed  Google Scholar 

  17. Picton TW. The P300 wave of the human event-related potential. J Clin Neurophysiol. 1992;9(4):456–479.

    Article  PubMed  Google Scholar 

  18. Hillyard SA, Hink RF, Schwent VL, Picton TW. Electrical signs of selective attention in the human brain. Science. 1973;182(108):177–180.

    Article  PubMed  Google Scholar 

  19. McEvoy LK, Pellouchoud E, Smith ME, Gevins A. Neurophysiological signals of working memory in normal aging. Brain Res Cogn Brain Res. 2001;11(3):363–376.

    Article  PubMed  Google Scholar 

  20. Squires KC, Squires NK, Hillyard SA. Decision-related cortical potentials during an auditory signal detection task with cued observation intervals. J Exp Psychol Hum Percept Perform. 1975;1(3):268–279.

    Article  PubMed  Google Scholar 

  21. Desolneux A, Lionel Moisan L, Morel JM. The Helmholtz Principle from Gestalt Theory to Image Analysis: A Probabilistic Approach. New York: Springer; 2008:31–45.

    Google Scholar 

  22. Hjorth B, Rodin E. Extraction of “deep” components from scalp EEG. Brain Topogr. 1988;1(1):65–69.

    Article  PubMed  Google Scholar 

  23. O’Donnell BF, Cohen RA, Hokama H, et al. Electrical source analysis of auditory ERPs in medial temporal lobe amnestic syndrome. Electroencephalogr Clin Neurophysiol. 1993;87(6):394–402.

    Article  PubMed  Google Scholar 

  24. Halgren E, Raij T, Marinkovic K, Jousmaki V, Hari R. Cognitive response profile of the human fusiform face area as determined by MEG. Cereb Cortex. 2000;10(1):69–81.

    Article  PubMed  Google Scholar 

  25. Vieth J. Magnetoencephalography, a new function diagnostic method. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984;15(2):111–118.

    PubMed  Google Scholar 

  26. Roy C, Sherrington CS. On the regulation of the blood-supply of the brain. Physiology. 1890;11(1–2):85–108.

    Google Scholar 

  27. Findlay GF. Computer-assisted (axial) tomography in the management of subarachnoid haemorrhage. Surg Neurol. 1980;13(2):125–128.

    PubMed  Google Scholar 

  28. Dunker K. On Problem Solving. Washington, DC: American Psychological Association; 1945.

    Google Scholar 

  29. Ackerman RH, Subramanyam R, Correia JA, Alpert NM, Taveras JM. Positron imaging of cerebral blood flow ­during continuous inhalation of C15O2. Stroke. 1980;11(1):45–49.

    PubMed  Google Scholar 

  30. Yamamoto YL, Thompson CJ, Meyer E, Robertson JS, Feindel W. Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr. J Comput Assist Tomogr. 1977;1(1):43–56.

    Article  PubMed  Google Scholar 

  31. Hill TC. Single-photon emission computed tomography to study cerebral function in man. J Nucl Med. 1980;21(12):1197–1199.

    PubMed  Google Scholar 

  32. Jezzard P, Matthews PM, Smith SM, eds. Functional MRI: An Introduction to Methods. New York, NY: Oxford University Press; 2001.

    Google Scholar 

  33. Pauling L, Coryell CD. The magnetic properties and structure of the hemochromogens and related substances. Proc Natl Acad Sci U S A. 1936;22:159–163.

    Article  PubMed  Google Scholar 

  34. Kwong KK, McKinstry RC, Chien D, Crawley AP, Pearlman JD, Rosen BR. CSF-suppressed quantitative single-shot diffusion imaging. Magn Reson Med. 1991;21(1):157–163.

    Article  PubMed  Google Scholar 

  35. Rosen BR, Belliveau JW, Buchbinder BR, et al. Contrast agents and cerebral hemodynamics. Magn Reson Med. 1991;19(2):285–292.

    Article  PubMed  Google Scholar 

  36. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A. 1990;87(24):9868–9872.

    Article  PubMed  Google Scholar 

  37. Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med. 1990;14(1):68–78.

    Article  PubMed  Google Scholar 

  38. Crosson B, Rao SM, Woodley SJ, et al. Mapping of semantic, phonological, and orthographic verbal working memory in normal adults with functional magnetic resonance imaging. Neuropsychology. 1999;13(2):171–187.

    Article  PubMed  Google Scholar 

  39. Rao SM, Harrington DL, Haaland KY, Bobholz JA, Cox RW, Binder JR. Distributed neural systems underlying the timing of movements. J Neurosci. 1997;17(14):5528–5535.

    PubMed  Google Scholar 

  40. Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional magnetic resonance imaging. J Neurosci. 1997;17(1):353–362.

    PubMed  Google Scholar 

  41. Gsell W, Burke M, Wiedermann D, et al. Differential effects of NMDA and AMPA glutamate receptors on functional magnetic resonance imaging signals and evoked neuronal activity during forepaw stimulation of the rat. J Neurosci. 2006;26(33):8409–8416.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ronald A. Cohen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Cohen, R.A., Sweet, L.H. (2011). Brain Imaging in Behavioral Medicine and Clinical Neuroscience: An Introduction. In: Cohen, R., Sweet, L. (eds) Brain Imaging in Behavioral Medicine and Clinical Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6373-4_1

Download citation

Publish with us

Policies and ethics