Blood Flow and Arterial Disease

  • Nicolaas Westerhof
  • Nikolaos Stergiopulos
  • Mark I. M. Noble


Hemodynamic forces not only regulate blood vessel geometry and structure, i.e., remodeling, but they can be considered also as main factors influencing the development of different forms of vascular disease, such as atherosclerosis, and aneurysms. Of particular importance is the role of shear stress, the minute force resulting from the friction that the flowing blood exerts on the luminal surface, on the localization and development of atherosclerosis.


Shear Stress Wall Shear Stress Balloon Angioplasty Vein Graft Intima Hyperplasia 
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Copyright information

© Springer US 2010

Authors and Affiliations

  • Nicolaas Westerhof
    • 1
  • Nikolaos Stergiopulos
    • 2
  • Mark I. M. Noble
    • 3
  1. 1.Departments of Physiology and Pulmonology ICaR-VUVU University Medical CenterAmsterdamthe Netherlands
  2. 2.Laboratory of Hemodynamics and Cardiovascular TechnologySwiss Federal Institute of TechnologyLausanneSwitzerland
  3. 3.Cardiovascular MedicineAberdeen UniversityAberdeenScotland

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